Myocardial ischemia may occur as a result of pathophysiological and therapeutical applications such as atherosclerosis, thromboembolism, percutaneous transluminal coronary angioplasty, coronary artery bypass, and transplantation. In this study, we aimed to compare the effects of angiotensin (Ang) II type 2 (AT2 ) selective receptor agonist Compound 21 (C21), MAS receptor agonist AVE 0991, Ang II type 1 (AT1 ) selective receptor blocker losartan, and Ang-converting enzyme inhibitor captopril on haemodynamic parameters and infarct size on myocardial ischemia/reperfusion (MI/R)-induced necrosis in rats. selleck chemicals To induce necrosis in the heart of rats, reperfusion for 2 h following ischemia for 30 min to the descending branch of the left main coronary artery was achieved. C21 (0.03 mg/kg), AVE 0991 (576 μg/kg), losartan (2 mg/kg), and captopril (3 mg/kg) were administered as an intravenous infusion at 10 min before and throughout the ischemia. Then, the infarct size and risk area were calculated from the heart. The percentage of myocardial infarct size to area at risk ratio (%IS/AR) of groups was Control (MI/R) group 48.9 ± 8.8%; C21 group 31.1 ± 7.8%; AVE 0991 group 29.9 ± 4.8%; C21 + AVE 0991 group 28.2 ± 3.3%; Losartan + AVE 0991 group 30.8 ± 5.8%; Captopril + AVE 0991 group 31.7 ± 7.7%. %IS/AR of the drug-treated groups decreased significantly when compared to the MI/R group (P less then 0.05). Our results indicate that the importance of AT1 , AT2 , and MAS receptors in the MI/R injury. Inhibition of Ang II formation by captopril, blockade of AT1 receptor with losartan, and stimulation of AT2 receptor with C21 and MAS receptor with AVE 0991 showed beneficial effects by reducing infarct size. Gaucher disease (GD) is associated with peculiar metabolic abnormalities (ie hypermetabolic state, peripheral insulin resistance, dyslipidaemia), partially reverted by enzyme replacement therapy (ERT) at the expense of weight gain. Such metabolic alterations together with an unhealthy lifestyle acquired by an ageing GD population may favour the development of liver steatosis. We aimed at evaluating the prevalence of significant liver steatosis and at identifying the factors associated with liver steatosis in a cohort of patients with type 1 GD. Twenty adult type 1 GD patients from an Italian academic referral centre were prospectively submitted to vibration-controlled transient elastography (Fibroscan®) with controlled attenuation parameter (CAP); significant steatosis was defined as CAP values ≥250dB/min. Median CAP values were 234 [165-358] dB/min and 8 patients (40%) had significant steatosis. Significant steatosis was associated with indices of adiposity (weight, BMI and waist circumference), high blood pressure, insulin resistance and metabolic syndrome. GD-related variables and dose and duration of ERT were not associated with significant steatosis. In the subgroup of 16 patients on stable ERT for at least 24months, CAP resulted significantly and positively associated with liver stiffness (rho 0.559, P=.024). Significant steatosis is highly prevalent in adult type 1 GD patients and is strongly associated with a worse metabolic profile, featuring metabolic dysfunction-associated fatty liver disease (MAFLD). MAFLD may determine liver fibrosis progression in GD patients on stable ERT and may be a risk factor for long-term liver-related complications.Significant steatosis is highly prevalent in adult type 1 GD patients and is strongly associated with a worse metabolic profile, featuring metabolic dysfunction-associated fatty liver disease (MAFLD). MAFLD may determine liver fibrosis progression in GD patients on stable ERT and may be a risk factor for long-term liver-related complications.Laparoscopic sigmoidectomy is a well standardized procedure and offers excellent early and late results with low risk of recurrence and metastasis despite the significant risk of anastomotic leakage due to compromised blood supply through ligation of inferior mesenteric artery (IMA). Whether high or low IMA ligation should be performed remains controversial due to oncological reasons, vascular supply of the distal stump and lymph nodes harvested. Recently, Left Colic Artery (LCA) preservation with lymph node dissection of IMA root during laparoscopic surgery for early rectosigmoid cancer has been proposed to avoid leaks ensuring an adequate lymph node harvest [1].Traumatic reticuloperitonitis combined with embolic pneumonia and hepatitis is unusual signs of foreign body syndrome in cattle. A 4-year-old Holstein bull presented decreased appetite, dry cough, progressive weight loss, sternal recumbence and reluctance to stand and move. Laboratory tests revealed leucocytosis (18.4 × 103 /μl) accompanied by neutrophilia (10.48 × 103 /μl), and monocytosis (1.28 × 103 /μl), hyperglobulinaemia (6.3 g/dl), hypoalbuminaemia (1.5 g/dl), hyperfibrinogenaemia (10 g/L) and severe increase in gamma-glutamyl transferase activity (1,216 U/L). Reticular ultrasonographical examination showed a large amount of hyperechoic and hypoechoic content between the reticular serosa and the hepatic visceral surface. The main gross findings included fibrin deposition and adhesions between the reticulum, liver and diaphragm surfaces; a 4.0 mm in diameter transmural reticular perforation; a 12.0-cm diameter and scarce small randomly abscesses in the liver's parenchyma. The lungs presented multifocal areas of suppurative embolic foci (pulmonary abscesses), interstitial emphysema and multifocal fibrin deposition on the pleural surface. Ancillary diagnostic tests, such as ultrasonography and laboratory test, associated with clinical evaluation, may increase the accuracy of the correct diagnosis and avoid wasting time and money on untreatable cases. Dental ergonomics aim to improve the safety and efficiency of dentists, reducing possible occurrence of musculoskeletal disorders (MSDs). Factors affecting dental ergonomics include gender, tooth position, and use of equipment such as magnifying loupes. Since work habits are acquired early during undergraduate dental training, it is essential to assess the ergonomics of students at the preclinical training level. The present study aimed to assess the ergonomics of preclinical dental students in different clinical settings and their correlation to potential MSDs. Student posture was assessed during preclinical restorative training using the Dental Ergonomics Assessment rubrics visual scale. The variables tested were use of magnification, gender, and tooth position. Musculoskeletal (MS) pain was reported using a questionnaire. Results were analyzed statistically using Mann-Whitney U test and Wilcoxon t-test (P < 0.05). Spearman test was used to determine the correlation between posture and pain. Use of magnification and tooth position significantly affected student posture.