The coronavirus outbreak caused significant changes in football around the world, such as the suspension of leagues and home isolation of players, etc. The main purpose of the present study was to assess the psychological impacts of lockdown and similar restrictions on professional football players during the coronavirus pandemic. The players from 36 professional football teams (n=977) among Turkish Super League and First League teams were invited to complete a questionnaire including the Center for Epidemiologic Studies Depression Scale (CES-D), Impact of Event Scale-Revised Scores (IES-R) and short form of International Physical Activity Questionnaire (IPAQ). The online survey was completed by 237 players (24.3%). The mean number of self-quarantine day of participants was 26.9±6.2days. The median CES-D Scale and IES-R scores were 6.0 (min0, max42) and 23.0 (min0, max59), respectively. IPAQ scores of the players showed that four-fifths of the players still maintain high physical activity levels. There were negative, very weak and significant correlations between CES-D score and being married (r=-0.146, p =0.024), as well as between CES-D score and IPAQ-Walking (r=-0.189, p =0.004). A significant positive very weak correlation was observed between CES-D score and self-quarantine days (r=0.148, p =0.024). IPAQ-Walking was an independent predictor of CES-D. These findings support that maintaining regular physical activity and routinely exercising in a safe home environment is one of the most important strategies to ensure healthy mental state.These findings support that maintaining regular physical activity and routinely exercising in a safe home environment is one of the most important strategies to ensure healthy mental state. Acute myeloid leukemia (AML) is an aggressive blood cancer that proves fatal for the majority of affected individuals. Older patients are particularly vulnerable due to more unfavorable disease biology and diminished ability to tolerate intensive induction chemotherapy (ICT). Safer, more efficacious therapies are desperately needed. We briefly summarize the challenges facing AML treatment and introduce the rapidly expanding therapeutic landscape. Our focus is on the Hedgehog (Hh) pathway and how preclinical evidence has spurred the clinical development of selective inhibitors for oncology indications. Glasdegib is the first Hh pathway inhibitor approved for the treatment of a hematologic malignancy, and we review its pharmacology, safety, efficacy, and potential clinical impact in AML patients. Advances in the mechanistic understanding of AML have started to translate into improved therapeutic options for patients with contraindications to ICT. Glasdegib improved overall survival in this population whening relapse, is needed to better define its clinical utility.Lack of culturally sensitive, age-specific diabetes education in Mexican American older aged people may contribute to deficits in diabetes knowledge, self-management, and glycemic control. This quality improvement initiative applied evidence-based, culturally competent, age-specific education to improve health outcomes. A one-group, pretest/posttest design guided this project in a primary care community clinic. Mexican American adults >60 years, with type 2 diabetes mellitus (T2DM; N = 12) received 3 months of biweekly innovative classes including healthy Mexican foods; family involvement; Spanish interpreter using simultaneous earphone technology; and interactive, bilingual, large-print materials. Paired sample t tests compared diabetes knowledge, self-management, and A1C levels. There was a significant improvement in preeducation and posteducation outcomes knowledge, t(11) = -7.969, p = .000; d = 2.32, self-management, t(11) = -7.930, p = .000; d = 2.43, and A1C levels, t(11) = 6.434, p = .000; d = 0.78. Culturally competent, language-friendly innovation, age-specific T2DM education can positively impact knowledge, self-management behaviors, and glycemic values in older aged Mexican American people.RNA editing is one of the most prevalent and abundant forms of post-transcriptional RNA modification observed in normal physiological processes and often aberrant in diseases including cancer. RNA editing changes the sequences of mRNAs, making them different from the source DNA sequence. Edited mRNAs can produce editing-recoded protein isoforms that are functionally different from the corresponding genome-encoded protein isoforms. The major type of RNA editing in mammals occurs by enzymatic deamination of adenosine to inosine (A-to-I) within double-stranded RNAs (dsRNAs) or hairpins in pre-mRNA transcripts. Enzymes that catalyse these processes belong to the adenosine deaminase acting on RNA (ADAR) family. The vast majority of knowledge on the RNA editing landscape relevant to human disease has been acquired using in vitro cancer cell culture models. The limitation of such in vitro models, however, is that the physiological or disease relevance of results obtained is not necessarily obvious. In this review we focus on discussing in vivo occurring RNA editing events that have been identified in human cancer tissue using samples surgically resected or clinically retrieved from patients. We discuss how RNA editing events occurring in tumours in vivo can identify pathological signalling mechanisms relevant to human cancer physiology which is linked to the different stages of cancer progression including initiation, promotion, survival, proliferation, immune escape and metastasis.The present study was conducted to identify the kinematic variables associated with dolphin kick performance during the acceleration and deceleration phases. Nine male competitive swimmers performed 3-5 × 15-m dolphin kick swimming trials with maximum effort. Ginkgolic cell line The underwater motion of the dolphin kick was recorded using a digital video camera for a two-dimensional motion analysis. Upper-lower trunk and leg angles in addition to shoulder, hip, and knee joint angles were calculated as kinematic variables. The average horizontal velocity of the greater trochanter during two cycles of the dolphin kick correlated with the angular displacement of the lower trunk in the acceleration (r = -0.715, p less then 0.05) and deceleration phases (r = 0.682, p less then 0.05). Furthermore, greater angular displacement of the lower trunk was associated with smaller angular displacement of the upper leg and greater angular displacement of the hip, knee, and lower leg in both phases. These results suggest that the movement of the lower trunk is a key kinematic variable for dolphin kick performance, and also that swimming coaches and swimmers need to focus on the movement of the lower trunk as well as upper-lower legs in order to improve dolphin kick motion.