Age is a key factor in plantar pressure distributions during the development of obese children. However, the existing evidence for age-related plantar pressures of obese children is not sufficient to make clear how the plantar pressures would change with the increasing age. This study aimed to evaluate the plantar pressure redistributions of obese children after a three-year follow-up and to further compare these changes with normal-weighted children. Ten obese children and eleven normal-weighted counterparts were involved in this study. Plantar pressure measurements were undertaken using a Footscan® plantar pressure plate on two test sessions three years apart. Peak pressure, pressure-time integral, standard maximum force, and z-scores of these variables were analyzed. Loading transference analyses were applied to detect the different loading transferring mechanisms between obese and normal-weighted children. Significantly increased plantar pressures were observed at the lateral forefoot and midfoot for obese children, which gradually deviated from those of normal-weighted children over the 3 years. With the increasing age, obese children displayed a lateral loading shift at the forefoot in contrast to the normal-weighted. Early interventions are cautiously recommended for obese children before the plantar loading deviation gets worse as they grow older.Using low-cost gas sensors for air quality monitoring promises cost effective and convenient measurement systems. Nevertheless, the results obtained have a questionable quality due to different factors that can affect sensor performance. The most discussed ones are relative humidity and air temperature. This investigation aimed to assess the behavior of B4-series low-cost gas sensors from Alphasense for measuring CO, NO, NO2, and O3 for different levels of relative humidity and temperature. These low-cost gas sensors were tested for six relative humidity levels from 10% to 85% with increasing steps of 15% and four temperature levels of 10 °C, 25 °C, 35 °C, and 45 °C against reference instruments in the laboratory. The effect of these parameters on low-cost gas sensors was quantified in laboratory from which a correction algorithm was calculated, which was then applied to the field data. The applied algorithm improved the data quality of the low-cost gas sensors in most of the cases. Additionally, a low-cost dryer was assessed to reduce the influence of these factors on the low-cost gas sensors, which also proved to be suitable to enhance the data quality.Although 91% of 12-23-month-old children in Indonesia received at least one immunization in 2013, only 76% completed DTP3 immunization. click here This percentage is below the UNICEF and WHO recommended standards. Thus, this study aims to investigate trends, spatial disparities, and social determinants related to low coverage of DTP3 immunization in Indonesia. Using a multilevel approach, we analyzed data from 305,090 12-23-month-old children living across approximately 500 districts in Indonesia to study demand and supply factors determining DTP3 immunization status. We examined unique, nationally representative data from the National Socioeconomic Survey (Survei Sosial Ekonomi Nasional or Susenas) and Village Potential Census (Potensi Desa or Podes) from 2004 to 2016. The percentage of children receiving complete DTP3 immunization increased from 37.8% in 2004 to 75.9% in 2016. Primarily income, parity status, and education, showed influence on DTP3 coverage. Among individual-level factors, the presence of a professional birth attendant was the most influential factor. At the district level, the factors varied. Low progress in DTP3 immunization status in Indonesia is due to huge disparities across the country's islands, in the density of health services, and in household socioeconomic status.Improving life expectancy, as well as people's health and wellbeing, is an important goal both for the Chinese government and the United Nations. Therefore, to analyze the main factors influencing life expectancy in prefecture-level cities in China, this study uses classical ordinary least-squares regression and geographical weighted regression on the data of the latest census. Moreover, regional differences induced by each influencing factor are also depicted in this study. The results demonstrate that there is significant heterogeneity and spatial positive correlation among the distribution of life expectancy in prefecture-level cities, with a generally higher life expectancy in the provincial capitals and eastern China, and lower in western China. The geographically weighted regression analysis shows that the economic development level, medical conditions, demographic structure, natural environment, and city attributes all affect the distribution of life expectancy, but that their effects have significant spatial heterogeneity. Life expectancy of the less developed areas in Western China is affected dominantly by economic development level, whereas medical services and education are of great importance in determining the life expectancy in Northern and Southern China, respectively. Thus, it is crucial to solve health problems based on local conditions, especially focusing on the improvement of health and health care in underdeveloped areas. Meanwhile, for the eastern developed areas, special attention should be paid to environmental protection in the economic process, while striving to achieve high-quality development.Phototropin2 (phot2) is a blue-light (BL) receptor protein that regulates the BL-dependent activities of plants for efficient photosynthesis. Phot2 is composed of two light-oxygen-voltage sensing domains (LOV1 and LOV2) to absorb BL, and a kinase domain. Photo-activated LOV domains, especially LOV2, play a major role in photo-dependent increase in the phosphorylation activity of the kinase domain. The atomic details of the overall structure of phot2 and the intramolecular mechanism to convert BL energy to a phosphorylation signal remain unknown. We performed structural studies on the LOV fragments LOV1, LOV2, LOV2-linker, and LOV2-kinase, and full-length phot2, using small-angle X-ray scattering (SAXS). The aim of the study was to understand structural changes under BL irradiation and discuss the molecular mechanism that enhance the phosphorylation activity under BL. SAXS is a suitable technique for visualizing molecular structures of proteins in solution at low resolution and is advantageous for monitoring their structural changes in the presence of external physical and/or chemical stimuli.