Therefore with the current data, no scoring system could be identified as best. An objective measure of the extent of disease can be of great clinical use for identifying ovarian cancer patients for which a complete (or optimal) CRS is achievable, however due to local differences in treatment strategies and surgical policy a widely adopted objective scoring system with a standard cut-off value is not feasible. Nevertheless, objective scoring systems can play an important role to guide treatment decisions. Distant recurrence, especially liver metastases, occurs in one-third of rectal cancer patients initially treated with curative therapy and is still an unsolved problem. The identification of patients at risk is crucial for enabling individualized treatment. All patients undergoing curative resection for histologically confirmed rectal cancer after neoadjuvant radiochemotherapy between January 2001 and December 2015 were included. Sections were stained for Ki67, CD44, apoptosis and CD133. Patients were categorized based on whether they were found to have (CD44 /Ki67 ) or not have (CD44 /Ki67 ) still proliferating tumor cells. 218 patients who underwent R0 resection for stage I-III rectal cancer were selected. In 37 (17%) of these patients, CD44 /Ki67 tumor cells were found. In multivariable Cox regression analysis, patients with CD44 /Ki67 cells had significantly impaired overall (hazard ratio (HR) 3.84, 95% CI 1.77-8.31, p=0.001) and relative survival (HR 3.44, 95% CI 1.46-8.09). The previous results were confirmed after propensity-score matching. In mediation-analysis, the presence of CD44 /Ki67 cells was associated with a substantial direct effect on overall (HR 1.92, 95% CI 1.09-9.28) and relative survival (HR 1.63, 95% CI 1.31-6.38). The presence of still proliferating CD44 /Ki67 tumor cells after neoadjuvant radiochemotherapy was associated with impaired oncological long-term outcomes. Characterization of these cells should be performed.The presence of still proliferating CD44+/Ki67+ tumor cells after neoadjuvant radiochemotherapy was associated with impaired oncological long-term outcomes. Characterization of these cells should be performed. Depth of invasion (DOI) has been incorporated into oral cancer staging. Increasing DOI is known to be associated with an increased propensity to neck metastasis and adverse tumor factors and hence may not be an independent prognosticator but a surrogate for a biologically aggressive tumor. 570 patients, median follow up 79.01 months from a previously reported randomized trial (NCT00193765) designed to establish appropriate neck treatment [elective neck dissection (END) vs therapeutic neck dissection (TND)] in clinically node-negative early oral cancers were restaged (nT) according to AJCC TNM 8th edition. Overall survival (OS) was estimated for the entire cohort, END, and TND arms. Multivariate analysis performed for stratification and prognostic factors, and interaction term between revised T-stage and neck treatment, for tumours with DOI≤10mm. Presence of adverse factors was compared between nT3 (DOI>10mm) and those with DOI≤10mm. Stage migration occurred in 44.38% of patients. 5-Year OS was nT1-79%, nT2-69.4% and nT3-53.8%, (p<0.001). In TND arm 5-year OS was nT1-81.1% versus nT2-65%,p=0.004, while that in END arm was nT1 -76.9% versus nT2 -73.7%,p=0.73. There was a significant interaction between T stage and neck treatment (p=0.03). T3 tumors (>10mm) were associated with a higher proportion of adverse factors (occult nodal metastasis, p=0.035; LVE/PNI, p=0.001). Elective neck treatment negates the prognostic impact of DOI for early oral cancers (T1/T2 DOI≤10mm). T3 tumors with DOI>10mm have a higher association with other adverse risk factors resulting in poorer outcomes in spite of elective neck dissection.10 mm have a higher association with other adverse risk factors resulting in poorer outcomes in spite of elective neck dissection. Observational studies have suggested that plasma lipids contribute substantially to cardiovascular disease, but "cholesterol paradox" in atrial fibrillation (AF) remains. We sought to investigate the causal effects of lipid profiles on the risk of AF. Two-sample Mendelian randomization (MR) framework was implemented to examine the causality of association. Summary estimations of genetic variants associated with low density lipoprotein (LDL)-cholesterol, high density lipoprotein (HDL)-cholesterol, total cholesterol, triglycerides, lipoprotein-a [Lp(a)], apolipoprotein A1 (ApoA 1), and apolipoprotein B (ApoB) were 81, 99, 96, 61, 30, 10, and 23 single nucleotide polymorphisms, respectively. Genetic association with AF were retrieved from a genome-wide association study that included 1,030,836 individuals. The complications for AF were predefined as cardioembolic stroke (CES) and heart failure (HF). In the multivariable MR, the odds ratios for AF per standard deviation (SD) increase were 1.030 (95% confidence interval (CI) 0.979-1.083; P=0.257) for LDL-cholesterol, 0.986 (95% CI 0.931-1.044; P=0.622) for HDL-cholesterol, 0.965 (95% CI 0.896-1.041; P=0.359) for triglycerides, 1.001 (95% CI 1.000-1.003; P=0.023) for Lp(a), 1.017 (95% CI 0.966-1.070; P=0.518) for ApoA1, and 1.002 (95% CI 0.963-1.043; P=0.923) for ApoB. There was no evidence that other lipid components were causally associated with AF, CES, or HF, other than for a marginal association between triglycerides and HF. This MR study provides robust evidence that high Lp(a) increases the risk of AF, suggesting that interventions targeting Lp(a) may contribute to the primary prevention of AF.This MR study provides robust evidence that high Lp(a) increases the risk of AF, suggesting that interventions targeting Lp(a) may contribute to the primary prevention of AF. CA.ME.LI.A (CArdiovascular risks, MEtabolic syndrome, LIver and Autoimmune disease) is a cross-sectional, epidemiological study performed between 2009-2011 in Abbiategrasso (Milan, Italy) to estimate the prevalence of cardiovascular risk factors, metabolic syndrome, liver and autoimmune diseases in the general adult population. Linrodostat This report focuses on the description and presentation of baseline characteristics of the population. Citizens were randomly selected from the city electoral registers (n=30903), yielding a sample of 2554 subjects (M=1257, F=1297; age, 47±15yrs; range 18-77yrs). Men had higher prevalence of overweight or obesity (60.8% vs 41.6%; p<0.0001) and greater thickness of visceral adipose tissue (40±19 vs 27±17mm; p<0.0001); no gender difference was found in subcutaneous adipose tissue thickness. Men also showed higher levels of serum triglycerides, γ-GT, fasting blood glucose, insulin and Homa-IR Index, while HDL, CRP, and prevalence of elevated (>5.0mg/L) CRP were lower. Compared to normal weight men, risk-ratio (RR) of CRP elevation was 1.