In general, the outcome of the studied patients receiving HCQ was good (no deaths, no intubation needed). CYP2D6 variants could affect the outcome of Covid-19 infection.In general, the outcome of the studied patients receiving HCQ was good (no deaths, no intubation needed). CYP2D6 variants could affect the outcome of Covid-19 infection.Metal base nanoparticles are widely produced all over the world and used in many fields and products such as medicine, electronics, cosmetics, paints, ceramics, toys, kitchen utensils and toothpastes. They are able to enter the body through digestive, respiratory, and alimentary systems. These nanoparticles can also cross the blood brain barrier, enter the brain and aggregate in the hippocampus. After entering the hippocampus, they induce oxidative stress, neuro-inflammation, mitochondrial dysfunction, and gene expression alteration in hippocampal cells, which finally lead to neuronal apoptosis. Metal base nanoparticles can also affect hippocampal neurogenesis and synaptic plasticity that both of them play crucial role in memory and learning. On the one hand, hippocampal cells are severely vulnerable due to their high metabolic activity, and on the other hand, metal base nanoparticles have high potential to damage hippocampus through variety of mechanisms and affect its functions. This review discusses, in detail, nanoparticles' detrimental effects on the hippocampus in cellular, molecular and functional levels to reveal that according to the present information, which types of nanoparticles have more potential to induce hippocampal toxicity and psychiatric disorders and which types should be more evaluated in the future studies.Despite the increasing awareness about its severity and the importance of adopting preventive habits, cardiovascular disease remains the leading cause of death worldwide. Most people already recognize that a healthy lifestyle, which includes a balanced diet and the practice of physical activity, is essential to prevent this disease. However, since few simple mechanisms allow a self-assessment and a continuous monitoring of the level of cardiac well-being, people are not conscious enough about their own cardiovascular health status. In this context, this paper presents and describes a tool related to the creation of cardiac well-being indexes that allow a quick and intuitive monitoring and visualization of the users' cardiovascular health level over time. For its implementation, data mining techniques were used to calculate the indexes, and a data warehouse was built to archive the data and to support the construction of dashboards for presenting the results. This study investigates protection against oxidative stress and memory enhancing potential of long-term consumption of leaves. Male Wistar rat were fed with mixture of -supplemented diets (MOSD) partitioned in 1, 5, 10, and 20% continuously for 12weeks. Object recognition test (ORT) and Morris water maze (MWM) was used for assessing neurocognition. Changes in body weight, Lipid peroxidation (MDA), Glutathione (GSH), Catalase (CAT) and Acetylcholinesterase (AChE) activity was assayed in the brain tissue. Histomorphometric of the hippocampus was also examined. The diets progressively increase the body weigh after the 12weeks, improved spatial (MWM) and non-spatial (ORT) memory performance, protect against oxidative stress, inhibit AChE activity and suppresses neuronal degeneration in the hippocampus when stained with Cresyl violent stain. Conclusively, long-term consumption of MOSD shows strong protection against oxidative stress and hippocampal degeneration and improves neurocognition with dose dependent effect.Conclusively, long-term consumption of MOSD shows strong protection against oxidative stress and hippocampal degeneration and improves neurocognition with dose dependent effect. The threat to human health or the surroundings by the use of artificial fruit ripening agents has become a global concern. Calcium carbide (CaC ) and ethylene glycol (EG) are the two widely using ripening agents. The present study evaluates the toxic effect of chronic exposures of CaC and EG in rats. CaC and EG were administered to the rats for 180days orally. The alterations in oxido-reduction status, haematological, biochemical and histopathological parameters were analysed. Arsenic content in CaC and animal samples were detected by atomic absorption spectrometer and phosphorus by molybdate-UV method. At chronic doses, there were no significant alterations in haematological and biochemical parameters except in creatinine level especially by EG. However, histological details revealed microvesicular fatty change in liver, corpuscles degeneration in kidney and lymphocytes infiltration in various tissues. In intestine, the mucosal lesion scoring was found high (p<0.01). SOD and CAT activities and GSH level was reduced significantly by CaC administration (p<0.01). Arsenic and phosphorus detected is above the toxic level 7.222 and 13.91mg/dL in CaC , 1.634 and 6.22mg/dL in blood and 0.563 and 6.99mg/dL in liver, respectively. The study suggests that the industrial grade CaC and EG induce systemic toxicity to rats and the liver is the most susceptible organ. The CaC and EG toxicity is mediated through the upset of redox balance and subsequent inflammatory responses. find more This could be due to the presence of arsenic and phosphorus contents that detected above the normal level in the industrial grade CaC .The study suggests that the industrial grade CaC2 and EG induce systemic toxicity to rats and the liver is the most susceptible organ. The CaC2 and EG toxicity is mediated through the upset of redox balance and subsequent inflammatory responses. This could be due to the presence of arsenic and phosphorus contents that detected above the normal level in the industrial grade CaC2. The novel coronavirus 2019 (COVID-19) pandemic has impacted the delivery of health care services throughout the United States, including those for patients with chronic pain. To measure changes in patients' utilization of nonpharmacological and pharmacological treatments for chronic low back pain and related outcomes during the COVID-19 pandemic. A pre-post study was conducted within the Pain Registry for Epidemiological, Clinical, and Interventional Studies and Innovation (PRECISION Pain Research Registry) using data in the 3 months before and 3-6months after the declaration of a national emergency related to COVID-19. Participants 21-79 years old with chronic low back pain were included in the study and provided self reported data at relevant quarterly encounters. Use of exercise therapy, yoga, massage therapy, spinal manipulation, acupuncture, cognitive behavioral therapy, nonsteroidal antiinflammatory drugs, and opioids for low back pain was measured. The primary outcomes were low back pain intensity and back related functioning measured with a numerical rating scale and the Roland Morris Disability Questionnaire, respectively.