Three-dimensional (3D) transesophageal echocardiography (TEE) is one of the most significant advances in cardiac imaging. Although TEE provides real-time 3D visualization of heart tissues and blood vessels and has no ionizing radiation, x-ray fluoroscopy still dominates in guidance of cardiac interventions due to TEE having a limited field of view and poor visualization of surgical instruments. Therefore, fusing 3D echo with live x-ray images can provide a better guidance solution. This paper proposes a novel framework for image fusion by detecting the pose of the TEE probe in x-ray images in real-time. The framework does not require any manual initialization. Instead it uses a cascade classifier to compute the position and in-plane rotation angle of the TEE probe. The remaining degrees of freedom are determined by fast marching against a template library. The proposed framework is validated on phantoms and patient data. The target registration error for the phantom was 2.1 mm. In addition, 10 patient datasets, seven of which were acquired from cardiac electrophysiology procedures and three from trans-catheter aortic valve implantation procedures, were used to test the clinical feasibility as well as accuracy. A mean registration error of 2.6 mm was achieved, which is well within typical clinical requirements.Integration of electrical contact into two-dimensional heterostructure is an essential key to approach high-quality electronic nano-devices, especially field-effect transistors. However, high contact resistance with transition metal dichalcogenides such as molybdenum disulphide (MoS2) based devices has been a significant fabrication impediment to their potential applications. Here, we have demonstrated the advantage of one-dimensional indium metal contact with fully encapsulated MoS2within hexagonal boron nitride. The electrical measurements of device exhibit ambipolar transport with an on/off ratio of 104for holes and 107for electrons. The presence of ambipolar transport in MoS2illustrates that the pinned Fermi level of MoS2has been de-pinned to some extent by virtue of indium edge contact, thus enabling us to access electrons as well as holes. Z-VAD(OH)-FMK datasheet The device exhibits high field-effect mobility of 40.7 cm2V-1s-1at liquid nitrogen temperature. Further, we have also analysed the charge transport mechanism at the interface and have calculated the Schottky barrier height from the temperature-dependent measurement. These results are highly promising for the use of air sensitive materials heterostructure and large-scale design of trending flexible, transparent electronic wearable devices.Low temperature magnetization of CrI3, CrSiTe3and CrGeTe3single crystals were systematically studied. Based on the temperature dependence of extrapolated spontaneous magnetization from magnetic isotherms measured at different temperatures, the spin stiffness constant (D) and spin excitation gap (Δ) were extracted according to Bloch's law. For spin stiffness,Dis estimated to be 27 ± 6 meV Å2, 20 ± 3 meV Å2and 38 ± 7 meV Å2for CrI3, CrSiTe3and CrGeTe3respectively. Spin excitation gaps determined via Bloch's formulation have larger error bars yielding 0.59 ± 0.34 meV (CrI3), 0.37 ± 0.22 meV (CrSiTe3) and 0.28 ± 0.19 meV (CrGeTe3). Among all three studied compounds, larger spin stiffness value leads to higher ferromagnetic transition temperature.Dual-modal molecular imaging that combines photoacoustic imaging with near-infrared fluorescence imaging integrates the benefits of both imaging modalities and may achieve more precise detection of disease. In this study, silver sulfide quantum dots (Ag2S QDs) with superior photoacoustic properties and a strong fluorescent emission in the NIR region were successfully synthesized. They were further modified with the insulin-like growth factor 1 receptor (IGF-1R) targeted small scaffold protein, Affibody (ZIGF-1) to achieved targeted photoacoustic/fluorescent dual-modal imaging of cancer. Our results showed that the prepared nanoprobe had good tumor targeting properties in vivo, and the probe also showed good biocompatibility without any significant toxicity.Two-dimensional (2D) nanosheets doped with silver nanoparticles (AgNPs) have found significant antibacterial applications in industry. In this work, synthesis of graphene oxide (GO) and reduced graphene oxide (rGO) was realized through a modified Hummers route. Different concentrations (5 & 10 wt.%) of Ag were doped in MoS2 and rGO using a hydrothermal approach. Synthesized Ag-MoS2 and Ag-rGO were evaluated through XRD that confirmed the hexagonal structure of MoS2 along with the transformation of GO to Ag-rGO as indicated by a shift in XRD peaks. FTIR confirmed the presence of Mo-O bonding vibrations, and S=O functional groups present in the prepared samples. Morphological information of GO and formation of MoS2 nanopetals were verified through FESEM, while spherical morphology, interlayer spacing, and homogeneous distribution of AgNPs were scrutinized through HR-TEM. Raman analysis was employed to probe any evidence regarding defect densities of GO. Optical properties of GO, MoS2, Ag-rGO, and Ag-MoS2 were visualized through UV-Vis & PL spectroscopy. Prepared products were employed as nanocatalysts to purify industrial wastewater, while degradation of undoped and doped samples was inspected using UV-Vis spectroscopy. Experimental results revealed that the photocatalytic response of Ag-rGO and Ag-MoS2 enhanced upon doping. Besides, the nanocatalyst (Ag-MoS2 & Ag-rGO) exhibited an excellent antibacterial activity towards S. aureus gram positive (G+) and E. coli gram negative (G-). To rationalize biocidal mechanism of Ag-doped MoS2 NPs and Ag-rGO, in silico molecular docking study was employed for two enzymes (i.e. β-lactamase & ddlB) from cell wall biosynthetic pathway and FabI from fatty acid biosynthetic pathway belonging to S. aureus. The present study provides evidence for the development of cost-effective and environmental-friendly products that could receive favorable recommendation for use in industrial and biomedical applications.In the era of COVID-19 outbreak, various efforts are undertaken to develop a quick, easy, inexpensive, and accurate way for diagnosis. Although many commercial diagnostic kits are available, detailed scientific evaluation is lacking, making the public vulnerable to fear of false-positive results. Moreover, current tissue sampling method from respiratory tract requires personal contact of medical staff with a potential asymptomatic SARSCOV-2 carrier and calls for safe and less invasive sampling method. Here, we have developed a convenient detection protocol for SARS-COV-2 based on a non-invasive saliva self-sampling method by extending our previous studies on development of a laboratory-safe and low-cost detection protocol based on qRT-PCR. We tested and compared various self-sampling methods of self-pharyngeal swab and self-saliva sampling from non-carrier volunteers. We found that the self-saliva sampling procedure gave expected negative results from all of the non-carrier volunteers within 2 hours, indicating cost-effectiveness, speed and reliability of the saliva-based method.