In late 2020, the Royal College of Physicians (RCP) established the Inequalities in Health Alliance (IHA) to campaign for a cross-government strategy to reduce health inequalities. selleck chemicals In this article, RCP president Prof Andrew Goddard charts the evolution of the IHA and explains what comes next. Mild cognitive impairment (MCI) is a condition that entails a slight yet noticeable decline in cognition that exceeds normal age-related changes. Older adults living with MCI have a higher chance of progressing to dementia, which warrants regular cognitive follow-up at memory clinics. However, due to time and resource constraints, this follow-up is conducted at separate moments in time with large intervals in between. Casual games, embedded into the daily life of older adults, may prove to be a less resource-intensive medium that yields continuous and rich data on a patient's cognition. To explore whether digital biomarkers of cognitive performance, found in the casual card game Klondike Solitaire, can be used to train machine-learning models to discern games played by older adults living with MCI from their healthy counterparts. Digital biomarkers of cognitive performance were captured from 23 healthy older adults and 23 older adults living with MCI, each playing 3 games of Solitaire with 3 different d The digital biomarkers derived from Klondike Solitaire show promise and may prove useful to fill the current blind spot between consultations. Real-time digital heart rate (HR) monitoring in sports can provide unique physiological insights into athletic performance. However, most HR monitoring of elite athletes is limited to non-real-time, non-competition settings while utilizing sensors that are cumbersome. The present study was undertaken to test the feasibility of using small, wearable medical-grade sensors, paired with a novel technology system, to capture and process real-time HR data from elite athletes during professional competition. We examined the performance of the BioStamp nPoint® sensor compared to the Polar chest strap HR sensor in 15 Professional Squash Association (PSA) tournament matches in 2019-2020. Fourteen male professional squash players volunteered for the study (age = 23.8 ± 4.9 years; height = 177.9 ± 7.1 cm; weight = 71 ± 7.0 kg), which was approved by the PSA in accordance with their Code of General Conduct and Ethics. Algorithms developed by Sports Data Labs (SDL; Detroit, MI, USA) used proprietary data collection, trc performance and physical and psychosocial demands in elite athletic competition.It is feasible to accurately measure and monitor real-time HR in elite athletes during competition using BioStamp's and SDL's proprietary system. This system facilitates development and understanding of physiological digital biomarkers of athletic performance and physical and psychosocial demands in elite athletic competition.The Coalition for African Rice Development (CARD) was initiated as a policy framework with the aim of doubling rice production in sub-Saharan Africa (SSA) over the period from 2008 to 2018. This paper assesses the contribution of the CARD policy to rice production and forecasts the local rice supply and demand to provide a better understanding of the policies needed to attain rice self-sufficiency by 2030. A combination of the autoregressive integrated moving average method and counterfactual approach was adopted using rice statistical data from 23 countries in SSA. The results showed that the contribution of CARD to paddy rice production in 2018 was 10.2 million tons, equivalent to 74% of the target. This contribution resulted from increases in area and yield of 23% and 19%, respectively. However, the yield growth rate was not sustainable in almost two-thirds of countries. Investments in supply-push factors such as fertilizer and irrigation development, which were the focus in the past, have limited effects on rice production. We conclude that sustainable investments in demand-pull factors such as the private-led modern milling sector and contract farming development should be prioritized to achieve rice self-sufficiency in SSA. We sought to evaluate the effectiveness of a community health worker (CHW) led smoking cessation intervention, supplemented by text messages, and tailored to an individual's readiness to quit. We conducted a cluster randomized controlled trial (April 2018-August 2019) in adult smokers residing in a semi-urban region of India. Participants in the intervention arm received CHW-led home visits and had the option of choosing to receive regular text messages. The dose and content of CHW counseling and text messages were tailored to the participant's readiness to quit. The control group received brief education only. Primary outcome was biochemically verified smoking cessation at the end of 12 months. Both intention-to-treat and as-treated analyses were performed. A total of 238 (mean age 43±12.3 years, male 96.2%) participants were enrolled; 151 (64%) in the intervention arm and 83 (35.4%) in the control arm. At 12 months, 31 (20.5%) participants in the intervention arm and 9 (10.8%) in the control arm quit ing.Hearing screening for newborn babies is an established protocol in many high-income countries. Implementing such screening has yielded significant socioeconomic advantages at both an individual and societal level. This has yet to permeate low/middle-income countries (LMIC). Here, we illustrate how newborn hearing screening needs to be contextually adapted for effective utilisation and implementation in an LMIC. Specifically, this advocates the use of auditory brainstem testing as the first-line approach. We propose that such adaptation serves to maximise clinical efficacy and community participation at a reduced cost.Background Assessment of the effectiveness of tuberculosis control strategies requires the periodic measurement of M. tuberculosis transmission in populations, which is notoriously difficult. One well-established method is to measure the prevalence of infectious pulmonary tuberculosis in the population which is then repeated at a second time point after a period of 'intervention', such as scale up of the Search-Treat-Prevent strategy of the Zero TB Cities initiative, allowing for a 'before and after' comparison. Protocol The concurrent adult pulmonary tuberculosis prevalence survey (using digital radiography and Xpert MTB/RIF Ultra) and child M. tuberculosis infection survey (using QuantiFERON-TB® Gold Plus) will primarily provide a baseline measure of the burden of adult infectious tuberculosis in Karachi and assess whether a large-scale interferon gamma release assay survey in children aged 2 to 4 years is feasible. The target population for the prevalence survey is comprised of a stratified random sample of all adults aged 15 years and above and all children aged 2 to 4 years resident in four districts in Karachi.