I. Single-isocenter dynamic conformal arc (SIDCA) therapy is atechnically efficient way of delivering stereotactic radiosurgery (SRS) to multiple metastases simultaneously. This study reports on the safety and feasibility of linear accelerator (LINAC) based SRS with SIDCA for patients with multiple brain metastases. All patients who received SRS with this technique between November 2017 and June 2019 within aprospective registry trial were included. The patients were irradiated with adedicated planning tool for multiple brain metastases using aLINAC with a5 mm multileaf collimator. Follow-up was performed every 3months, including clinical and radiological examination with cranial magnetic resonance imaging (MRI). These early data were analyzed using descriptive statistics and the Kaplan-Meier method. A total of 65patients with 254 lesions (range 2-12) were included in this analysis. Median beam-on time was 23 min. The median follow-up at the time of analysis was 13months (95% CI 11.1-14.9). Median overall survival and median intracranial progression-free survival was 15months (95% CI 7.7-22.3) and 7months (95% CI 3.9-10.0), respectively. Intracranial and local control after 1year was 64.6and 97.5%, respectively. During follow-up, CTCAE gradeI adverse effects (AE) were experienced by 29patients (44.6%; 18of them therapy related, 27.7%), CTCAE gradeIIAEs by four patients (6.2%; one of them therapy related, 1.5%), and CTCAE gradeIIIby three patients (4.6%; none of them therapy related). Two lesions (0.8%) in two patients (3.1%) were histopathologically proven to be radiation necrosis. Simultaneous SRS using SIDCA seems to be afeasible and safe treatment for patients with multiple brain metastases.Simultaneous SRS using SIDCA seems to be a feasible and safe treatment for patients with multiple brain metastases. Psychiatric hospitals or mental asylums grew across the world in the colonial era. Despite concerns over quality of care and human rights violations, these hospitals continue to provide the majority of mental health care in most low- and middle-income countries (LMICs). We sought to review the evidence of reform of mental hospitals and associated patient outcomes. We adopted an integrative review methodology by including experimental and non-experimental research. The review protocol was registered on PROSPERO (CRD42019130399). A range of databases and systematic hand searches were conducted by two independent reviewers. Research conducted between 1980 and May 2019, that focused on any aspect of reform in mental hospitals for adults (age 18 and upwards) with severe mental illness and published in English, were considered. 16 studies were included in the review. 12 studies met inclusion criteria, and four additional reports emerged from the hand search. Selleck QNZ covered-India, China, South Africa, Grenadaic hospitals. However, poor methodological quality and variation in approach and outcomes measured, make it challenging to extrapolate specific findings on process or outcomes of reform. Despite being integral service providers, psychiatric hospitals still do not adopt patient centric, recovery-oriented processes. Hence, there is an urgent need to generate robust evidence on psychiatric reform and its effect on patient outcomes.Tinea capitis is seen world-wide among children up to 12 years. The most severe type is Kerion Celsi with painful abscesses and lymphadenopathy. We report on an 11-year-old boy with Kerion Celsi, who was initially treated using antibiotics under the common misdiagnosis of a bacterial infection. Mycological investigations could identify Microsporum canis. The patient was treated orally with griseofulvin, which resulted in complete mycological remission after 8 weeks. Cicatrical alopecia, however, could not be prevented. Purulent infections of the scalp should lead to early mycological diagnostics in children.We report on three patients with inflammatory dermatoses as a result of a chronic inflammatory bowel disease (IBD). The diagnosis of IBD was based on the initial determination of the fecal calprotectin value. Although the patients did not report any intestinal complaints, the increased calprotectin value in the stool was the reason for further gastroenterological evaluation. #link# This article highlights the importance of determining the fecal calprotectin value as another parameter in the diagnosis of inflammatory dermatoses. Outdoor workers are occupationally exposed to significantly higher ultraviolet (UV) doses than the rest of the population. Recent data show adoubling of basal cell carcinoma (BCC) risk in outdoor workers with high occupational UV exposure. To examine the stability and robustness of BCC risk estimators. Sensitivity analyses to test model assumptions considering socioeconomic status, influence of matching procedure, gender and latency, regional differences (east/west), urban/rural cases/controls, and dual diagnoses (squamous cell carcinoma [SCC]/actinic keratoses gradeIII [AKIII]/Bowen disease [BD] and BCC) were performed. BCC risk was consistently higher for high occupationally UV-exposed individuals than for intermediate UV-exposed individuals, regardless of matching procedure, latency, regional differences (east/west), urban/rural recruitment of cases/controls, and dual diagnoses (SCC/AKIII/BD and BCC), sex, and socioeconomic status. The risk estimator for the association between exposure to solar UV radiation at work and the risk of developing BCC showed ahigh degree of stability and robustness for all variables investigated. The analyses support the recently published findings on the doubling of BCC risk in outdoor workers with high occupational UV exposure.The risk estimator for the association between exposure to solar UV radiation at work and the risk of developing BCC showed a high degree of stability and robustness for all variables investigated. The analyses support the recently published findings on the doubling of BCC risk in outdoor workers with high occupational UV exposure. In recent years, an increasing spectrum of systemic therapies has become available in the field of dermatology. Some of these drugs are used off-label, which for example can lead to problems with reimbursement. This article is therefore intended to provide an overview of the currently approved systemic therapies in dermatology and to point out further alternatives such as Compassionate Use and Early Access Programs. The search for approved drugs in Germany was conducted online in the database for drugs of the Federal Institute for Drugs and Medical Devices. In addition, acomparison was made with the information provided from the Rote Liste. For atotal of 50dermatologically relevant diseases, the respective approved system therapies are presented in tabular form. It can be stated that the enormous developments over the last few years and the increasingly good evidence offer in many cases very promising systemic treatment concepts despite the frequent lack of clinical studies in the field of dermatology.