The aim of the study was to evaluate the influence of endovascular therapy (EVT) on the acute ischemic stroke (AIS) secondary to carotid artery dissection (CAD). This single-center retrospective study enrolled 17 patients admitted with AIS secondary to CAD from January 2018 to November 2019 in the Department of Neurology, Shenzhen Hospital of Southern Medical University where patients received EVT with guidewire or parallel guidewire. Outcomes including postoperative complications were recorded, the prognostic factors of patients were explored, and the effectiveness of single guidewire versus parallel guidewire on EVT was compared. Before treatment, the mean National Institute of Health stroke scale (NIHSS) was 14.4 in 10 cases (58.8%) of CAD complicated with intracranial artery embolism. All patients underwent EVT, and the success rate of operation was 100%. ICI-182780 After all interventions, modified thrombolysis in cerebral ischemia (mTICI) 3 reperfusion was achieved in 14 patients (82.4%), and mTICI 2b reperfusion was achieved in 3 (17.6%). One patient had cerebral infarction and edema complicated with cerebral hernia, one patient had cerebral hemorrhage, one patient had complicated subarachnoid hemorrhage, and five cases had asymptomatic cerebral hemorrhage. Three months after treatment, 14 cases (82.3%) achieved a good clinical outcome (modified Rankin scale, mRS 0-2). Puncture-to-reperfusion time in the parallel guidewire group was significantly shorter than that of the single guidewire group. However, the differences in NIHSS score, postoperative mTICI, and mRS score between both groups did not reach significance. CAD patients receiving EVT have a good prognosis, and application of a parallel guidewire can reduce operation time.CAD patients receiving EVT have a good prognosis, and application of a parallel guidewire can reduce operation time. The technique of sampling is a particularly important aspect of sampling surveys, and the method of determining sample size is the key link in sampling technique. However, a sample size determination method for complex sampling surveys of sensitive issues using a randomized response model is not yet available. In this work, we drew from the theory of probability and mathematical statistics, and developed a series of formulas for sample size determination that are required to estimate the overall proportion and mean on dichotomous sensitive questions in 3-stage sampling using Simmons models. Shortly after generating the formulas, we successfully applied them to a pre-survey regarding sensitive issues among female sex workers (FSWs) in Xichang, and found their practical application to achieve satisfactory effects. By using a large number of Monte Carlo simulation sampling tests, the reliability of the survey methods and formulas for sensitive question surveys were found to be high, but the randomized response technique (RRT) cannot completely eliminate the possibility of social acceptability bias. RRT is an acceptable method for sensitive question surveys within sensitive populations, and this new sampling method is liable to be used for sensitive question surveys of large populations. We believe that the results obtained in the field of public health can provide some data support for clinical practice.RRT is an acceptable method for sensitive question surveys within sensitive populations, and this new sampling method is liable to be used for sensitive question surveys of large populations. We believe that the results obtained in the field of public health can provide some data support for clinical practice.Pulmonary tumor thrombotic microangiopathy (PTTM) is a rare but severe pulmonary complication of malignant tumors. It is characterized by the presence of multiple microscopic tumor emboli attached to the endothelium of small pulmonary arteries and induces fibrointimal proliferation and the activation of coagulation. The main clinical manifestations of PTTM are dyspnea, dry cough, hypoxemia, pulmonary hypertension, right heart failure, thrombocytopenia, and disseminated intravascular coagulation (DIC). Chest computed tomography (CT) shows no distinctive findings, and PTTM is often unrecognized and universally underdiagnosed, with an appalling prognosis. An antemortem diagnosis of PTTM is also difficult due to a lack of specific clinical and imaging features. Moreover, there is presently no therapeutic management and the illness rapidly progresses to death. Early identification and timely and effective use of oncotherapy can help to alleviate symptoms and improve prognosis. According to recent reports, targeting angiogenesis factors including platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF) have marginally improved survival. In this article, we report the case of a patient with advanced lung adenocarcinoma complicated with PTTM and DIC. A combined therapeutic regimen of bevacizumab with pemetrexed successfully improved chest CT findings, respiratory symptoms, DIC, and short-term outcomes. Anti-angiogenesis drugs modify the pulmonary vascular structure, and rapidly improve the lung tumor microenvironment. And therefore, it may be a potentially effective drug for the treatment of PTTM.Thyroid metastatic cancer is rare. It may be ignored due to the longer course of the primary disease and the less obvious symptoms. With the popularity of ultrasonography, it can help the early detection of thyroid metastatic cancer. In this case, a 50-year-old woman was diagnosed with thyroid metastasis due to a "decade of lung cancer". The main clinical manifestation of the patient was that although the thyroid area was not enlarged, the texture was stiff. Unlike common thyroid cancer, this patient did not experience hoarseness. The patient underwent ultrasound-guided biopsy of the thyroid area and examined the pathological section. Unlike previous ultrasound manifestations of common thyroid metastatic cancer, the ultrasound results in this case were shown as diffuse, point-like hyperechoic. Ultrasound-guided biopsy of the thyroid site was performed on the patient, and pathological sections were examined. The obtained thyroid pathology section results are shown that metastases of poorly differentiated cancers, tending to adenocarcinoma, considering metastasis in combination with history.