Energy-constrained biomedical recording systems need power-efficient data converters and good signal compression in order to meet the stringent power consumption requirements of many applications. In literature today, typically a SAR ADC in combination with digital compression is used. Recently, alternative event-driven sampling techniques have been proposed that incorporate compression in the ADC, such as level-crossing A/D conversion. This paper describes the power efficiency analysis of such level-crossing ADC (LCADC) and the traditional fixed-rate SAR ADC with simple compression. A model for the power consumption of the LCADC is derived, which is then compared to the power consumption of the SAR ADC with zero-order hold (ZOH) compression for multiple biosignals (ECG, EMG, EEG, and EAP). The LCADC is more power efficient than the SAR ADC up to a cross-over point in quantizer resolution (for example 8 bits for an EEG signal). This cross-over point decreases with the ratio of the maximum to average slope in the signal of the application. It also changes with the technology and design techniques used. The LCADC is thus suited for low to medium resolution applications. In addition, the event-driven operation of an LCADC results in fewer data to be transmitted in a system application. The event-driven LCADC without timer and with single-bit quantizer achieves a reduction in power consumption at system level of two orders of magnitude, an order of magnitude better than the SAR ADC with ZOH compression. At system level, the LCADC thus offers a big advantage over the SAR ADC.In this article, a novel method for measuring the volume of the urinary bladder non-invasively is presented that relies on the principles dictated by Electrical Impedance Tomography (EIT). The electronic prototype responsible for injecting innocuous electrical currents to the lower abdominal region and measuring the developed voltage levels is fully described, as well as the computational models for resolution of the so-called Forward and Inverse Problems in Imaging. The simultaneous multi-tone injection of current provided by a high performance Field Programmable Gate Array (FPGA), combined with impedance estimation by the Discrete Fourier Transform (DFT) constitutes a novelty in Urodynamics with potential to monitor continuously the intravesical volume of patients in a much faster and comfortable way than traditional transurethral catheterization methods. The resolution of the Inverse Problem is performed by the Gauss-Newton method with Laplacian regularization, allowing to obtain a sectional representation of the volume of urine encompassed by the bladder and surrounding body tissues. Experimentation has been carried out with synthetic phantoms and human subjects with results showing a good correlation between the levels of abdominal admittivity acquired by the EIT system and the volume of ingested water.Chronic neurological disorders (CND's) are lifelong diseases and cannot be eradicated, but their severe effects can be alleviated by early preemptive measures. CND's, such as Alzheimer's, Autism Spectrum Disorder (ASD), and Amyotrophic Lateral Sclerosis (ALS), are the chronic ailment of the central nervous system that causes the degradation of emotional and cognitive abilities. Long term continuous monitoring with neuro-feedback of human emotions for patients with CND's is crucial in mitigating its harmful effect. This paper presents hardware efficient and dedicated human emotion classification processor for CND's. Scalp EEG is used for the emotion's classification using the valence and arousal scales. A linear support vector machine classifier is used with power spectral density, logarithmic interhemispheric power spectral ratio, and the interhemispheric power spectral difference of eight EEG channel locations suitable for a wearable non-invasive classification system. A look-up-table based logarithmic division unit (LDU) is to represent the division features in machine learning (ML) applications. The implemented LDU minimizes the cost of integer division by 34% for ML applications. The implemented emotion's classification processor achieved an accuracy of 72.96% and 73.14%, respectively, for the valence and arousal classification on multiple publicly available datasets. The 2 x 3mm2 processor is fabricated using a 0.18 μm 1P6M CMOS process with power and energy utilization of 2.04 mW and 16 μJ/classification, respectively, for 8-channel operation.This paper presents a device for time-gated fluorescence imaging in the deep brain, consisting of two on-chip laser diodes and 512 single-photon avalanche diodes (SPADs). The edge-emitting laser diodes deliver fluorescence excitation above the SPAD array, parallel to the imager. In the time domain, laser diode illumination is pulsed and the SPAD is time-gated, allowing a fluorescence excitation rejection up to O.D. 3 at 1 ns of time-gate delay. Each SPAD pixel is masked with Talbot gratings to enable the mapping of 2D array photon counts into a 3D image. The 3D image achieves a resolution of 40, 35, and 73 μm in the x, y, and z directions, respectively, in a noiseless environment, with a maximum frame rate of 50 kilo-frames-per-second. We present measurement results of the spatial and temporal profiles of the dual-pulsed laser diode illumination and of the photon detection characteristics of the SPAD array. Finally, we show the imager's ability to resolve a glass micropipette filled with red fluorescent microspheres. The system's 420 μm-wide cross section allows it to be inserted at arbitrary depths of the brain while achieving a field of view four times larger than fiber endoscopes of equal diameter.We propose a new paradigm of a smart wireless endoscopic capsule (WCE) that has the ability to select suspicious images containing a polyp before sending them outside the body. EPZ020411 molecular weight To do so, we have designed an image processing system to select images with Regions Of Interest (ROI) containing a polyp. The criterion used to select an ROI is based on the polyp's shape. We use the Hough Transform (HT), a widely used shape-based algorithm for object detection and localization, to make this selection. In this paper, we present a new algorithm to compute in real-time the Hough Transform of high definition images (1920 x 1080 pixels). This algorithm has been designed to be integrated inside a WCE where there are specific constraints a limited area and a limited amount of energy. To validate our algorithm, we have realized tests using a dataset containing synthetic images, real images, and endoscopic images with polyps. Results have shown that our algorithm is capable to detect circular shapes in synthetic and real images, but also can detect circles with an irregular contour, like that of polyps.