Patients who received any cirAE treatment had improved progression-free survival [hazard ratio (HR) 0·59, P=0·001] and overall survival (HR 0·58, P=0·007) compared with those who did not. CirAEs evaluated by dermatologists were significantly more likely to be treated than cirAEs that were not referred, and patients who received any treatment for a cirAE had improved survival outcomes.CirAEs evaluated by dermatologists were significantly more likely to be treated than cirAEs that were not referred, and patients who received any treatment for a cirAE had improved survival outcomes. The influence of cardiovascular risk factors on the probability of cardiovascular diseases in migraineurs is still being discussed. To further elucidate the mechanisms of these relationships, we assessed the associations between migraine and cardiovascular risk factors, including those that have been recently shown to improve the prediction of cardiovascular events. We used the data of the Finnish Health 2000 Survey (BRIF8901), consisting of 5737 subjects aged 30years or older. In total, 488 participants reported migraine. In addition to conventional cardiovascular risk factors, educational attainment, presence of electrocardiographic signs of left ventricular hypertrophy and hemoglobin A1c were also included in the logistic regression analyses. Migraine was found to be associated with female sex (Odds ratio (OR)=3.75, p<.001), lower age (B=0.99, p<.001), lower high-density lipoprotein cholesterol (OR=1.23, p<.05), higher diastolic blood pressure (OR=1.31, p<.05), and left ventricular hypertrophy (OR=1.32, p<.05), the probability of the last one increasing with migraine attack frequency. Left ventricular hypertrophy, most probably as a consequence of migraine-related arterial hypertension and dyslipidemia, may play a role in the relationship between migraine and cardiovascular events. selleck chemical The nature of this finding calls for further studies.Left ventricular hypertrophy, most probably as a consequence of migraine-related arterial hypertension and dyslipidemia, may play a role in the relationship between migraine and cardiovascular events. The nature of this finding calls for further studies.The aim of this scoping review was to summarise current knowledge about the effects of bone anabolic drugs on periodontitis, in order to identify new therapeutic strategies for preventing disease progression and reducing tooth loss. A technical expert panel (TEP) was established of 11 medical specialists, including periodontists and bone specialists that followed the PRISMA-ScR model to perform the scoping review and considered for eligibility both pre-clinical and clinical studies published in the English language up to September 2020. 716 items were initially found. After duplicate removal and screening of articles for eligibility criteria, 25 articles published between 2001 and 2019 were selected. Only studies concerning teriparatide, strontium ranelate, sclerostin antibodies and DKK1 antibodies met the eligibility criteria. In particular, only for teriparatide were there both clinical studies and experimental studies available, while for other bone anabolic drugs only animal studies were found. Available evidence about the use of bone anabolic drugs in periodontology demonstrates beneficial effects of these agents on biological pathways and histological parameters involved in periodontal tissue regeneration that suggest relevant clinical implications for the management of periodontitis. Als Reaktion auf die Corona-Pandemie fand im Frühjahr 2020 ein gesellschaftlicher Stillstand statt. Untersucht werden soll, wie diese Pandemie-Maßnahme auf die Bevölkerung eines ländlich geprägten, strukturschwachen Bundeslandes am Beispiel der Notaufnahmefallzahlen eines Schwerpunktversorgers gewirkt hat. Abruf von anonymisierten aggregierten Routinedaten und Auswertung der Phasen "Vergleich" (03.07.2019-15.03.2020), Corona-Phase 1" (16.03.2020-06.05.2020) und "Corona-Phase 2" (07.05.2020-31.07.2020). Auswertung von 24977 Patientendaten (2493 Patienten Corona-Phase 1/5106 Patienten Phase 2). 53% der Patienten sind älter als 50 Jahre, ca. 30% älter als 70 Jahre. Regulär suchen 67,6 Patienten die Notaufnahme je Tag auf. In der Corona-Phase 1 reduziert sich die Zahl um 19,7 Patienten/Tag; in der Phase 2 sind 8,2 Patienten/Tag weniger als in der Vergleichsgruppe - bei insgesamt unveränderter Altersstruktur. 56% der Patienten suchen eigenständig (Selbstvorstellung) die Notaufnahme auf, 24% auf Veranlassung esented to the ED by themselves or referred by the GP - these were more than those brought into the ED by the rescue service. Based on literature and our own data, we suspect the lockdown restrictions could be responsible for the observed decrease of cases, too. In the context of the mild course of COVID-19 cases in Mecklenburg, these results are surprising. Further studies regarding whether and how the population used the ED should be performed.Access to the ED decreased during the COVID-19 outbreak especially by patients who presented to the ED by themselves or referred by the GP - these were more than those brought into the ED by the rescue service. Based on literature and our own data, we suspect the lockdown restrictions could be responsible for the observed decrease of cases, too. In the context of the mild course of COVID-19 cases in Mecklenburg, these results are surprising. Further studies regarding whether and how the population used the ED should be performed. Ever since the first successful keratoplasty in 1905, there has been a need to store corneas for transplantation. R. Townley Paton founded the first eye bank in New York in 1944. With Helen Keller's call in 1925 for LIONS to "constitute themselves Knights of the Blind in the crusade against darkness", LIONS Clubs International has become involved in the establishment of eye banks worldwide. This paper presents the development of eye banking in general and with special attention to the support offered by LIONS Clubs. Selective literature search through PubMed, Google Scholar and Google in close cooperation with the LIONS Eye Banks already established in Germany, LIONS Clubs International (USA) and the Julius Hirschberg Society (Austria). Analysis focused on the founding processes of 6 German eye banks and their current services. Filatov was the first to keep donor eyes in a cool, moist container for a few days. In 1973, Summerlin et al described the technique of organ culture for donor corneas, and McCarey & Kaufman described a liquid storage medium in 1974.