ogression and inflammation by targeting miR-204 through APOL1/NF-κB signaling.Collectively, these results illustrated that knockdown of lncRNA MALAT1 could ameliorate AKI progression and inflammation by targeting miR-204 through APOL1/NF-κB signaling. To examine the effectiveness of targeted nursing interventions on mobilization, nutrition and cognitive engagement to reduce functional and hospital-associated decline (HAD) in older patients. Systematic review of experimental studies using randomized and quasi-experimental designs. We searched electronic databases CINAHL, MEDLINE, EMBASE, Cochrane library, google scholar and BMJ quality reports from January 2009 to February 2020. We reviewed intervention studies that targeted ward nursing teams to increase mobilization, nutrition or cognitive engagement of older adults. Inclusion criteria included older patients, acute care (medical, surgical and older adult wards) and reporting patient level outcomes. Quality appraisal included the Joanna Briggs Critical Appraisal Checklist for Quasi-Experimental Studies. From 1729 papers, 18 studies using quasi-experimental and pre-post designs were selected. Sulfopin manufacturer Study heterogeneity necessitated a narrative synthesis. The quality of evidence was low to moderate. All dress ward and system barriers to prioritize fundamental care to improve patient outcomes. There is sufficient evidence on multicomponent interventions and implementation strategies to inform nurse-led quality improvement.Nursing teams with the support of hospital management have to address ward and system barriers to prioritize fundamental care to improve patient outcomes. There is sufficient evidence on multicomponent interventions and implementation strategies to inform nurse-led quality improvement.There is a considerable interest in the asymmetric production of chiral allylic alcohols, the main building blocks of many functional molecules. The asymmetric reduction of α,β-unsaturated ketones is difficult with traditional chemical protocols in a regioselective and stereoselective manner. In this study, the reductive capacity of whole cell of Leuconostoc mesenteroides N6, Weissella paramesenteroides N7, Weissella cibaria N9, and Leuconostoc pseudomesenteroides N13 was investigated as whole-cell biocatalysts in the enantioselective reduction of (E)-4-phenylbut-3-en-2-one (1). The biocatalytic reduction of 1 to (S,E)-4-phenylbut-3-en-2-ol ((S,E)-2) using the whole cell of W. cibaria N9 isolated from Turkish sourdough was developed in a regioselective fashion, occurring with excellent conversion and recovering the product in good yield. In biocatalytic reduction reactions, the conversion of the substrate and the enantiomeric excess (ee) of the product are significantly affected by optimization parameters such as temperature, agitation rate, pH, and incubation time. Effects of these parameters on ee and conversion were investigated comprehensively. In addition, to our knowledge, this is the first report on production of (S,E)-2 using whole-cell biocatalyst in excellent yield, conversion with enantiopure form and at gram scale. These findings pave the way for the use of whole cell of W. cibaria N9 for challenging higher substrate concentrations of different α,β-unsaturated ketones for regioselective reduction at industrial scale. To develop and evaluate a novel and generalizable super-resolution (SR) deep-learning framework for motion-compensated isotropic 3D coronary MR angiography (CMRA), which allows free-breathing acquisitions in less than a minute. Undersampled motion-corrected reconstructions have enabled free-breathing isotropic 3D CMRA in ~5-10 min acquisition times. In this work, we propose a deep-learning-based SR framework, combined with non-rigid respiratory motion compensation, to shorten the acquisition time to less than 1 min. A generative adversarial network (GAN) is proposed consisting of two cascaded Enhanced Deep Residual Network generator, a trainable discriminator, and a perceptual loss network. A 16-fold increase in spatial resolution is achieved by reconstructing a high-resolution (HR) isotropic CMRA (0.9 mm or 1.2 mm ) from a low-resolution (LR) anisotropic CMRA (0.9 × 3.6 × 3.6 mm or 1.2 × 4.8 × 4.8 mm ). The impact and generalization of the proposed SRGAN approach to different input resolutions and operation on image and patch-level is investigated. SRGAN was evaluated on a retrospective downsampled cohort of 50 patients and on 16 prospective patients that were scanned with LR-CMRA in ~50 s under free-breathing. Vessel sharpness and length of the coronary arteries from the SR-CMRA is compared against the HR-CMRA. SR-CMRA showed statistically significant (P < .001) improved vessel sharpness 34.1% ± 12.3% and length 41.5% ± 8.1% compared with LR-CMRA. Good generalization to input resolution and image/patch-level processing was found. SR-CMRA enabled recovery of coronary stenosis similar to HR-CMRA with comparable qualitative performance. The proposed SR-CMRA provides a 16-fold increase in spatial resolution with comparable image quality to HR-CMRA while reducing the predictable scan time to <1 min.The proposed SR-CMRA provides a 16-fold increase in spatial resolution with comparable image quality to HR-CMRA while reducing the predictable scan time to less then 1 min.Single-crystalline domains in intergrown microcrystalline material of the new compounds Ba22.5+x La55-x [Si129 N240-x Ox ]O3 Ce3+ and Ba25.5+x La77-x [Si170 N312-x O9+x ]O4 Ce3+ were identified by transmission electron microscopy (TEM). Precise diffraction data from these domains were collected with microfocused synchrotron radiation so that crystal structure elucidation of the complex disordered networks became possible. They are composed of two different interconnected slabs of which one is similar in both compounds, which explains their notorious intergrowth. The distribution of Ba and La is indicated by the analysis of bond-valence sums and by comparison with isostructural Sr28.5+x La75-x [Si170 N312-x O9+x ]O4 . Ce3+ doping leads to yellow luminescence. This is a showcase that highlights the discovery and accurate characterization of new compounds relevant for luminescence applications from heterogeneous microcrystalline samples by exploiting the capability of the combination of TEM and diffraction using the latest focusing techniques for synchrotron radiation.