Our results indicated that spinal cord DC scaffolds have good histocompatibility and spatial structure, and can promote the proliferation of adherent OECs. In animal experiments, scaffolds carrying OECs have better axon regeneration promoting protein expression than the SCI model, and improve the proliferation and distribution of astrocytes at the site of injury. These results proved that the spinal cord DC scaffold with OECs can promote axon regeneration at the site of injury, providing a new basis for clinical application. This study aimed to further elucidate correlated weight changes in parent-child dyads enrolled in family-based treatment (FBT) by modeling the interdependence of weight changes during treatment. Parent-child dyads (n = 172) with overweight/obesity (child mean zBMI = 2.16 ± 0.39; parent mean BMI = 37.9 ± 9.4 kg/m ) completed 4 months of FBT and were randomized to one of three 8-month maintenance interventions (Social Facilitation Maintenance [SFM]-high dose, SFM-low dose or control). Weight/height was measured at 0, 4 and 12 months. Structural equation models simultaneously estimated the effect that an individual had on their own (actor effect) and on one another's (partner effect) weight-status across time using the actor-partner interdependence model. Actor paths were significant over time for parent and child. Partner paths were significant for child zBMI predicting parent BMI at 4 and 12 months. Maintenance condition moderated actor/partner paths in the model. Child weight change may motivate parents to make environmental and behavioural changes that impact their own weight. ClinicalTrials.gov Identifier NCT00759746.ClinicalTrials.gov Identifier NCT00759746.Porous metal complexes enable single-crystal X-ray crystallographic observation of included guests or reaction intermediates through simple soaking with the guests/substrates. Previous studies on this technique have often encountered difficulties in the observation of chiral structures because the host frameworks had no chirality. We synthesized a new metal-peptide porous complex through a folding-and-assembly strategy and utilized the chiral pore for trapping chiral guests. Chiral alcohols and ketones were successfully included within the pore. Crystallographic analyses clearly revealed not only their chemical structures but also chiral transformation events within the pore such as fixed conformations or an unstable hemiacetal formation.This paper considers samples of independent writing highlighting the integral role of phonology, orthography and morphology in spelling development for children from 5-6 years to 7-8 years (3 years of formal schooling). It also introduces an approach to monitoring spelling development by considering the sources of knowledge that are evident in children's attempts to spell when writing independently. Synthetic phonics can be a powerful and effective strategy for both reading and spelling; however when the development of a synthetic phonics strategy fails to take account of the importance of compatibility with orthographic and morphemic knowledge its predominant use can lead to long term spelling difficulties for children who cannot acquire this knowledge from implicit learning when reading. Furthermore, this paper proposes that there may be an optimum period for ensuring the interaction between phonemic, orthographic and morphemic knowledge (5-6 years to 7-8 years; 3 years of formal schooling) during which time significant gains can be made for all children. This optimum period is particularly important for children who are at risk of long-term spelling difficulties because they spell by sounds alone as a result of insensitivity to orthographic and ortho-morphemic patterns. Although kidney impairments have been reported following immune checkpoint inhibitors (ICIs) in clinical studies, there are few pharmacoepidemiology studies to compare the occurrences, clinical features, and prognosis of renal adverse effects. Disproportionality and Bayesian analysis were used in data mining to screen the suspected renal adverse effects after the administration of different ICIs, based on FDA's Adverse Event Reporting System (FAERS) from January 2004 to September 2019. The time to onset, fatality and hospitalization rates of renal adverse effects were also investigated. We identified 1444 reports of renal adverse effects. Affected patients tended to be older than 65years (52.7%). Renal effects were most commonly reported in nivolumab monotherapy (33.24%). Atezolizumab appeared the strongest association among six ICI monotherapies, based on the highest reporting odds ratio (ROR=144.38, two-sided 95% CI=123.08 -169.37), proportional reporting ratio (PRR=139.13, χ =21425.38), and empiricern should be paid for patients with a tendency for kidney impairments, such as old age.Based on the FAERS database, we profiled renal adverse effects after various ICIs with real-world data in occurrences, clinical characteristics, and prognosis. Zelavespib Renal effects should be tightly monitored, especially within the first several months after ICIs administration. Particular concern should be paid for patients with a tendency for kidney impairments, such as old age.Single-atom catalysts (SACs) have emerged as promising materials in heterogeneous catalysis. Previous studies reported controversial results about the relative level in activity for SACs and nanoparticles (NPs). These works have focused on the effect of metal atom arrangement, without considering the oxidation state of the SACs. Here, we immobilized Pt single atoms on defective ceria and controlled the oxidation state of Pt SACs, from highly oxidized (Pt0 16.6 at %) to highly metallic states (Pt0 83.8 at %). The Pt SACs with controlled oxidation states were then employed for oxidation of CO, CH4 , or NO, and their activities compared with those of Pt NPs. The highly oxidized Pt SACs presented poorer activities than Pt NPs, whereas metallic Pt SACs showed higher activities. The Pt SAC reduced at 300 °C showed the highest activity for all the oxidations. The Pt SACs with controlled oxidation states revealed a crucial missing link between activity and SACs.