Thus, contamination of well water by this carbapenem-resistant and presumptively virulent strain of R. ornithinolytica should be considered a potential public health risk. Pathways for the physical disintegration of biochar (BC) and the release of water dispersible BC colloids (WDBC) have received much attention due to their unique impacts on carbon loss and contaminant. However, the current understanding of the mechanisms involved in WDBC formation and associated influencing factors is rather limited. This study systematically explored the effects of pyrolysis temperature, initial particle size, and solution chemistry on WDBC formation in aqueous solutions and examined the formation and colloidal stability of WDBC in natural solutions. Results showed that pyrolysis temperature determined the abrasion resistance of pyrolyzed BC, and the submicron fragment rate decreased in the order 400 °C (BC400) > 700 °C (BC700) > 200 °C (BC200). The WDBC yield decreased in the order BC400 (77.5-331 mg g-1) > BC700 (33.5-173 mg g-1) > BC200 (16.8-125 mg g-1) depending on BC size at a solution ionic strength (IS) ≤ 1 mM, which was positively correlated with the submicron fragment rate of bulk BC. With the exception of BC200, increasing IS (0.1-20 mM) and decreasing pH (3.0-10.0) significantly inhibited WDBC yield. Release and sedimentation dominated the WDBC formation processes with the former being more susceptible to solution chemistry. Derjaguin-Landau-Verwey-Overbeek interactions properly explained the effect of IS on WDBC from BC400 and BC700, while the steric resistance of abundant dissolved organic carbon on BC200 was mainly responsible for the high formation of WDBC at high IS (20-50 mM). WDBC had high colloidal stability and could form and stabilize well in natural surface waters and soil solutions, suggesting the relevant risk of long-distance migration of WDBC in environments. These findings represent new knowledge regarding the physical decomposition and the fate of BC in the environment. Poyang Lake is the largest freshwater lake in China and a globally important wetland with various functions. selleck inhibitor Exploring the multidecadal trend of water quality and hydroclimatic conditions is important for understanding the adaption of the lake system under the pressure from multiple anthropogenic and meteorological stressors. The present study applied the Mann-Kendall trend analysis and Pettitt test to detect the trend and breakpoints of hydroclimatic, and water quality parameters (from the 1980s to 2018) and the trend of monthly-seasonal ammonia (NH4-N) and total phosphorus (TP)concentrations (from 2002 to 2018) in Poyang Lake. Results showed that Poyang Lake had undergone a highly significant warming trend from 1980 to 2018, with a warming rate of 0.44 °C/decade in terms of annual daily mean air temperature. The wind speed and water level of the lake presented a highly significant decreasing trend, whereas no notable trend was detected for precipitation variations. The annual mean total nitrogen (TN), NH4-N, TP, and permanganate index (CODMn) concentrations showed significant upward trends from the 1980s to 2018. Remarkable abrupt shifts were detected for TN, NH4-N, and CODMn in around 2003. They were in accordance with the water level breakpoint of the lake, thus implying the important role of hydrological conditions in water quality variations in floodplain lakes. A significant increasing trend has been detected for Chl-a variations during wet season from 2008 to 2018, which could be attributed to the increasing trend of nutrient concentration during the nutrient-limited phase of Poyang Lake. These hydroclimatic and water quality trends suggest a high risk of increasing phytoplankton growth in Poyang Lake. This study thus emphasizes the need for adaptive lake eutrophication management for floodplain lakes, particularly the consideration of the strong trade-off and synergies between hydroclimatic conditions and water quality variations. Growing evidence suggests that anthropogenic noise has deleterious effects on the behavior and physiology of free-living animals. These effects may be particularly pronounced early in life, when developmental trajectories are sensitive to stressors, yet studies investigating developmental effects of noise exposure in free-living populations remain scarce. To elucidate the effects of noise exposure during development, we examined whether noise exposure is associated with shorter telomeres, duller carotenoid-based coloration and reduced body mass in nestlings of a common urban bird, the great tit (Parus major). We also assessed how the noise environment is related to reproductive success. We obtained long-term measurements of the noise environment, over a ∼24-h period, and characterized both the amplitude (measured by LAeq, LA90, LA10, LAmax) and variance in noise levels, since more stochastic, as well as louder, noise regimes might be more likely to induce stress. In our urban population, noise levels varied sf early-life telomere length. Although association between polycyclic aromatic hydrocarbons (PAHs) exposure and mitochondrial DNA copy number (mtDNAcn) was researched by traditional linear model extensively, most of these studies analyzed independent effect of each PAHs metabolite and adjust for the confounding other metabolites concomitantly, without considering others interactions. As a complex organic pollutant, a reasonable statistical method is needed to study toxic effects of PAHs. Therefore, we aimed to conduct a novel statistical approach, Bayesian Kernel Machine Regression (BKMR), to explore the effect of PAHs exposure on mtDNAcn among coke oven workers. In this cross-sectional study, the concentrations urinary of PAHs metabolites were measured using high performance liquid chromatography mass spectrometry (HPLC-MS). The mtDNAcn was measured using real-time quantitative polymerase chain reaction (RT-PCR) in peripheral blood of 696 Chinese coke oven workers. The relationship of urinary of PAHs metabolites and mtDNAcn were evaluated by BKMR model. And the results showed a significant negative effect of PAHs metabolites on mtDNAcn when PAHs metabolites concentrations were all above 35th percentile compared to the median and the statistically significant negative single-exposure effect of 2-OHNAP and 2-OHPHE on mtDNAcn when all of the other PAHs are fixed at a particular threshold (25th, 50th, 75th percentile). The changes in log 2-OHNAP and 2-OHPHE from the 25th to the 75th percentile when other PAHs metabolites were at the 50th percentile were associated with change in mtDNAcn of -0.082 (-0.021, -0.124) and -0.048 (-0.021, -0.090) respectively. And evidence of a linear effect of urinary 2-OHNAP and 2-OHPHE were found. Finally, our findings suggested that PAHs cumulative exposures and particularly single-exposure of 2-OHNAP and 2-OHPHE might compromise mitochondrial function by decreasing mtDNAcn in Chinese coke oven workers.