marchroot6
marchroot6
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Aba South, Gombe, Nigeria
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Obesity is associated with the gut microbiota and decreased micronutrient status. Bariatric surgery is a recommended therapy for obesity. It can positively affect the composition of the gut bacteria but also disrupt absorption of nutrients. Low levels of micronutrients can affect metabolic processes, like glycolysis, TCA cycle, and oxidative phosphorylation, that are associated with the immune system also known as immunometabolism. MEDLINE, PUBMED, and Google Scholar were searched. Articles involving gut microbiome, micronutrient deficiency, gut-targeted therapies, transcriptome analysis, micronutrient supplementation, and bariatric surgery were included. Studies show that micronutrients play a pivotal role in the intestinal immune system and regulating immunometabolism. Research demonstrates that gut-targeting therapies may improve the microbiome health for bariatric surgery populations. There is limited research that examines the role of micronutrients in modulating the gut microbiota among the bariatric surgery population. Investigations are needed to understand the influence that micronutrient deficiencies have on the gut, particularly immunometabolism. Nutritional transcriptomics shows great potential in providing this type of analysis to develop gut-modulating therapies as well as more personalized nutrition recommendations for bariatric surgery patients.Investigations are needed to understand the influence that micronutrient deficiencies have on the gut, particularly immunometabolism. Nutritional transcriptomics shows great potential in providing this type of analysis to develop gut-modulating therapies as well as more personalized nutrition recommendations for bariatric surgery patients.Many studies investigated variation in the frequency of extrapair paternity (EPP) among individuals. However, our understanding of within-individual variation in EPP remains limited. Here, we comprehensively investigate variation in EPP at the within-individual level in a population of blue tits (Cyanistes caeruleus). Our study is based on parentage data comprising >10 000 genotyped offspring across 11 breeding seasons. First, we examined the repeatability of the occurrence of EPP, the number of extrapair offspring, the number of extrapair partners, and the occurrence of paternity loss using data from males and females that bred in multiple years. Second, we tested whether within-individual changes in EPP between breeding seasons relate to between-year changes in the local social environment. Repeatabilities were generally low but significant for the occurrence and number of extrapair young in females and for whether a male sired extrapair young or not. We found no evidence that the presence of the former social partner or changes in the proportion of familiar individuals or in phenotypic traits of the neighbors influenced changes in levels of EPP in females. However, in adult males, a decrease in the average body size of male neighbors was associated with higher extrapair siring success. If confirmed, this result suggests that the competitive ability of a male relative to its neighbors influences his extrapair mating success. We suggest that alternative hypotheses, including the idea that within-individual changes in EPP are due to "chance events" rather than changes in an individual's social breeding environment, deserve more consideration.We present a model-independent method to estimate the effects of short-distance constraints (SDCs) on the hadronic light-by-light contribution to the muon anomalous magnetic moment a μ HLbL . The relevant loop integral is evaluated using multi-parameter families of interpolation functions, which satisfy by construction all constraints derived from general principles and smoothly connect the low-energy region with those where either two or all three independent photon virtualities become large. In agreement with other recent model-based analyses, we find that the SDCs and thus the infinite towers of heavy intermediate states that are responsible for saturating them have a rather small effect on a μ HLbL . Taking as input the known ground-state pseudoscalar pole contributions, we obtain that the longitudinal SDCs increase a μ HLbL by ( 9.1 ± 5.0 ) × 10 - 11 , where the isovector channel is responsible for ( 2.6 ± 1.5 ) × 10 - 11 . More precise estimates can be obtained with our method as soon as further accurate, model-independent information about important low-energy contributions from hadronic states with masses up to 1-2 GeV become available.We investigate the possibility of indirectly constraining the B + → K + τ + τ - decay rate using precise data on the B + → K + μ + μ - dimuon spectrum. To this end, we estimate the distortion of the spectrum induced by the B + → K + τ + τ - → K + μ + μ - re-scattering process, and propose a method to simultaneously constrain this (non-standard) contribution and the long-distance effects associated to hadronic intermediate states. The latter are constrained using the analytic properties of the amplitude combined with data and perturbative calculations. Finally, we estimate the sensitivity expected at the LHCb experiment with present and future datasets. We find that constraints on the branching fraction of O ( 10 - 3 ) , competitive with current direct bounds, can be achieved with the current dataset, while bounds of O ( 10 - 4 ) could be obtained with the LHCb upgrade-II luminosity.Self-sovereign identity (SSI) solutions implemented on the basis of blockchain technology are seen as alternatives to existing digital identification systems, or even as a foundation of standards for the new global infrastructures for identity management systems. ARV-110 It is argued that 'self-sovereignty' in this context can be understood as the concept of individual control over identity relevant private data, capacity to choose where such data is stored, and the ability to provide it to those who need to validate it. It is also argued that while it might be appealing to operationalise the concept of 'self-sovereignty' in a narrow technical sense, depreciation of moral semantics obscures key challenges and long-term repercussions. Closer attention to the normative substance of the 'sovereignty' concept helps to highlight a range of ethical issues pertaining to the changing nature of human identity in the context of ubiquitous private data collection.

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