In summary, the current findings established PHF8 as a novel epigenetic element in developing auditory organs, rendering it a potential candidate for hearing loss therapy.The COVID-19 pandemic has affected various macroeconomic indicators. Given this backdrop, this research investigates the effects of the pandemics-related uncertainty on household consumption. For this purpose, we construct a simple theoretical model to study the effects of the pandemics-related uncertainty on household consumption. To estimate the theoretical model, we consider the panel dataset of 138 countries for the period from 1996 to 2017. We also use the Pandemic Uncertainty Index to measure the pandemics-related uncertainty. The theoretical model and the empirical findings from the Feasible Generalized Least Squares (FGLS) estimations indicate that the gross fixed capital formation, government consumption, balance of trade, and the Pandemic Uncertainty Index negatively affect household consumption. The results are also valid in the panel dataset of 42 high-income economies and the remaining 96 emerging economies. The purpose of this study was to investigate the clinical differences between open reduction and plate fixation via a deltopectoral approach with allogenous fibular bone graft and a minimally invasive plate osteosynthesis (MIPO), in Neer's classification two-, three- part proximal humeral fractures. In this retrospective study, 77 patients with two-, three-part proximal humeral fractures were treated at two different institutions. Clinical and radiological evaluations were performed in 39 patients, who underwent MIPO at one institution (group A), and 38 patients, who underwent a deltopectoral approach with allo-fibular bone graft (group B) at another institution. The results between the groups were compared. The MIPO technique was significantly less time consuming and caused less bleeding than the deltopectoral approach with allo-fibular bone graft (P<0.05). The duration of the fracture union was significantly reduced in group A (14.5±3.4; range, 10-22 weeks) compared to group B (16.4±4.3; range, 12-que.Oral squamous cell carcinoma (OSCC) is an aggressive tumor that has a poor prognosis, with high levels of local invasion and lymph node metastasis. Vascular endothelial growth factor A (VEGF-A) plays essential roles in OSCC tumor angiogenesis and metastasis. Monocyte chemoattractant protein-1 (MCP-1, CCL2) is implicated in various inflammatory conditions and pathological processes, including oral cancer. The existing evidence has failed to confirm any correlation between MCP-1 or VEGF-A expression and OSCC angiogenesis. In this study, high expression levels of MCP-1 and VEGF-A were positively correlated with disease stage in patients with OSCC. In oral cancer cells, MCP-1 increased VEGF-A expression and subsequently promoted angiogenesis; miR-29c mimic reversed MCP-1 activity. We also found that MCP-1 modulated VEGF-A expression and angiogenesis through CCR2/ILK/MEK1/2 signaling. Ex vivo results of the chick embryo chorioallantoic membrane (CAM) assay revealed the angiogenic qualities of MCP-1, with increased numbers of visible blood vessel branches. Our data suggest that MCP-1 is a new molecular therapeutic target for the inhibition of angiogenesis and metastasis in OSCC.Sarcoidosis is defined by granuloma formation in a multitude of organs. Despite its rare involvement in the nervous system, there are a number of cases that identify neurological symptoms to be the initial clinical manifestation of sarcoidosis. The involvement of the hypothalamic-pituitary (HP) axis presented most frequently with hormone deficiencies. Studies have reported that damage to the pituitary gland may be irreversible, and hormone abnormalities were generally permanent. Neurosarcoidosis has been described as the underlying cause of central diabetes insipidus (DI) and syndrome of inappropriate antidiuretic hormone (SIADH) secretion. The pathological mechanism that can lead both to deficiency and excess of antidiuretic hormone (ADH) secretion is still not fully understood. It has been shown that diagnosis of neurosarcoidosis remains challenging, as symptoms can be inconclusive and diagnostic tools are not sufficiently sensitive and specific. Early treatment may potentially reverse pituitary deficiencies, although studies to confirm this hypothesis are minimal. This review article aims to increase knowledge about central DI and SIADH caused by neurosarcoidosis, identify possible difficulties in diagnosis, and discuss the importance of early management. Clinical trials investigating the long-term therapeutic response in patients with HP sarcoidosis are essential, as there are currently no established guidelines for the treatment of neurosarcoidosis.This article had two objectives 1. Identify the Latin American journals in PMC, discriminate them by country, fields of knowledge, and indexations in Scopus and Web of Science (WOS). 2. Identify Colombian journals, especially those that could be potential publications for PMC. To fulfill the objectives, the list of PMC journals, the Scimago Journal & Country Rank (SJR) database, the main WOS collection, the Publindex bibliographic index database were examined and the journals were categorized by field of knowledge, following the classification model of the Organisation for Economic Cooperation and Development (OECD). As a result, it was found that of the 3194 journals indexed in PMC, 40 are from Latin America (1.25%). Of these, 39 are in Scopus and 25 in WOS, 36 are from Brazil and 2 belong to the field of psychology. In Colombia, 275 journals indexed in Publindex were found, 63 belong to the medical and health sciences, biological sciences, and psychology; 27 are found in Scopus, 8 in WOS, and 2 in PMC. It was concluded that there is a low indexation in PMC of Latin American journals and the inclusion of two psychology journals was highlighted. Colombia has quality journals and international recognition that can advance to indexing in MEDLINE and PMC. Vitamin D-dependent rickets type 1A (VDDR1A) is a rare autosomal recessively inherited disorder due to loss-of-function mutations in the gene. encodes an enzyme of 25-hydroxyvitamin D-1α-hydroxylase for converting inactive 25-OHD to biologically active 1,25-(OH) D. To identify underlying genetic defects in patients with VDDR1A. Twelve patients from 7 Turkish and 2 Saudi families were investigated. The coding exons and intron-exon boundaries of the gene were amplified by Polymerase Chain Reaction (PCR) from peripheral lymphocyte DNA. PCR products were directly sequenced. selleck chemicals llc The consequences of c.590G > A mutation were analyzed by and functional analysis. mutations were identified in all the patients. Two novel mutations were identified in two separate families c.171delG (family 7) and c.398_400dupAAT (family 8). The intra-exon deletion of c.171delG resulted in a frameshift and premature stop codon 20 amino acids downstream from the mutation (p.L58Cfs 20). The intra-exon duplication of c.