Our results pave the way toward robust and efficient ignition of lean-fuel engines by ultrashort-pulsed lasers.BACKGROUND Gastrointestinal stromal tumors (GISTs) are rare mesenchymal cancers that affect the gastrointestinal tract and are most often located in the stomach and proximal small intestine. The most common molecular genetic abnormalities underlying GIST carcinogenesis are mutations in the tyrosine kinase gene (KIT) and in the platelet-derived growth factor receptor alpha (PDGFRA) gene. To the best of our knowledge, no cases have been reported so far of synchronous diagnosis of GIST in 2 monozygotic twins presenting with clinical and morphological features of sporadic disease. CASE REPORT This report presents the cases of 2 monozygotic twin sisters who were diagnosed with GIST at the same age and who had different KIT exon 11 tumor mutational statuses. In the current report, the screening examination that led to early detection of GIST in one of the sisters was not motivated by any symptom, but by a GIST diagnosis in her twin a few days before. The literature was reviewed for pathological and molecular features associated with prognosis and treatment response. Furthermore, we identified identical genotypes of KIT and PDGFRA polymorphisms in the DNA of both tumors that might be present in the germline DNA. The present case supports the implementation of specific cancer screening in the context of monozygotic twins, regardless of identification of the genetic components involved. CONCLUSIONS Our report suggests that monozygotic twins with GIST can have different mutational statuses for KIT and PDGFRA. Referral for special screening should be considered for individuals who have a monozygotic twin diagnosed with cancer.BACKGROUND The vestibular disorders activities of daily living (VADL) scale is a valid and reliable scale created 2 decades ago to specifically test the functional problems of patients with vestibular disorders. Since its development, the VADL has been cross-culturally validated and adapted in Spanish, Portuguese, Persian, and Turkish languages. A version is not yet available in Arabic, the primary language of more than 400 million people worldwide. This study aimed to translate the patient-reported VADL into Arabic and test its psychometric properties such as content validity, internal consistency, and test-retest reliability. MATERIAL AND METHODS Our study was conducted in 2 parts. In the first part, we translated and adapted the VADL from English into Arabic with expert input. In the second part, we tested the translated scale content validity by consulting 6 experts in the field. We assessed the scale's internal consistency and test-retest reliability by administering it twice to 31 subjects with vestibular disorders with a 1-week interval between the 2 measurements. RESULTS Translation, adaptation, and pretesting were successful, and we were able to create the VADL-A, an Arabic version of the VADL. The content validity of the VADL-A was 0.96, internal consistency was 0.96, and the test-retest reliability was 0.93. CONCLUSIONS We successfully translated, adapted, and created the VADL-A. Our preliminary testing of basic psychometric properties indicated that the scale has excellent content validity, internal consistency, and test-retest reliability. Lesbian and bisexual women may be at an increased risk for gynecologic infections and breast cancer due to a higher prevalence of factors such as obesity, smoking, and lower pregnancy rates. selleck chemical This article discusses the role of healthcare professionals in preventive screening for breast and gynecologic cancers and promoting healthy living in these patients by avoiding smoking, maintaining an ideal body weight, and limiting alcohol consumption.Lesbian and bisexual women may be at an increased risk for gynecologic infections and breast cancer due to a higher prevalence of factors such as obesity, smoking, and lower pregnancy rates. This article discusses the role of healthcare professionals in preventive screening for breast and gynecologic cancers and promoting healthy living in these patients by avoiding smoking, maintaining an ideal body weight, and limiting alcohol consumption. To support evidence-based nursing practice, the authors provide guidelines for nonresearch evidence, which includes clinical practice guidelines, consensus or position statements, literature review, expert opinion, organizational experience, case reports, community standards, clinician experience, and consumer preferences. This is the third in a three-part series.To support evidence-based nursing practice, the authors provide guidelines for nonresearch evidence, which includes clinical practice guidelines, consensus or position statements, literature review, expert opinion, organizational experience, case reports, community standards, clinician experience, and consumer preferences. This is the third in a three-part series. Bacterial vaginosis increases the risk of sexually transmitted infections, including HIV, and treatment is crucial to avoid complications. This article reviews the evidence-based options for treating bacterial vaginosis to improve patient outcomes.Bacterial vaginosis increases the risk of sexually transmitted infections, including HIV, and treatment is crucial to avoid complications. This article reviews the evidence-based options for treating bacterial vaginosis to improve patient outcomes. Advice from current nurse leaders can offer valuable insight for aspiring leaders. This article discusses how the collective wisdom of practicing nurse leaders can assist new leaders as they transition into the role.Advice from current nurse leaders can offer valuable insight for aspiring leaders. This article discusses how the collective wisdom of practicing nurse leaders can assist new leaders as they transition into the role. There are an estimated 4.8 million victims of sex trafficking (ST) globally, and 21% of these victims are children or adolescents. Victims of ST are at risk for mental health problems, and it is crucial for healthcare professionals to identify them and provide care.There are an estimated 4.8 million victims of sex trafficking (ST) globally, and 21% of these victims are children or adolescents. Victims of ST are at risk for mental health problems, and it is crucial for healthcare professionals to identify them and provide care.