The crucial functions of chemokine/receptors in numerous parasitic infections, including leishmaniasis, are well documented. This study aimed to assess the serum levels of CC ligand (CCL) 2, CCL5, and CCL11 in cutaneous leishmaniasis (CL) patients. 64 patients, suffering from CL and 100 healthy people were selected, and their blood serum concentrations of CCL2, CCL5, and CCL11 were measured using enzyme-linked immunosorbent assay. The results demonstrated that while the mean serum levels of CCL5 and CCL11 increased significantly in CL patients, the mean serum levels of CCL2 decreased, compared to the control group. Despite the sufficient production of CCL5 and CCL11 in CL patients, they suffered from CCL2 deficiency, as the defense mechanism against parasitic infection. These findings suggest a mechanism that might partially explain the patients' susceptibility to persistent infection and their inability to clear the parasites.The use of Long Lasting Insecticidal Nets (LLINs) has greatly reduced the health and economic impact posed by malaria. This study evaluated the residual effect of LLINs on malaria parasite infections among non-LLIN users sleeping in rooms where nets were hung. This study was carried out at Federal University of Agriculture Abeokuta, Ogun State, Nigeria. A total of 259 students were systematically recruited into this study and were classified into two groups of LLINs users and non-users. The LLIN users were further classified according to the proportion of net usage and this includes;  50% respectively. Finger prick blood samples were collected from the participants and microscopically analysed for the presence of parasites. Demographic characteristics were also recorded. A general prevalence of 40.5% positivity for malaria was recorded among the study population. A significantly high prevalence (p  less then  0.05) of malaria was recorded among non-users of LLINs compared to users (AOR 4.66, 95%CI 1.27-17.06). A significantly low prevalence of malaria parasite infection was recorded among non-users of LLINs occupying rooms where LLINs was hung compared with non-users from rooms where LLIN were not used. selleck kinase inhibitor Furthermore, a reduction in prevalence of malaria and parasite densities was observed among non-users of LLINs (occupying rooms where LLINs was hung) as the proportion of LLIN usage increased in such rooms (p  less then  0.05). This study showed that some level of protection may be conferred on non-users of LLINs staying in rooms where LLINs are hung.Diminazene diaceturate (DIM) and isometamidium chloride hydrochloride (ISMM) have been widely used for the treatment of animal trypanosomosis. We evaluated the efficacy of standard doses of DIM and ISMM followed by their double doses for the treatment of Trypanosoma evansi in experimentally infected mice. A T. evansi strain obtained from a naturally infected camel in Afar was used. 25 swiss white mice randomly divided in to five groups were inoculated with 0.2 mL of blood containing 103 trypanosomes. At the peak of parasitemia (≈ 2 weeks post infection), groups A and B were treated with the standard dose (3.5 mg/kg body weight [BWT]) of DIM; groups C and D were treated with the standard dose (0.5 mg/kg BWT) of ISMM; and group E served as infected control. In the DIM standard dose groups, relapses and peak parasitemia were observed 20- and 25-days post treatment respectively. Similarly, relapses and peak parasitemia were observed 21- and 27-days post treatment in the ISMM standard dose groups. All mice in the control group died within two weeks post infection. Following relapses, mice were treated with the double doses of DIM (7 mg/kg BWT) or ISMM (1 mg/kg BWT). Parasitemia was not detected for 3 months following the double dose treatments. Following dexamethasone administration for 7 days, all but one mouse in the DIM group remained negative for another month. In general, although the T. evansi strain was resistant to the standard doses of DIM and ISMM their double doses completely cleared the infection.Infection with Moniliformis moniliformis is rare in Iraq since it has been recorded only twice by Ministry of Health. In the current study, the morphology of the parasite is evaluated to explain the basic structure of the parasite parasitizing a human body in Iraq, including the adult worm and the egg stage which is considered the diagnostic stage for the detection of the intestinal parasite in the stool sample. The assessment of the adult worm showed that it was white in color and had a pseudo-segmented shape, lacked the digestive system or alimentary canal, and was 133 mm in length. The anterior end bore the cylindrical-shaped proboscis armed with 13 rows of hooks, each with 7-8 hooks and measured 0.42 × 0.21 mm. The egg was oval-shaped, covered with three envelops, contained hooks, and was 0.083 to 0.116 mm in length. The current study was performed on a single specimen that was revealed to be female during the examination.Malaria is a global health problem with severe morbidity and mortality in Sub-Saharan Africa. Resistance of Plasmodium spp to the current anti-malaria drugs necessitates further search for novel effective drugs. This study, therefore, investigated the effect of sodium acetate on glucose-6-phosphate dehydrogenase in Plasmodium berghei-infected mice. Thirty male Albino mice were randomly distributed into 6 groups, A-F. Animals in Groups B-F were inoculated with P. berghei, intraperitoneally. Subsequently, Group C mice were treated with 20 mg/kg chloroquine, while groups D, E and F received 25, 50 and 100 mg/kg sodium acetate, respectively. All treatments were administered orally for 4 days. At the end of the experiment, animals were sacrificed by cervical dislocation and blood was collected via cardiac puncture for the analyses of serum glucose-6-phosphate dehydrogenase (G6PD), uric acid and lipid profile. Our results showed that Sodium acetate (50 and 100 mg/kg) significantly reduced (p  0.05) but atherogenic lipid ratios were not affected by sodium acetate. These data put together suggested that activity of sodium acetate may be harnessed for development of novel anti-malaria drugs. However, more studies are required to delineate its mechanisms of action.