0% vs 121 of 474, 25.5%; P < .001) and were more likely to undergo appropriate management of actionable findings compared with patients in the unflagged group (23 of 62, 37.1% vs 28 of 129, 21.7%; P= .036). Implementation of a structured discrete field element for reporting of patients with incidental pancreatic findings had positive impact on surveillance measures and can be applied in other organ systems with established surveillance guidelines to standardize patient care.Implementation of a structured discrete field element for reporting of patients with incidental pancreatic findings had positive impact on surveillance measures and can be applied in other organ systems with established surveillance guidelines to standardize patient care. To evaluate outcomes of botulinum toxin (BTX) injection of the inferior oblique (IO) muscles. Retrospective case series. Single center, ophthalmology department at Boston Children's Hospital STUDY POPULATION All patients treated with IO muscle injection of BTX (onabotulinumtoxinA) between 2010 and 2020. Sensorimotor evaluations at short-term (<2 months), medium-term (2-4 months), and long-term (≥4 months) intervals. Primary outcomes included median improvement in V-pattern strabismus and primary position hypertropia. Secondary outcomes included IO overaction. Wilcoxon signed-rank tests were performed to identify differences pre- and post-injection. Record review identified 20 patients with median age 4.5 [range 1-69] years. Median BTX dose injected (31 IO muscles) was 5.0 [range 3.0-7.0] units. Indications included V-pattern strabismus (N=8), hypertropia (N=7), or both (N=5). Median long-term interval was 6.4 months [range 4.1-26.6]. Injections were concurrent with treatment of horizontal strabismus in all but 3 cases. Median V-pattern magnitude changed from 10 PD pre-operatively to 0 PD short-term (p=0.006) and 3.5 PD long-term (p = 0.34). Median hypertropia changed from 8.5 PD pre-operatively to 1.5 PD short-term (p=0.01) and 8 PD long-term (p=0.87). Median IO overaction grade improved significantly at short-term (p<0.001) and long-term (p=0.007) intervals. There were no complications associated with the IO injections. BTX injection of the IO muscles can be a useful adjunct to the management of V-pattern strabismus. Intervention for primary position hypertropia may be helpful for short-term relief with no expectation of long-term benefit.BTX injection of the IO muscles can be a useful adjunct to the management of V-pattern strabismus. Intervention for primary position hypertropia may be helpful for short-term relief with no expectation of long-term benefit. This study examines the relationship between fluctuations in central subfield thickness (CST) and visual acuity in patients with diabetic macular edema (DME) using data from two large clinical trials. Clinical cohort study using post hoc analysis of clinical trial databases. Standard deviation (SD) of all recorded CSTs for each patient during the study period were used to quantify the fluctuations in CST. Patients from each protocol were grouped into quartiles based on the CST SD. Eyes with at least 3 CSTs and visual acuity (VA) at 1 year were included. The main outcome measures were VA at 1 and 2 years for each Protocol, stratified by SD quartile. A total of 1,197 eyes were included in the analysis. There were significant VA differences based on CST SD quartile for both Protocols while adjusting for mean baseline VA, baseline CST, lens status, hemoglobin A1c, and treatment arm. At week 52 in Protocol T, the difference between the first and fourth quartiles was -1.61 Early Treatment Diabetic Retinopathy Study (ETDRS) letters (95% CI, -3.52 to 0.30, p = 0.0986). At week 104 this difference was -3.59 letters (95% CI, -6.17 to -1.00, p = 0.0066). In Protocol V at week 52 the difference between the first and fourth quartiles was -3.04 letters (95% CI, -4.18 to -1.91, p <0.0001). At week 104 this difference was -2.35 letters (95% CI, -3.58 to -1.13, p = 0.0005). Large fluctuations in CST may portend worse VA outcomes at the 2 year endpoint in patients with DME.Large fluctuations in CST may portend worse VA outcomes at the 2 year endpoint in patients with DME. To evaluate anatomical and functional inter-eye symmetry among individuals with Bietti Crystalline Dystrophy (BCD) using clinical and multi-modal imaging methods, with a focus on the number, area, and distribution of the characteristic retinal crystalline deposits. Observational case series with prospective and retrospective data. Setting Multicenter STUDY POPULATION Thirteen Australian and New Zealand participants (26 eyes) with confirmed biallelic CYP4V2 mutations and a characteristic BCD fundus appearance. Crystals visible on color fundus photography were manually counted. Crystals were superimposed on aligned multimodal fundus images. Spearman's correlation coefficients (ρ), intraclass correlation coefficients (ICCs), and Bland-Altman plots were used to quantify symmetry between eyes. Fundus crystal area and count, and absent-autofluorescence (absent-AF) area. Median participant age was 48 years, interquartile range 40-60 years. Inter-eye symmetry was high for fundus crystal area (ρ=1.00, 95% nvolved in the care and counselling of BCD patients. To quantitatively evaluate the retinal structural parameters of pediatric patients who were determined to be deficient in vitamin D. Prospective, cross-sectional study METHODS Retinal structural parameters, including the peripapillary retinal nerve fiber layer (RNFL), central macula, retinal layer, and choroidal thicknesses, central retinal artery equivalent (CRAE), and central retinal vein equivalent (CRVE), in pediatric subjects with vitamin D deficiency (Group 1) and those without (Group 2) were compared. Group 1 comprised 70 individuals, while Group 2 comprised 80 individuals. SD-36 The mean peripapillary RNFL [except for the nasal superior sector (p =0.037)], central macula, and retinal layer thicknesses were also determined to be similar in both of the groups (p >0.05 for both groups). The mean choroidal thickness was lower in the subfoveal (p =0.006) and nasal 3000-µm-diameter areas (p =0.004) in Group 1. The mean CRAE was determined to be lower (p =0.031) and the CRVE was higher in Group 1 (p =0.005); it was determined that there was a significant correlation between the vitamin D level and both the CRAE (r = 0.