Web-based resources for tobacco use prevention and control provide valuable tools for cancer education. This study sought to (a) identify existing websites that archive prevention and cessation media content and (b) characterize the content and features of those websites. We used a comprehensive search strategy to identify web-based resources. Websites were included if (1) the content was focused on tobacco; (2) a primary purpose of the website was to house a national or international historical archive of anti- or pro-tobacco media or communication content; and (3) the website was designed for researchers or practitioners. Of the 55 websites initially identified, N = 9 met criteria. All websites contained anti-tobacco media content (100%), although 56% also contained pro-tobacco content. Retatrutide Most websites focused on multiple tobacco products (89%), while 11% focused solely on cigarettes. The most common media content in the archives were print ads (67%), warning labels (56%), and video ads (33%). Most archives contained a search function or content filters (67%). While most websites provided free media content with no restrictions (78%), 22% contained paid or restricted content. Other website material included research reports (89%), newsfeeds (89%), fact sheets (67%), advocacy information (56%), and tools for practitioners (44%). This study provides a systematic summary of web-based tobacco prevention and control resources that archive communication and media content. The identified websites can assist researchers and practitioners in their tobacco control efforts, although additional archives focused specifically on vaping media and communication content are needed as the vaping epidemic among youth continues to intensify. Inhalation therapy involves two types of adherence adherence to the drug and adherence to the procedures for the inhalation device. User satisfaction and preference are key factors for maintaining good adherence of both types, and they should be evaluated based on three conditions being well maintained asthma control level (ACL), adherence, and adequate device operability during usage duration. We compared user satisfaction and preference between a pressurized metered-dose inhaler (pMDI) and a dry powder inhaler (Ellipta), while maintaining the three conditions during usage in stable asthma patients. In this open-label, randomized, two-way crossover study, patients with stable asthma [Asthma Control Questionnaire (ACQ) scores < 0.75] were classified into a 20-64-year age group (G1) and a ≥ 65-year age group (G2) and randomly assigned to either a formoterol/fluticasone combination (FFC) as the pMDI group or a vilanterol/fluticasone combination (VFC) as the Ellipta group. Satisfaction and preference leve. Japan Registry of Clinical Trials identifier, jRCTs041180001 (registered 21 August 2018).Japan Registry of Clinical Trials identifier, jRCTs041180001 (registered 21 August 2018). The biological pathways related to Arabidopsis seed development have been well studied and functional genes involved in it have been discovered. However, functional studies about maize seed development were more limited compared to Arabidopsis. Therefore, transferring knowledge from Arabidopsis into maize would facilitate functional studies about maize seed development. In this study, public transcriptome data of the two species related to seed development were obtained. Co-expression network in each species was compared by integrating orthology information. This conserved co-functional network contained 4510 maize and 4808 Arabidopsis genes, respectively. Most of these genes were expressed in throughout embryo, early or later endosperm/seed. These conserved co-functional genes were significantly enriched for members of PPR protein family, which was consistent with that PPR proteins play an important role in maize seed development. Spatial-temporally co-functional genes were discovered in the seed coat and embryo. Furthermore, 66 well-studied genes involved in Arabidopsis seed development were co-functional with 319 maize genes and one maize gene (GRMZM2G036050) was further confirmed using an EMS-induced seed defective mutant by bulked segregating RNA sequencing (BSR) analysis. Altogether, these results showed the potential of this approach to support functional studies in maize seed development by transferring knowledge from Arabidopsis.Altogether, these results showed the potential of this approach to support functional studies in maize seed development by transferring knowledge from Arabidopsis.Approximately 10% of children with newly diagnosed cancer have a cancer predisposition syndrome (CPS). The optimal diagnostic approach to identify them among children diagnosed with cancer is unknown. To determine whether the use of a one-page questionnaire can improve the CPS diagnosis among children with an oncologic condition. Comparative effectiveness research. Referral center for children with cancer. 739 children diagnosed with an oncologic condition between 2012 and 2019. All children with a newly diagnosed oncologic condition presenting to Hannover Medical School between January 1st 2017 and December 31st 2019 were prospectively evaluated with a CPS questionnaire. Children in whom the questionnaire suggested the need of a genetic workup were further evaluated. All children diagnosed with an oncologic condition between January 1st 2012 and December 31st 2016 served as control. The CPS diagnoses established during both time periods were evaluated and compared. A CPS was diagnosed in 27 out of 287 children (9.4%) during the questionnaire period versus 24 out of 452 children (5.3%) during the control period (P = 0.032). The CPS questionnaire appears to significantly improve the diagnosis of children with CPS among children with a newly diagnosed oncologic condition.The CPS questionnaire appears to significantly improve the diagnosis of children with CPS among children with a newly diagnosed oncologic condition. It is with a great prospect to develop an auxiliary diagnosis system for dental periapical radiographs based on deep convolutional neural networks (CNNs), and the indications and performances should be investigated. The aim of this study is to train CNNs for lesion detections on dental periapical radiographs, to evaluate performances across disease categories, severity levels, and train strategies. Deep CNNs with region proposal techniques were constructed for disease detections on clinical dental periapical radiographs, including decay, periapical periodontitis, and periodontitis, leveled as mild, moderate, and severe. Four strategies were carried out to train corresponding networks with all disease and level categories (baseline), all disease categories (Net A), each disease category (Net B), and each level category (Net C) and validated by a fivefold cross-validation method afterward. Metrics, including intersection over union (IoU), precision, recall, and average precision (AP), were compared across diseases, severity levels, and train strategies by analysis of variance.