85 (95%CI 1.8 to 13.06, p  less then  .01), area under curve (AUC) 0.65) and neurological outcome (fully-adjusted odds ratio 3.96 (95%CI 1.47 to 10.66, p  less then  .01), AUC 0.63). CONCLUSIONS ACs are interesting surrogate biomarkers that are associated with mortality and poor neurological outcome in patients after OHCA and may help to improve the understanding of pathophysiological mechanisms and risk stratification. Gastropod shells may present large spines and sharp shapes that vary according to environmental, taxonomic, and evolutionary factors. In these cases, classic morphometric methods used to study shell contour might not provide a clear representation of morphological shell based on angular decomposition of contour. The present study analyzed and compared for the first time the robustness of the contour analysis using wavelet transformed and Elliptic Fourier descriptors for gastropod shells including enlarged spines. For that, we analyzed two geographical and ecological separated populations of Bolinus brandaris from the NW Mediterranean Sea. Results showed that contour analysis of gastropod shells with enlarged spines can be analyzed using both methodologies, but the wavelet analysis provided a better local discrimination. From an ecological perspective, shells with spines of different sizes were observed in both localities suggesting a wide plasticity of the species. Geckos are exceptional at terrestrial locomotion and can move on diverse terrains and surface orientations. Geckos employ cyclical lateral bending of their flexible trunk and tail to coordinate their limb movements. In this study, using an optical motion capture system, we measured the kinematics of this lateral undulation pattern of geckos (Gekko gecko) at increasing locomotion velocity on horizontal plane, 45° inclined plane and vertical plane, respectively. We observed that geckos increased their stride frequency and stride length to increase the locomotion velocity; the effect of stride frequency on the locomotion velocity was greater than that of stride length. With increasing speed, the lateral undulation pattern changed from standing to travelling. The waveform of the trunk movement appeared as single-peak curves in a standing wave at low speeds and was propagated from head to tail in a travelling wave at high speeds. Analysis of the anatomical characteristics and axial angular kinematics of the two patterns revealed that the lateral undulation pattern results from girdle rotation and axial muscle activity. GSK269962A clinical trial Thus, the travelling wave is the combined effect of the lateral trunk bending and deflection of the body relative to the motion direction. Progesterone (P4) is an extensively applied progestin in human and veterinary medicine that has been widely detected in ambient aquatic environments, which can be detrimental to the health of aquatic organisms. Here we investigate the long-term effects of P4 on the transcription of genes related to the circadian rhythm signaling pathway and hypothalamic-pituitary-gonadal (HPG) axes in the crucian carp, which may have a potentially negative on endocrine-disrupting and sex differentiation impacts. Our results suggest that the expression of genes associated with the circadian rhythm signaling pathway are altered following exposure for 10, 20, 30, 40, 50 and 60 d, leading to disorders in the endocrine system disorders and the regulation of HPG axes-related gene expression. These maladies may affect gonadal development and the reproductive systems of crucian carp and provide a plausible mechanism for the observed change in sex ratio toward females after 180 d. There is an important need to increase knowledge regarding the interactions between environmental contaminants and other compounds. Pesticides are an important group of food contaminants. By contrast, cichoric acid (CA) belongs to the category of desirable food ingredients with antioxidant and cytotoxic effects. The aim of the presented study was to test if CA may constitute a food ingredient, which eliminate stimulatory effect of pesticides on skin cancer cells and toxic effect of herbicides on fibroblasts. Therefore, we conducted cytotoxicity studies of environmentally relevant pesticide concentrations and the mixture of both compounds in melanoma and fibroblasts cells. We studied if CA combined with mesotrione change the oxidative stress parameters and apoptotic activity in treated cells. Obtained results indicate that CA exhibits cytotoxic activity against mesotrione-induced skin cancer development by influencing oxidative stress parameters and apoptosis. On the other hand CA inhibits prooxidative and proapoptotic activity of mesotrione in fibroblasts. Presented methods and obtained results could be a useful tool in the analysis of environmental contaminants toxicity and possible preventive activity of antioxidative plant- origin compounds. OBJECTIVES With a steadily increasing thyroid cancer incidence, information regarding cancer aggressiveness is essential to determine which patients may be suitable for active surveillance. This study assessed the extent of non-aggressiveness of untreated, local and regional stage, papillary thyroid cancer. MATERIALS AND METHODS We used the Surveillance, Epidemiology, and End Results (SEER) registry and included 1423 local stage and 337 regional stage papillary thyroid cancer cases. Thyroid cancer specific survival was estimated conditional on the absence of death due to competing causes using competing risk methods. Stratified analyses were done to determine non-aggressiveness among different patient and tumor characteristics. RESULTS The overall rate of non-aggressiveness for local stage thyroid cancer was 99.34% (95% CI 99.33-99.35%), with a rate of non-aggressiveness of 98.85% (95% CI 98.77-98.93%) for males and 99.48% (95% CI 99.46-99.49%) for females (p = 0.055). Rate of non-aggressiveness was significantly lower in patients >60 years compared to patients ≤60 years (p 20 mm had a significantly lower rate of non-aggressiveness (p = 0.002). The overall rate of non-aggressiveness for regional stage thyroid cancer was 72.58% (95% CI 70.61-74.56%). CONCLUSION We found high rates of non-aggressiveness in untreated, local stage, papillary thyroid cancer, particularly in younger patients with small (≤2 cm) thyroid cancer, suggesting that these patients may be good candidates for active surveillance.