Mechanistically, we found that STAM2 knockdown effectively decreased the expressions of MMP2 and MMP9 and the phosphorylation levels of JAK2 and STAT3. Taken together, this study revealed that STAM2 knockdown could suppress malignant process by targeting the JAK2/STAT3 signaling pathway in GC.Life course epidemiology is useful for describing and analyzing complex etiological mechanisms for disease development, but existing statistical methods are essentially confirmatory, as they rely on a priori model specification. This limits the scope of causal inquiries that can be made, since these methods are mostly suited to examine well-known hypotheses that do not question our established view of health, which may lead to confirmation bias. We propose an exploratory alternative. Instead of specifyinga life course model prior to data analysis, our method infers the life course model directly from the data. Our proposed method extends the well-known PC algorithm (named after its authors, Peter and Clark) for causal discovery and it facilitates including temporal information for inferring a model from observational data. The extended algorithm is called temporal PC. The obtained life course model can afterwards be perused for interesting causal hypotheses. Our method complements classical confirmatory methods, and guides researchers in expanding their models in new directions. We showcase the method on a dataset encompassing almost 3000 Danish men followed from birth until age 65. Using this dataset, we infer life course models for the role of socio-economic and health-related factors on development of depression. To improve the teaching effect of orbital anatomy course for students majoring in stomatology. Based on a retrospective analysis of average score of orbital anatomy course for previous dental and medical students, and the problems existing in teaching effect, orbital anatomy and orbital imaging course were designed and carried out in dental students. The course combined imaging with orbital anatomy, and included clinical examples. Medical students were set as control. Examination was carried out after the end of the whole course, and the professional knowledge of orbital anatomy of two groups was compared. A self-designed questionnaire was designed to evaluate the teaching effect of orbital anatomy and orbital imaging courses for dental students and residents over 1 year after graduation. SPSS 22 software package was used for Statistical analysis. The previous average score of dental students was 7.50, and the average score of medical students was 8.67. There was significant difference between the two gve thinking, narrowed students to master the knowledge of orbital anatomy, closed the gap of teaching effect between dental and clinical medicine, and laid the foundation to develop dental professional work in the future.Orbital anatomy and orbital imaging course were designed for dental students as supplementary teaching programme. It successfully inspired students' interest in learning, cultivated the students' overall and comprehensive thinking, narrowed students to master the knowledge of orbital anatomy, closed the gap of teaching effect between dental and clinical medicine, and laid the foundation to develop dental professional work in the future. To evaluate the association between periodontitis and Alzheimer's disease. Databases of PubMed, Embase, CNKI, VIP and WanFang databases were searched for the relevant observational studies focusing on the association between periodontitis and Alzheimer's disease. The deadline was January 2019. Data quality evaluation and extraction were independently conducted by two authors. Meta analysis was performed using RevMan 5.2 software. Four case-control, five cross-sectional and two cohort studies were included. One cohort study and four case-control studies treated periodontitis as the exposure factor, all five cross-sectional studies and the other cohort study treated Alzheimer's disease as the exposure factor. The results of meta analysis showed that patients with periodontitis had a higher risk of Alzheimer's disease (RR=1.22, 95%CI 1.13-1.33, P<0.00001), and the risk was more higher in patients with severe periodontitis(RR=1.54, 95%CI1.05-2.26, P=0.03<0.05); but there was no significant difference ver, the number of existing studies is limited and more clinical evidences are needed to support the correlation between these two diseases.The current evidence indicates that periodontitis is associated with Alzheimer's disease and patients with periodontitis (especially severe periodontitis) probably have a higher risk of developing Alzheimer's disease, and patients with Alzheimer's disease tend to have poorer periodontal health. However, the number of existing studies is limited and more clinical evidences are needed to support the correlation between these two diseases. To evaluate the morphology and position of condyle and fossa and joint space of adolescent temporomandibular joint with Class Ⅱ subdivision malocclusion, in order to provide a reference for diagnosis before treatment. The study sample consisted of 30 adolescent patients with Class Ⅱ subdivision malocclusions(9 males, 21 females, mean age 12.5 years) as the experimental group and 30 adolescent patients with Class Ⅰ malocclusions (11 males, 19 females, mean age 12 years) as the control group treated from June 2018 to December 2019 in Suzhou Stomatological Hospital. The long axis of condyle, short axis of condyle, the distance from the outer pole of condyle to sagittal midline, horizontal angle of condyle, Joint space(medial, inner, outer, anterior, superior, posterior), vertical height of condyle, width of joint fossa, depth of joint fossa, angle of posterior wall of the articular tubercle and vertical distance of bilateral condyle to horizontal line were measured on cone-beam CT(CBCT) images and analyzed wsubdivision malocclusions and Class Ⅰ malocclusion patients. More attention should be paid to the temporomandibular joint in initial clinical examination and clinical orthodontic treatment. To explore the effects of different orthodontic techniques on the changes of alveolar bone density, height and gingival crevicular fluid (GCF) bleeding in upper incisor in patients with periodontitis. Twenty-three patients with moderate periodontitis who underwent orthodontic treatment from January 2016 to December 2019 in the Department of Stomatology of Jiangxi Pingxiang People's Hospital were divided into experimentalexperimental group(n=12) and control group(n=11). Patients in the experimental group were treated with bracket-less invisible appliance, while patients in the control group were treated with conventional lip-side fixed appliance. Selleckchem Setanaxib Changes of gingival crevicular hemorrhage index, probing depth, alveolar bone height and bone density in the incisor area were compared between the two groups before and after treatment. Statistical analysis was performed on data using SPSS 22.0 software package. After treatment, the bone mineral density of the upper incisor alveolar crest (L1) of the two groups decreased, and the rate of decrease in the experimental group was significantly less than that in the control group (P<0.