In conclusion, this study shows that gonadal infertility is associated with not only changes in histological structure and hormone secretion but also changes in metabolism, immunity, and signal transduction networks in the liver. These results provide valuable information concerning the mechanism underlying infertility in fish.Recovery from axonal injury is extremely difficult, especially for adult neurons. Here, we demonstrate that the activation of G-protein coupled receptor 110 (GPR110, ADGRF1) is a mechanism to stimulate axon growth after injury. N-docosahexaenoylethanolamine (synaptamide), an endogenous ligand of GPR110 that promotes neurite outgrowth and synaptogenesis in developing neurons, and a synthetic GPR110 ligand stimulated neurite growth in axotomized cortical neurons and in retinal explant cultures. Intravitreal injection of GPR110 ligands following optic nerve crush injury promoted axon extension in adult wild-type, but not in gpr110 knockout, mice. In vitro axotomy or in vivo optic nerve injury rapidly induced the neuronal expression of gpr110. Activating the developmental mechanism of neurite outgrowth by specifically targeting GPR110 that is upregulated upon injury may provide a novel strategy for stimulating axon growth after nerve injury in adults.High-strength screws represent one of the main joining or fastening components which are commonly used in the process of installation of frame constructions for information boards or signposts, relating to the traffic roads. The control of the production process may not always be a sufficient method for ensuring road safety. The backward investigation and control of the screw material processing seems to be the one of the most important procedures when there is the occurrence of any failure during the operation of the screw. This paper is mainly focused on the analysis of the failure of the high-strength screw of 10.9 grade with M diameter of 27 × 3 and a shank length of 64 mm. The mentioned and investigated screw was used as a fastener in a highway frame construction. In the paper, there is mainly the analysis of the material for a broken screw in terms of the material micropurity, the material microstructure, the surface treatment as well as chemical composition. The evaluation was based on investigation bycomponent. Combined with the measurement of the HV1 (Vickers hardness at a load of 1 kg) from the edge to the central area of the screw, the analysis revealed the significant drawbacks in the heat treatment of the high-strength screw.In this paper, we propose a method of identifying human motions, such as standing, walking, running, and crawling, using a millimeter wave radar sensor. In our method, two signal processing is performed in parallel to identify the human motions. First, the moment at which a person's motion changes is determined based on the statistical characteristics of the radar signal. Second, a deep learning-based classification algorithm is applied to determine what actions a person is taking. In each of the two signal processing, radar spectrograms containing the characteristics of the distance change over time are used as input. Finally, we evaluate the performance of the proposed method with radar sensor data acquired in an indoor environment. The proposed method can find the moment when the motion changes with an error rate of 3%, and also can classify the action that a person is taking with more than 95% accuracy.The presented research aimed to identify the impacts of the second wave of the coronavirus disease 2019 (COVID-19) pandemic on respondents' mental health state and identify variables related to the respondents' symptoms of anxiety and depression; 618 subjects participated in the research. A specially prepared survey and Polish adaptations of the following methods were used Hospital Anxiety and Depression Scale (HADS), Perceived Stress Scale (PSS 10), MINI-COPE Questionnaire (Brief COPE Inventory), Alcohol Use Disorder Identification Test (AUDIT), Scale of Death Anxiety (SDA), The Fear of COVID-19 Scale (FCV-19S). Over 24% of the respondents reported having experienced suicidal thoughts since the start of the pandemic. Almost 16% drank alcohol in a risky or harmful way. The average value of perceived stress indicated its high and very high intensity. Over 20% had symptoms of anxiety disorders, and almost 19% had anxiety and depression symptoms. It means that almost 40% of the respondents probably have mental disorders. More women, younger people, and those with disorders prior to the onset of the pandemic were among those who manifested these disorders. They also used passive and avoidance stress coping strategies more frequently. In conclusion, the second wave of the pandemic negatively affected the mental health of the respondents. A high percentage of the respondents manifested anxiety and anxiety-depressive disorders and declared having of suicidal thoughts.In the actual mining scenario, copper bioleaching, mainly raw mined material known as run-of-mine (ROM) copper bioleaching, is the best alternative for the treatment of marginal resources that are not currently considered part of the profitable reserves because of the cost associated with leading technologies in copper extraction. It is foreseen that bioleaching will play a complementary role in either concentration-as it does in Minera Escondida Ltd. (MEL)-or chloride main leaching plants. In that way, it will be possible to maximize mines with installed solvent-extraction and electrowinning capacities that have not been operative since the depletion of their oxide ores. One of the main obstacles for widening bioleaching technology applications is the lack of knowledge about the key events and the attributes of the technology's critical events at the industrial level and mainly in ROM copper bioleaching industrial operations. It is relevant to assess the bed environment where the bacteria-mineral interactiontures, column-leaching tests, and the industrial bioleaching heap was defined. learn more We presented the results obtained from the industrial validation of the marker genes selected for assessing CO2 and N2 availability, osmotic stress response, as well as ferrous iron and sulfur oxidation activity in the bioleaching heap process of MEL. We demonstrated that molecular markers are useful for assessing limiting factors like nutrients and air supply, and the impact of the quality of recycled solutions. We also learned about the attributes of variables like CO2, ammonium, and sulfate levels that affect the industrial ROM-scale operation.