The number of screen and surveillance tests needed to prevent one cancer death was impacted most by PC risk. A 10% increase in test sensitivity reduced mortality by 1.9% at most. Test specificity is important for the number of surveillance tests. In conclusion, screening reduces PC mortality in all modeled scenarios. The natural disease course and PC risk strongly determines the effectiveness of screening. Test sensitivity seems of lesser influence than specificity. Future research should gain more insight in PC pathobiology to establish the true value of PC screening in high-risk individuals. Consumptive water footprint (CWF) is a comprehensive measure of water consumption by paddy and can be used to assess the impact on freshwater volume. The seasonal water consumption and water footprints of paddy under any irrigation practice vary with changing the transplanting dates. The present study aimed to investigate the impact of shifting transplanting dates on CWFs of paddy under the system of rice intensification (SRI) using a crop model. A medium-duration variety (IR-36) was cultivated during kharif (monsoon) and rabi (non-monsoon) seasons of 2015/16 and 2016/17. The field data were used to calibrate and validate the crop model, Agricultural Production Systems Simulator (APSIM)-Oryza, as well as simulate paddy yield, evapotranspiration and consumptive water footprints (CWFs) under different transplanting dates. The APSIM-Oryza simulated grain yield was found to be closely matched with the observed yield during both calibration (r = 0.98, root-mean-square error < 300 kg ha ) and validation (r = 0.88, root-mean-square error < 400 kg ha ). The seasonal water savings in SRI practice was 18-21% compared to conventional, with an effect of a 20-30% improvement in the yield. The early transplanting on 1 July in kharif and 15 December in rabi can produce maximum grain yields of 4.55 and 5.15 t ha , respectively, with a minimum CWF of 1064 and 855 m t under SRI for the study region. The comparison of yield and CWF scenarios under different transplanting dates revealed the superiority of early transplanting in terms of yield improvement with the least irrigation requirement and CWF under SRI. © 2021 Society of Chemical Industry.The comparison of yield and CWF scenarios under different transplanting dates revealed the superiority of early transplanting in terms of yield improvement with the least irrigation requirement and CWF under SRI. © 2021 Society of Chemical Industry.Non-steroidal anti-inflammatory drugs (NSAIDs) and statin drugs may protect against the development of non-Hodgkin lymphoma (NHL), but data are limited, particularly for NHL subtypes. Xevinapant mw Furthermore, some in vitro, animal and epidemiologic data suggest there may be a synergistic effect of these two agents, but there has been no test of this hypothesis in NHL. We evaluated the self-reported use of NSAIDs and statins in a clinic-based study of 1703 NHL patients and 2199 frequency-matched controls. Unconditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs), adjusted for potential confounding variables. We observed an inverse association of regular use of low-dose aspirin with risk of NHL (OR = 0.82; 95% CI 0.70-0.96) that was stronger with longer duration of use (P  less then  .01). There were no associations for use of regular or extra-strength aspirin, ibuprofen, other NSAIDs, statins or other cholesterol-lowering drugs with NHL risk, while an inverse association with COX-2 inhibitors was equivocal. There was also no interaction of low-dose aspirin and statins on NHL risk. Inverse associations of similar magnitude to all NHL were observed for regular use of low-dose aspirin with diffuse large B-cell, follicular, marginal zone and all other lymphomas, although not all associations were statistically significant. In conclusion, low-dose aspirin but not regular/extra strength aspirin, other NSAIDs or statin use was associated with lower risk of NHL. Beyond the potential for the primary prevention of NHL, these data also point to a role of anti-platelet or other effects of low-dose aspirin in lymphomagenesis that warrant follow-up. Cacao is important for the economy of many countries in the humid tropics. Its quality is affected when fruits are not collected at the optimal harvest point. The aim of this study was to obtain maturity indices for producers to facilitate the timely harvest and improve the development of fermentation and the sensorial quality of cacao. The growth and respiration processes, and the physicochemical changes during the maturation of three cacao genotypes were determined. Physiological follow-ups measuring fruit length and diameter were performed from 30 days after anthesis to fruit deterioration in the tree. Growth equations were obtained, establishing four maturity stages based on days after anthesis, and fruit length and diameter. Nineteen descriptors were used for the characterization, and through Pearson's correlation and principal component analysis (PCA), five descriptors were identified as representative of the maturity stages of the cacao fruit. PCA results and respiration measurements established that stage 3 presented the highest substrate availability for obtaining good fermentation and quality cacao. This stage showed values between 124 and 197 days after anthesis with lengths between 167.7 and 249.73 mm, and diameters between 64.4 and 95.8 mm, according to the locality. Three growth phases of the cacao fruits were established considering days after anthesis. Both the edaphoclimatic conditions and the cacao genotype characteristics influenced this determination. Stage 3 of fruit maturation shows the best physicochemical conditions for good fermentation. © 2021 Society of Chemical Industry.Three growth phases of the cacao fruits were established considering days after anthesis. Both the edaphoclimatic conditions and the cacao genotype characteristics influenced this determination. Stage 3 of fruit maturation shows the best physicochemical conditions for good fermentation. © 2021 Society of Chemical Industry.