INTRODUCTION Cutaneous adverse events (AE) are the most prevalent toxicity under checkpoint-inhibitors in clinical trials. In "real-life" conditions of use, skin toxicities under anti-PD-1 have not been described to date in a large cohort. The objective of this study was to determine the clinical features of skin toxicities in patients with advanced melanoma receiving anti-PD-1 therapy under "real-life"-conditions of use. A1874 purchase Secondary objectives were to evaluate the characteristics of patients with skin toxicities and to analyze associated extra-cutaneous toxicities, progression-free-survival (PFS) and overall-survival (OS). PATIENTS AND METHODS Advanced melanoma patients treated with nivolumab or pembrolizumab between August 2014 and October 2017 were included. Patients lost to follow-up or receiving anti-PD-1 as part of a clinical trial were excluded. RESULTS One-hundred-and-eighty-nine patients with metastatic melanoma (with 109 men (57.7%) were included. Cutaneous AE occurred in 39 patients (20.6%). The three most prevalent cutaneous AE were skin eruption (macular-papular or eczematous), (n=18, 9.5%), vitiligo (n=16; 8.5%) and isolated pruritus (n=5, 2.6%). Grade 3-4 skin toxicity was diagnosed in 5 patients (2.6%). Atopy (28.2% vs. 12.0%; p=0.024), hypereosinophilia (20.5% vs. 8.7%; p=0.046), thyroiditis (17.9% vs. 4.7%; p=0.011) and renal toxicity (15.4% vs. 4%; p=0.019) were significantly associated with cutaneous AE. Patients with skin eruption (log-rank=0.001), vitiligo (log-rank=0.001) and any type of cutaneous AE (Log-rank less then 0.001) had a better overall survival. CONCLUSIONS Cutaneous AEs are frequent, often manageable toxicity and were a predictor of tumor response in melanoma patients under anti-PD-1 therapy in this cohort. This article is protected by copyright. All rights reserved.Novel lithium-lanthanide (lanthanide shortened as Ln cerium and praseodymium) bimetallic coordination polymers of the formula C10H2LnLiO8(Ln Ce named as CeLipmaand Pr named as PrLipma) and C10H3CeO8(named as Cepma) were prepared by a simplehydrothermal method. The 3 compounds were characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), single crystal X-ray diffraction (SXRD), scanning electron microscopy (SEM), transmission electron microscope (TEM) andX-ray photoelectron spectroscopy(XPS). The results of the structural refinement show that they belong to triclinic symmetry and P-1 space group with cerium (or praseodymium) and lithium cations forming coordination bonds to oxygen atoms from different pyromellitic acid molecules and constructing into three-dimensional (3D) structures, it is interesting of the frameworks to exclude any coordination water and lattice water. As an electrode material for lithium ion batteries, CeLipma exhibits a maximum capacity of 800.5 mAh/g and a retention of 91.4% after 50 cycles at a current density of 100 mA/g. The favorable electrochemical properties of the lanthanide coordination polymers show potential application prospect in the field of electrode materials. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.BACKGROUND Mucosal melanoma is a rare malignancy which represents approximately 1% of all melanomas. It is shown that mucosal melanomas have a different biology and less favorable prognosis than its cutaneous counterpart. OBJECTIVES Predictive and prognostic factors of survival for mucosal melanoma have not yet been elucidated. The aim of this study is to investigate risk factors affecting the course of mucosal melanoma patients followed in our clinic. METHODS One hundred sixty one patients with mucosal melanoma prospectively documented in the German Central Malignant Melanoma Registry(CMMR) were included in this study. Gender, age, localization, stage at first medical examination, tumor thickness and mutational status were documented. The American Joint Committee on Cancer(AJCC), 7th edition was used to define tumor stage. Kaplan-Meier survival curves were evaluated compared with the log-rank test. Multivariate Cox proportional hazard models were used to identify significant independent prognostic factors. Rystem is applicable for mucosal melanoma. This article is protected by copyright. All rights reserved.BACKGROUND The common inflammatory scalp disorders share similar clinical manifestations, and patient work up require invasive, undesirable diagnostic procedures like biopsy to ensure correct diagnosis. Optical coherence tomography (OCT) is a non-invasive high-resolution imaging modality that has found a valuable tool to assist in the diagnose and evaluation of different skin diseases. OBJECTIVES To describe the structural and vascular dynamic OCT (D-OCT) findings of inflammatory scalp disorders including scalp psoriasis, seborrhoeic dermatitis and contact dermatitis and to compare trichoscopy and OCT features. METHODS Subjects with diagnosis of seborrhoeic dermatitis, psoriasis or contact dermatitis were enrolled in this study. OCT scans were taken on involved scalp, and the same scalp regions were evaluated by trichoscopy and compared with healthy scalp. RESULTS A total of fourteen subjects (two healthy controls, four seborrhoeic dermatitis, five psoriasis and three contact dermatitis) participated. D-OCT imaging of vascular pattern in healthy scalp and the inflammatory scalp disorders were described. D-OCT images could enhance the clinician's ability to distinguish psoriasis from seborrhoeic dermatitis by objectively detect and assess red loop density. In scalp contact dermatitis, the vessels of the deep plexus were more dilated and fewer in number than those found in seborrhoeic dermatitis. CONCLUSION Dynamic OCT provides information that more clearly elucidates changes at the level of the superficial and deep plexuses without invasively interfering with superficial structures. In the context of inflammatory scalp disorders, this is useful to discern disorders with overlapping symptoms and minimize the use of invasive biopsies to diagnose. © 2020 European Academy of Dermatology and Venereology.Bone marrow adipose tissue (BMAT) resides within the bone marrow microenvironment where its function remains poorly understood. BMAT is elevated in anorexia nervosa, a disease model of chronic starvation, despite depletion of other fat depots. In addition to BMAT, the marrow microenvironment also consists of osteoblast and hematopoietic progenitors. BMAT is inversely associated with bone mineral density (BMD) in multiple populations including women with anorexia nervosa, and regulates hematopoiesis in animal models. We hypothesized that BMAT would be associated with circulating populations of hematopoietic cells (red and white blood cells) in humans and performed a post-hoc analysis of two studies - a cross-sectional study and longitudinal study - to investigate this hypothesis. We studied 89 premenopausal women cross-sectionally (median age [interquartile range] 27 [24.5, 31.7] years), including 35 with anorexia nervosa. We investigated associations between red blood cell (RBC) and white blood cell (WBC) counts and BMAT assessed by 1 H- magnetic resonance spectroscopy, BMD assessed by DXA, and bone microarchitecture assessed by HR-pQCT.