The summarized scientific value of previous approaches and structural features of antimalarials related to the activity are highlighted that will be helpful for the development of next-generation antimalarials.The photo-ammonification process plays a crucial role in the transformation of dissolved organic nitrogen (DON) to dissolved inorganic nitrogen (DIN). However, previous studies have primarily focused on DON biotransformation than on abiotic processes. This study investigated the photo-ammonification process of nine model low molecular weight (LMW) DON molecules (e.g., amino acids, nucleotides, and urea) under the influence of different light sources. The results showed that photo-ammonification of model DON was mainly induced by UV light, while negligible contribution by visible light was found. Depending on their molecular structures, amino acids yielded different ammonia amounts, whereas negligible photo-ammonification was observed for nucleotides and urea. As for the reactive species, OH promoted ammonia yields of all the model amino acids; 3CDOM⁎ contributed to the photo-ammonification of six amino acids; 1O2 only had a positive impact on ammonification of tryptophan, histidine, and tyrosine; and CO3- accelerated ammonia generation from histidine and methionine. In natural water samples, tryptophan, tyrosine, histidine, and methionine generated significant ammonia. OH and 1O2 were speculated as the contributing reactive species based on kinetic studies as well as significant fluorescent humic-like and tyrosine-like substances degradation in irradiated samples compared to the raw samples characterized by the EEM-PARAFAC analysis. The negative linear correlations between photo-ammonification rates and the ELUMO-EHOMO of the amino acids emphasized the importance of the role of the molecular structure. Overall, these results revealed the LMW DON photo-ammonification mechanism in sunlit surface waters and highlighted its significance in the nitrogen biogeochemical cycle as well as water quality management.Soil salinization poses a great threat to the natural ecosystem and interferes with the structure and function of the biological community, resulting in different vegetation distributions. However, little attention is paid to the changes in microbial community in different wetland types with the same vegetation. In this study, the Yellow River Delta was used as a model because of its typical and extensive distribution of Phragmites australis-dominated saltwater and freshwater wetlands. We investigated the differences in the structure and function of bacterial communities, as well as their relationships with soil properties in coastal (Zone A) and riparian (Zone B) wetlands. Results showed higher salinity and pH in Zone A than Zone B (p less then 0.05), whereas TN (p less then 0.05) and SOM were lower than those in Zone B. Significant differences existed in microbial community composition between Zones A and B. The nitrifying-bacteria Nitrospira and norank_f_Nitrosomonadaceae had high abundance in Zones A l-community structure and function in Phragmites australis-dominated saltwater and freshwater wetlands.Shrinkage of plateau lakes under climate strength has drawn growing attention. Because of its intricate implication to hydro-meteorological condition and climate system, stable isotopes in precipitation (e.g. δ2Hp and δ18Op) provide us a powerful tool to understand the climate-hydrologic dynamics in shrinking lakes. Zeldox However, how the regional atmospheric circulation, moisture sources and local fractionation processes drive isotopic variability from temporal to spatial scale has rarely been reported for remote plateau lakes. Hence, we collected a total of 98 rainfall samples at the south and the north shores of Chenghai lake, Yunnan-Guizhou Plateau to study the potential driving forces of precipitation isotope variability during the wet season of 2019. Based on backward trajectories of air masses obtained from HYSPLIT model, 68% of moisture came from δ18O depleted ocean (Indian Ocean, Bay of Bengal, South China Sea and Pacific Ocean), and the rainout process promoted the isotopic depletion when moisture arrived at the study basin. Evapotranspiration increased the heavy isotope ratios in precipitation originated from continents (northern China inland and western continents). The temporal dynamics of δ18Op and δ2Hp were in phase with the convection activities intensity underlined the influence from large-scale atmospheric circulation. Local meteorological factors played a secondary role in isotope variability. Precipitation amount-effect strongly affected isotope ratios while mild anti-temperature effect was observed at daily scale. Interestingly, the rainfall isotope ratios showed different mechanisms in govern at lake south shore and north shore, with a distance of 19 km in between. This south-to-north difference can be explained by either lower 1.03% sub-evaporation in the south shore or 7% of recycled moisture contributing to precipitation in the north shore. Our findings discover the driving forces for δ18Op variation and provide solid interpretations for hydro-climate change in Southwest China.Current models for flu-like epidemics insufficiently explain multi-cycle seasonality. Meteorological factors alone, including the associated behavior, do not predict seasonality, given substantial climate differences between countries that are subject to flu-like epidemics or COVID-19. Pollen is documented to be allergenic, it plays a role in immuno-activation and defense against respiratory viruses, and seems to create a bio-aerosol that lowers the reproduction number of flu-like viruses. Therefore, we hypothesize that pollen may explain the seasonality of flu-like epidemics, including COVID-19, in combination with meteorological variables. We have tested the Pollen-Flu Seasonality Theory for 2016-2020 flu-like seasons, including COVID-19, in the Netherlands, with its 17.4 million inhabitants. We combined changes in flu-like incidence per 100 K/Dutch residents (code ILI) with pollen concentrations and meteorological data. Finally, a predictive model was tested using pollen and meteorological threshold values, inversely correlated to flu-like incidence.