Taken together, our findings demonstrate that miR-424-5p regulates ferroptosis by targeting ACSL4 in ovarian cancer cells and suggest a potential therapeutic approach for ovarian cancer.Following cue-outcome (X-O) pairings, 2 procedures that reduce conditioned responses to X are extinction, in which X is presented by itself, and counterconditioning, in which X is paired with a different outcome typically of valence opposite that of training. Although studies with animals have generally found counterconditioning more efficient than extinction in reducing responding, data from humans are less clear. They suggest counterconditioning is more efficient than extinction at interfering with emotional processing, but there is little difference between the two procedures regarding their impact on the verbal assessment of the probability of the outcome given the cue. However, issues of statistical power leave conclusions ambiguous. We compared counterconditioning and extinction in highly powered experiments that exploited a novel procedure. A rapid streamed-trial procedure was used in which participants were asked to rate how likely a target outcome was to accompany a target cue after being exposed to (PsycInfo Database Record (c) 2020 APA, all rights reserved).The renewal effect is often explained as a side effect of the extinction context acting as a negative occasion setter. Four experiments tested whether extinction contexts show the selective-transfer property of occasion setters. Experiments 1-3 used a predictive judgment task where participants rated the probability of certain foods (cues) producing gastric malaise (outcomes) in different restaurants (contexts). Experiment 4 used a behavioral suppression task where sensor lights (cues) served as signals to suppress firing responses in certain galaxies (contexts). All 4 (Experiments 1-4) addressed whether a potentially negative occasion-setting context transferred its modulatory power to an extinguished (presumably occasion set) target in the test phase of an ABC renewal design. Experiments 2-4 further assessed the possibility that the extinction context acts as a conditioned inhibitor by testing a simple excitor on a context where extinction occurred. Neither selective (occasion-setting) nor nonselective transfer (conditioned inhibition) was demonstrated. Implications for theories of renewal and occasion-setting are discussed. (PsycInfo Database Record (c) 2020 APA, all rights reserved).Given the high comorbidity among psychological disorders, and in particular, personality disorders (PDs) and alcohol use disorder, screening and intervention efforts may benefit from the inclusion of transdiagnostic symptoms. Extant symptoms can improve the ability to efficiently gather important information about an individual that relates to a number of conditions, behaviors, and potential problems. Further, less time is needed to assess these symptoms, as compared with full diagnostic criteria sets, which have limitations of their own. This study examined the utility of two PD symptoms, affective instability and impulsivity, as compared with relevant categorical diagnoses (antisocial and borderline PDs), to provide useful information about alcohol use disorder and heaviness of alcohol consumption. Individual symptoms were comparable to the categorical diagnoses in predicting important treatment targets. In an effort to identify and treat comorbidities in a more efficient way, future research should investigate the applicability of these individual symptoms, and other transdiagnostic targets, to screening and brief intervention protocols. (PsycInfo Database Record (c) 2020 APA, all rights reserved).The Levels of Personality Functioning Scale-Brief Form 2.0 (LPFS-BF 2.0) is a new measure of personality functioning according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition's, alternative model of personality disorders, containing a total personality functioning score and two subscales (Self and Interpersonal). The LPFS-BF 2.0 has limited evidence of validity among older adults. Subsequently, this study examined relationships between the LPFS-BF 2.0 and anxiety, interpersonal functioning, and normative personality traits to establish convergent validity. In all, 130 community-dwelling older adults (Mage = 64.61) completed the LPFS-BF 2.0, Geriatric Anxiety Scale, Circumplex Scales of Interpersonal Problems (CSIP), and Big Five Inventory-2 (BFI-2). Internal consistency (Cronbach's α) was acceptable to good for each of the LPFS-BF 2.0 scale scores (Self, α = .74; Interpersonal, α = .85; Total Personality Functioning, α = .79). Correlations were computed between the LPFS-BF 2.0 scales and the Geriatric Anxiety Scale, CSIP, and BFI-2. Overall, significant correlations were detected in expected directions. Additionally, to further establish convergent validity, regression analyses were conducted with the CSIP and BFI-2 scales predicting each of the LPFS-BF 2.0 scales. The models accounted for significant variance, and significant predictors were found in anticipated and theoretically consistent directions. Results provide strong but initial psychometric support for the use of the LPFS-BF 2.0 as an assessment tool for measuring personality functioning among older adults. An implication is that this measure may be used to identify important personality features that are part of a full assessment of personality pathology. (PsycInfo Database Record (c) 2020 APA, all rights reserved).Antisocial personality is generally used to describe people who treat other people with callous disregard and disrespect. Although animal cruelty is diagnostic of conduct disorder, a precursor of antisocial personality in children, it is unclear whether the term antisocial also encompasses disregard and disrespect toward nonhuman animals among adults. In this study, we examined associations between three antianimal attitudes and behaviors-speciesism, hunting/fishing, and lack of sympathy for animal rights-and traits that underlie adult antisocial behavior. click here We found consistent links between antisocial personality traits and antianimal attitudes and behaviors in 2 samples. These effects were generally specific to traits linked to antisociality (although we also found associations with low openness), and these traits were stronger as predictors of variation among meat eaters than as predictors of differences between vegetarians and meat eaters. These results suggest that the term antisocial applies to negative attitudes and behaviors toward both humans and nonhuman animals and imply the potential value of considering antianimal attitudes and behaviors in the clinical assessment of antisocial personality.