IEA patients had more frequently postoperative delirium and stayed for longer at PACU and at the hospital. IEA was a common phenomenon after anesthesia for elective curative surgery for cancer. Patients with IEA were older and had more comorbidities and a higher surgical risk. Patients with IEA had a less frequent complete recovery on the PD and in AD domains, and a more frequent complete recovery on the ED.IEA was a common phenomenon after anesthesia for elective curative surgery for cancer. Patients with IEA were older and had more comorbidities and a higher surgical risk. Patients with IEA had a less frequent complete recovery on the PD and in AD domains, and a more frequent complete recovery on the ED. Neuropathic pain is common in the general population worldwide and Brazil. read more The painDETECT questionnaire is a notable instrument for screening on neuropathic pain. A Brazilian version of the painDETECT is necessary to broaden the possibilities of identification of neuropathic pain in the Brazilian population for the proper diagnosis and treatment. The current study aimed to perform the translation and cross-cultural adaptation of the painDETECT into the Portuguese language of Brazil. A cross-cultural adaptation study was conducted in 11 stages according to standard procedures. Descriptive statistics were performed. The internal consistency of the questionnaire was assessed using Cronbach's Alpha test (α). Four translators, 10 experts, and 30 patients participated in the study. The expert committee adapted five out of nine items (item 2, 3, 6, 8, and 10) to the Brazilian context. The pretesting phase showed good internal consistency (α=0.74) for the nine items, including the pain pattern and the body chart domains. The Cronbach's α of the instrument with seven descriptor items of pain was 0.83. The painDETECT was cross-culturally adapted into a Brazilian context and can be used to identify neuropathic components in pain of Brazilian patients. PainDETECT is available for Brazilians to identify neuropathic components in pain.PainDETECT is available for Brazilians to identify neuropathic components in pain. Sparse representation-based classification (SRC) has more advantages in motor imagery EEG pattern recognition, and the quality of dictionary construction directly determines the performance of SRC. In this paper, we proposed a two-dimensional dictionary optimization (TDDO) method to directly improve the performance of SRC. Firstly, an initial dictionary was constructed with multi-band features extracted by filter band common spatial pattern (FBCSP). Then Lasso regression is used to select significant features in each atom synchronously in the horizontal direction, and the KNN-based method is used to clean up noise atoms in the vertical direction. Finally, an SRC method by training samples linearly representing test samples was implemented in classification. The results show the necessity and rationality of TDDO-SRC method. The highest average classification accuracy of 86.5% and 92.4% is obtained on two public datasets. The proposed method has more superior classification accuracy compared to traditional methods and existing winners' methods. The quality of dictionary construction has a great impact on the robustness of SRC. And compared with the original SRC, the classification accuracy of the optimized TDDO-SRC is greatly improved.The quality of dictionary construction has a great impact on the robustness of SRC. And compared with the original SRC, the classification accuracy of the optimized TDDO-SRC is greatly improved.As expressed by the "Healthy is Up" metaphor, conceptual metaphor theory argues that the representation of health is commonly associated with high verticality because, typically, people stay upright when they are healthy whereas illness may force them to lie down. Along this line of argument, this research is the first to empirically explore the metaphorical representation of healthy food in terms of verticality. Across five experiments (N = 714), this article first demonstrates that people are faster to pair healthy food with up than down in an implicit association test (Study 1, supporting a metaphorical congruency effect). Then, it shows that people associate healthy food with high verticality and unhealthy food with low verticality by placing healthy food up high and unhealthy food low down along the vertical axis, and by preferring a food pyramid that depicts healthy food at the top rather than at the bottom (Studies 2a, 2b and 3, supporting an abstract-to-concrete effect). Last, this research finds that people judge a food product as healthier when it is pictured from an upward-looking angle than when it is pictured from a downward-looking angle (Study 4, supporting a concrete-to-abstract effect). Further analyses test the interaction between individual differences in self-control and the effects of the "Healthy is Up" metaphor in Studies 2a, 2b, 3 and 4. The article concludes with a discussion of the theoretical and practical implications of this research.Ischemic white matter damage (WMD) is increasingly being considered as one of the major causes of neurological disorders in older adults and preterm infants. The functional consequences of WMD triggers a progressive cognitive decline and dementia particularly in patients with ischemic cerebrovascular diseases. Despite the major stride made in the pathogenesis mechanisms of ischemic WMD in the last century, effective medications are still not available. So, there is an urgent need to explore a promising approach to slow the progression or modify its pathological course. In this review, we discussed the animal models, the pathological mechanisms and the potential therapeutic agents for ischemic WMD. The development in the studies of anti-oxidants, free radical scavengers, anti-inflammatory or anti-apoptotic agents and neurotrophic factors in ischemic WMD were summarized. The agents which either alleviate oligodendrocyte damage or promote its proliferation or differentiation may have potential value for the treatment of ischemic WMD. Moreover, drugs with multifaceted protective activities or a wide therapeutic window may be optimal for clinical translation.