Although costs were higher by $28 million, the incremental cost-effectiveness ratio was $86,458, below the willingness-to-pay threshold. CONCLUSIONS For children at intermediate risk of SCD and HCM, in-home AED is cost effective, resulting in fewer deaths and increased QALYS for a cost below the willingness-to-pay threshold. These findings highlight the economic benefits of in-home AED utilization in this population. In 2012, a novel canine Dirofilaria species, D. hongkongensis was identified in Hong Kong that caused human diseases and subsequently reported in an Austrian traveller returning from the Indian subcontinent. Here we present a case of human infection by D. hongkongensis manifested as recurrent shoulder mass. Diagnosis was achieved by cox1 gene sequencing of the excised specimen. The case illustrated that parasitic infection represents an important differential diagnosis for musculoskeletal lesions. OBJECTIVES Early onset sepsis (EOS) incidence has decreased since national guidelines and intrapartum prophylaxis were introduced. However, there has been a rising concern in antibiotic overtreatment for suspicion of EOS. A web-based EOS calculator has recently been used to evaluate the risk in newborns ≥ 34 weeks. Our purpose was to compare local strategies with the EOS calculator in our setting with an EOS incidence of 2/1000 live births. METHODS A retrospective review of all newborns born ≥ 34 weeks from January 1, 2016 to December 31, 2017 was completed after receiving IRB approval. We applied the calculator to those eligible using an EOS incidence of 0.6/1000 and 2/1000 live births and divided the patients into four cohorts. The rate of antibiotic use was compared between local evidence-based guidelines and the EOS calculator. RESULTS Of the 1367 newborns included in the study, 679 received antibiotics. Over the two years, antibiotic utilization decreased by 38%. The calculator would have recommended antibiotics for 468 patients (31% decrease) for an EOS incidence of 0.6/1000, but with a 2/1000 incidence rate the calculator recommended antibiotics for 673 patients (1% decrease). CONCLUSIONS The EOS calculator has been helpful in optimizing antibiotic use, but its use may result in suboptimal treatment without the knowledge of local EOS incidence. Our local antibiotic stewardship guidelines seemed to be comparable to the EOS calculator, especially by the last six months of the study period. PURPOSE The purpose of this study was to culturally adapt the Intensive Care Experience Questionnaire (ICEQ) for Korean patients, and evaluate its validity and reliability. METHODS This cross-sectional study comprised two phases. The first phase involved the cultural adaptation of the ICEQ. In the second phase, the psychometric properties of the adapted measure were evaluated. Cultural adaptation was conducted in accordance with the World Health Organization's process. The adapted questionnaire was administered to 200 Korean patients who had received treatment in an intensive care unit within the past six months. iCRT14 Model fit was assessed through confirmatoryfactor analysis, and convergent validity and discriminant validity of the items were assessed. Known-groups validity was evaluated using the t-test and Cohen's effectsize. Cronbach's alpha was used to examine internal consistency reliability. RESULTS The Korean version of the ICEQ (K-ICEQ) consists of 26 items and four subscales Frightening Experiences, Awareness of Surroundings, Satisfaction with Care, and Recall of Experiences. The model fit indices, convergent validity, and discriminant validity of the K-ICEQ were all satisfactory. According to the results of the test of known-groups validity, ICU experience varied according to gender, planned ICU admission, mechanical ventilation, restraints application. Cronbach's alphas of the KICEQ subscales ranged from .74 to .93. CONCLUSIONS The validity and reliability of the K-ICEQ reflecting the characteristics of Korean ICU patients were satisfactory. The K-ICEQ can be used to evaluate the experience of Korean ICU patients and contribute to the development of interventions to improve the ICU experience. V.PURPOSE Late radiation-induced contrast enhancing brain lesions (CEBL) on magnetic resonance (MR) images after proton therapy of brain tumors have been observed to occur frequently in regions of high linear energy transfer (LET) and in proximity to the ventricular system. We analyzed 110 low-grade glioma patients treated with proton therapy to determine if the risk for CEBLs is increased in proximity to the ventricular system and if there is a relationship between relative biological effectiveness (RBE) and LET. METHODS AND MATERIALS We contoured CEBLs identified on follow-up T1-MR images and computed dose and dose-averaged LET (LETd) distributions for all patients with Monte Carlo. We then performed cross-validated voxel-level logistic regression to predict local risks for image change and to extract model parameters, such as the RBE. From the voxel-level model, we derived a model for patient-level risk prediction based on the treatment plan. RESULTS Out of 110 patients, 23 exhibited one or several CEBLs on follow-up MR images. The voxel-level logistic model has an accuracy of AUC = 0.94, Brier score = 2.6x10-5. Model predictions are a threefold increased risk in the 4 mm region around the ventricular system and an LETd-dependent RBE of e.g. 1.22 for LETd = 2 keV/μm and 1.56 for LETd = 5 keV/μm. The patient-level risk model has an accuracy of AUC = 0.78, Brier score = 0.13. CONCLUSIONS Our findings present clinical evidence for an increased risk in ventricular proximity and for a proton RBE that increases significantly with increasing LET. We present a voxel-level model that predicts accurately the localization of late MRI contrast change and extrapolate a patient-level model that allows treatment-plan based risk prediction. PURPOSE Kilovoltage Intrafraction Monitoring (KIM) is a novel software platform implemented on standard radiation therapy systems enabling real-time image-guided radiation therapy (IGRT). In a multi-institutional prospective trial, we investigated whether real-time IGRT improved the accuracy of the dose prostate cancer patients received during radiation therapy. METHODS AND MATERIALS Forty-eight patients with prostate cancer were treated with KIM-guided Stereotactic Ablative Radiation Therapy (SABR) with 36.25 Gy in five fractions. During KIM-guided treatment the prostate motion was corrected for by either beam gating with couch shifts or multileaf collimator tracking. A dose reconstruction method was used to evaluate the dose delivered to the target and organs at risk with and without real-time IGRT. Primary outcome was the effect of real-time IGRT on dose distributions. Secondary outcomes included patient-reported outcomes and toxicity. RESULTS Motion correction occurred in ≥1 treatment for 88% of patients (42/48) and 51% of treatments (121/235).