The main variables were anthropometric indices including body weight, levels of leptin, IGF-1, glucagon, adiponectin, fasting blood glucose, and UCP-1. Results Following the search in mentioned databases, ten articles were entered into this systematic review. In most studies, weight gain and white adipocyte size were reduced in the BAT transplant group. It seems that the transplantation leads to the regeneration of healthy adipose tissue by activating the endogenous BAT. Conclusions Since BAT transplantation is one of the possible future treatments of obesity, many studies are conducted to evaluate the outcomes and related procedures precisely, so it can finally step into clinical application.In eukaryotes, trimethylation of lysine 9 on histone H3 (H3K9) is associated with transcriptional silencing of transposable elements (TEs). In drosophila ovaries, this heterochromatic repressive mark is thought to be deposited by SetDB1 on TE genomic loci after the initial recognition of nascent transcripts by PIWI-interacting RNAs (piRNAs) loaded on the Piwi protein. Here, we show that the nucleosome remodeler Mi-2, in complex with its partner MEP-1, forms a subunit that is transiently associated, in a MEP-1 C-terminus-dependent manner, with known Piwi interactors, including a recently reported SUMO ligase, Su(var)2-10. Together with the histone deacetylase Rpd3, this module is involved in the piRNA-dependent TE silencing, correlated with H3K9 deacetylation and trimethylation. Therefore, drosophila piRNA-mediated transcriptional silencing involves three epigenetic effectors, a remodeler, Mi-2, an eraser, Rpd3 and a writer, SetDB1, in addition to the Su(var)2-10 SUMO ligase.Nighttime light (NTL) data from the Defense Meteorological Satellite Program (DMSP)/Operational Linescan System (OLS) and the Visible Infrared Imaging Radiometer Suite (VIIRS) on the Suomi National Polar-orbiting Partnership satellite provide a great opportunity for monitoring human activities from regional to global scales. Despite the valuable records of nightscape from DMSP (1992-2013) and VIIRS (2012-2018), the potential of the historical archive of NTL observations has not been fully explored because of the severe inconsistency between DMSP and VIIRS. In this study, we generated an integrated and consistent NTL dataset at the global scale by harmonizing the inter-calibrated NTL observations from the DMSP data and the simulated DMSP-like NTL observations from the VIIRS data. The generated global DMSP NTL time-series data (1992-2018) show consistent temporal trends. This temporally extended DMSP NTL dataset provides valuable support for various studies related to human activities such as electricity consumption and urban extent dynamics.The western North Pacific Subtropical High (WNPSH) is a key circulation system controlling the summer monsoon and typhoon activities over the western Pacific, but future projections of its changes remain hugely uncertain. Here we find two leading modes that account for nearly 80% intermodel spread in its future projection under a high emission scenario. They are linked to a cold-tongue-like bias in the central-eastern tropical Pacific and a warm bias beneath the marine stratocumulus, respectively. Observational constraints using sea surface temperature patterns reduce the uncertainties by 45% and indicate a robust intensification of the WNPSH due to suppressed warming in the western Pacific and enhanced land-sea thermal contrast, leading to 28% more rainfall projected in East China and 36% less rainfall in Southeast Asia than suggested by the multi-model mean. The intensification of the WNPSH implies more future monsoon rainfall and heatwaves but less typhoon landfalls over East Asia.The mechanistic action of histone deacetylase 8 (HDAC8) in cancer motility, including epithelial-mesenchymal transition (EMT), remains largely undefined. We found that the expression of HDAC8 was upregulated in breast cancer (BC) cells and tissues as compared to the controls. Further, BC tissues had the highest values of HDAC8 expression among 31 kinds of cancers. Cellular study indicated that HDAC8 can positively regulate the dissemination and EMT of BC cells. It increased the protein stability of Snail, an important regulator of EMT, by phosphorylation of its motif 2 in serine-rich regions. L-Adrenaline in vivo There are 21 factors that have been reported to regulate the protein stability of Snail. Among them, HDAC8 can decrease the expression of GSK-3β through increasing its Ser9-phosphorylation. Mass spectrum analysis indicated that HDAC8 interact with AKT1 to decrease its acetylation while increase its phosphorylation, which further increased Ser9-phosphorylation of GSK-3β. The C-terminal of AKT1 was responsible for the interaction between HDAC8 and AKT1. Further, Lys426 was the key residue for HDAC8-regulated deacetylation of AKT1. Moreover, HDAC8/Snail axis acted as adverse prognosis factors for in vivo progression and overall survival (OS) rate of BC patients. Collectively, we found that HDAC8 can trigger the dissemination of BC cells via AKT/GSK-3β/Snail signals, which imposed that inhibition of HDAC8 is a potential approach for BC treatment.Aim The purpose of this study was to investigate the association of dietary patterns with the risk of insulin resistance (IR), diabetes mellitus (DM), and central obesity in China. Methods We performed a cross-sectional study on 1432 participants, aged 40-65 years in Hangzhou, Zhejiang province, China. Dietary intake was assessed using a semi-quantitative food frequency questionnaire. Results Factor analysis extracted four major dietary patterns vegetable-fruits, rice-meat, seafood-eggs, and sweet-fast. The vegetable-fruits pattern was inversely associated with HOMA-IR (p less then 0.001 in both genders), while sweet-fast food pattern was significantly associated with higher HOMA-IR (p = 0.002 in male, and p less then 0.001 in female). The vegetables-fruits pattern was inversely correlated with visceral fat area (VFA) (p = 0.029 in males, and p = 0.017 in females), while sweet-fast food pattern presented a significant direct association (p less then 0.001 in male) with VFA in males. There was no association observed between the rice-meat pattern or the seafood-eggs pattern and HOMA-IR or VFA.