Most perturbed metabolic pathways from co-exposure heavy metals and phthalates were pathways related to the tricarboxylic acid cycle (TCA cycle) and oxidative phosphorylation, indicating the possibility of disruption of mitochondrial respiration. Overproduction of reactive oxygen species (ROS); the presence of glutathione peroxidase 3 (GPx3) during pregnancy and presence of glutathione peroxidase 1 (GPx1) in the umbilical cord were linked to verbal development problems. Another finding of the study is that in real life, adverse outcomes occur as a combination of environmental and social factors, all of them acting synergistically towards the deployment of an observed phenotype. Finally, the two-steps association process (exposure to pathways and pathways to adverse outcomes) was able to (a) provide associations that are not evident by directly associating exposure to outcomes and (b) provides additional insides on the mechanisms of environmental disease.Monochloramine (MCA) is often used as a secondary disinfectant in drinking water distribution systems (DWDS) for controlling the regrowth of microorganisms. Laboratory experiments to study the efficacy of MCA and formation of disinfection byproducts in DWDS all require the preparation of MCA. Different protocols for the preparation of MCA have been used in the literature. In this study, we compared four published protocols that are frequently used to prepare MCA in the environmental research community. Our results showed that the choice of protocol could result in substantial differences in decay kinetics and disinfection efficacy of the prepared MCA. selleck kinase inhibitor The discrepancies highlight an immediate need for the standardization of MCA preparation protocols for laboratory-scale drinking water research.Exposure to green space has been associated with a range of human health benefits, largely in spatial epidemiological studies. Green space and artificial light at night are both associated with breast and prostate cancer, depressive symptoms, obesity, and sleep problems, and are both influenced by the built environment and urbanisation. We identified a negative correlation between green space diversity and outdoor artificial light at night for Australian major cities. Outdoor artificial light at night is therefore a potential, but overlooked, confounder in spatial epidemiological studies of green space exposure and human health, and should be incorporated into future models.Existence of human beings in this world require a cleaner environment, in which, water is the main requirement for living. Owing to the considerable development in civilisation and considerable population explosion, an increase in the contamination of natural water resources by means of non-biodegradable contaminants like heavy metals is observed thereby increasing the need for treatment of water before usage. Despite the existence of specific limits for disposal of heavy metals in water resources, studies still show high contamination of heavy metals in all these water resources. This review provides a brief note on sources and toxicity of different heavy metals in various oxidation states, their effects as well as highlights the numerous available and advanced techniques for heavy metals removal. Of all techniques adsorption is found to be beneficial as it doesn't inculcate any secondary pollutants to the environment. Additionally, this article has investigated the advantages of polymer nanocomposites in adsorption and mainly focused on biopolymer chitosan owing to its abundance in natural environment. The cleaner techniques for the extraction of chitosan and its functionalisation using different types of nanofillers are comprehensively discussed in this review. This article suggests a better alternative for conventional adsorbents as well as aids in remediation of wastes.Congenital heart disease (CHD) is the most common congenital anomaly and one of the leading causes of newborn death. Few studies analyze multiple ambient air pollutants and different congenital heart disease subtypes at the same time. We conducted a meta-analysis to explore the association between gestational air pollution exposure and CHD subtypes. We searched PubMed, Embase, Web of Science from inception till July 31, 2020. Newcastle Ottawa Scale (NOS) was used to evaluate the quality of the literature. Funnel plots and Egger's regression were used to estimate publication bias. Heterogeneity was evaluated by the chi-square test and the coefficient of inconsistency I2 in this study. Finally, we performed a subgroup analysis to find reasons for heterogeneity. In the preliminary analysis, the result shows that the association between air pollutants and congenital heart disease was not statistically significant, except for CO and SO2. There is a positive association between air pollutants and ventricular septal defect (VSD) in our subtype analysis, the OR (95%CI) for PM10, PM2.5, and O3 was 1.057(1.005-1.109), 1.208(1.080-1.337), and 1.205(1.101-1.310), respectively. In addition, we also observed a negative association between SO2 and atrial septal defect (ASD) (OR 0.817, 95%CI 0.743-0.890) in subgroup analysis. The source of heterogeneity in our study mainly included study area and exposure time. These findings have implications for researchers to further study the relationship between air pollution and congenital heart disease. Evidence of immediate and delayed effects of climatic drivers on hospital admissions for schizophrenia is limited and inconsistent. We aimed to assess the association between climatic factors and daily hospital admissions for schizophrenia in Queensland, Australia. Daily hospital admissions for schizophrenia from January 1, 1996 to December 31, 2015 in all private and public hospitals of Queensland were obtained from Queensland Health. The association between climatic factors and hospital admissions for schizophrenia were analysed using Generalised Linear Models with Poisson distribution (GLM) and Distributed Lag non-linear Models (DLNM) across different climatic zones. In South East Queensland, only daily mean temperature showed an immediate negative effect on schizophrenia admissions (RR 0.93, 95%CI 0.90-0.98, p value<0.001). For other regions, the adverse effect of temperature on hospital admissions was not significant, however, relative humidity (North RR 1.01, 95%CI 1.00-1.02, p=0.05) and air pressure (North RR 1.