Background Reduced postoperative mobility predisposes older patients with hip fractures to a variety of complications, including acute cerebral infarction, pressure injury, deep vein thrombosis of the lower limbs, and lung and urinary tract infections caused by prolonged bed rest. This study was designed to explore the relationship between common postoperative complications of prolonged bed rest and quality of life in hospitalized elderly hip fracture patients, in an attempt to inform the development of relevant interventions. Methods A total of 502 patients aged 65 years or above who underwent hip fracture surgery in our center were enrolled in this study. The patients' basic information and details of complications during their hospitalization was obtained from the case report form. The patients received telephone follow-up after discharge, and their quality of life (QoL) was measured by using the European Quality of Life Five Dimension Five Level Scale (EQ-5D-5L). Results During hospitalization, 98 patients (19.52%) experienced at least 1 common complication including acute cerebral infarction (n=15, 2.99%), pressure injury (n=25, 4.98%), deep vein thrombosis of the lower limbs (n=14, 2.79%), pulmonary infections (n=84, 16.73%), and urinary tract infections (n=30, 5.98%). The proportion of patients who reported problems including mobility, self-care, usual activities, pain/discomfort, and anxiety/depression was higher in those who experienced complications. Conclusions Active prevention of common complications caused by prolonged bed rest can improve the QoL and reduce the disease burden for elderly patients with hip fractures.Background Perianal infection is a common complication in patients with acute leukemia receiving chemotherapy. It usually manifests as a perianal mass, with redness/swelling, heat, and pain, and can affect physical and mental health in severe cases. The purpose of this study was to investigate the effectiveness of matrine sitz bath (MSB) in treating perianal infection after chemotherapy for acute leukemia. Methods A total of 216 acute leukemia patients with perianal infection that developed during chemotherapy were enrolled in this study and equally randomized into an MSB group and control group. The control group was treated with the conventional potassium permanganate sitz bath. After 14 days of treatment, the clinical efficacy and symptom/sign scores were compared between these 2 groups. The serum levels of high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α), interleukin-10(IL-10), erythrocyte sedimentation rate (ESR), and prostaglandin E2 (PGE2) were detected by using enzyme-linked immunosorbent assay (ELISA). Results The clinical efficacy of MSB group was significantly superior to that of the control group (P less then 0.05). The scores of anal pain, systemic symptoms, mass size, and mass texture were significantly decreased after treatment in both groups (P less then 0.05), and they were significantly lower in the MSB group than in the control group (P less then 0.05). After treatment, the serum levels of hs-CRP, TNF-α, ESR, and PGE2 in these 2 groups significantly dropped (P less then 0.05), and they were significantly lower in the MSB group than in the control group (P less then 0.05); IL-10 level significantly rose in both groups (P less then 0.05), and it was significantly higher in the MSB group than in the control group (P less then 0.05). Evofosfamide Conclusions MSB is effective in treating perianal infection after chemotherapy for acute leukemia as it can effectively improve symptoms and signs and alleviate inflammatory reactions.Background Sepsis continues to carry a high rate of mortality, which makes effective and simple evaluation methods for predicting the prognosis of septic patients especially important. In this study, we retrospectively analyzed the relationships between three scoring systems including Sequential Organ Failure Assessment (SOFA) score, Quick SOFA (qSOFA) score, and Logistic Organ Dysfunction System (LODS) score and the prognoses of septic patients. Methods The baseline data, SOFA score, qSOFA score, LODS score, 28-day prognosis, and 90-day prognosis of patients who met the diagnostic criteria of sepsis were retrieved from the Medical Information Mart for Intensive Care III (MIMIC-III) database. Receiver operating characteristic (ROC) curves were drawn for various indicators, and comparisons were drawn between the areas under the ROC curves (AUC) of the different scoring systems. Results The 28-day AUC was 0.661 (0.652, 0.670) for SOFA, 0.558 (0.548, 0.568) for qSOFA, and 0.668 (0.658, 0.677) for LODS; AUC-qSOFA vs. AUC-LODS was 0.103 (0.087, 0.120) (P less then 0.001), and AUC-qSOFA vs. AUC-LODS was 0.110 (0.094, 0.125) (P less then 0.001). The 90-day AUC was 0.630 (0.621, 0.640) for SOFA, 0.551 (0.541, 0.560) for qSOFA, and 0.644 (0.635, 0.653) for LODS; AUC-SOFA vs. AUC-qSOFA was 0.079 (0.065, 0.094) (P less then 0.001), and AUC-qSOFA vs. AUC-LODS was 0.093 (0.079, 0.107) (P less then 0.001). Conclusions SOFA score, qSOFA score, and LODS score can all be used to predict the prognosis of septic patients. LODS score and SOFA score have higher accuracy than qSOFA score; however, qSOFA is simpler to use, making it a more suitable tool in an emergency setting.Background Multiple organ failure complicated by coagulation dysfunction is an important cause of death in patients with sepsis. This study aimed to explore the clinical significance of platelet maximum aggregation rate (MAR) in patients with sepsis and explored the relationship between MAR and prognosis to support treatment decision-making. Methods Blood samples from patients with sepsis (diagnosed according to the 2016 international diagnostic criteria for sepsis 3.0) treated between Sep 2017 and Apr 2018 were assessed. Patients were excluded if they had any other condition or treatment that may have affected platelet function in the previous 2 weeks. A control group of healthy subjects attending the physical examination center in the same period was also included. The MAR was measured using a whole blood platelet function analyzer (PL-12) using a range of different inducers of platelet aggregation, and normal saline. MAR was assessed in the healthy and septic groups, and survivors and non-survivors were compared in the sepsis group 28 days after treatment.