05). For the control group, HR at T3 was lower than that at T0 (P less then 0.05). HR at T3 of the treatment group was lower than that of the control group (P less then 0.05). SpO2 of the treatment group was higher than that of the control group at T3 (P less then 0.05). At T2 and T3, PASP, PADP and PAMP of both groups were lower than those before surgery (P less then 0.05), and the values of the treatment group were lower than those of the control group (P less then 0.05). CONCLUSIONS Treprostinil can improve cardiac function and reduce pulmonary circulation resistance in PAH children.Dysregulation of lncRNA cancer susceptibility candidate 2 (CASC2) is involved in the pathogenesis of multiple malignancies. However, the underlying mechanisms by which lncRNA CASC2 regulates the proliferation of hemangiomas (HAs) remain undocumented. Herein, the expression levels of lncRNA CASC2 and VEGF in proliferating or involuting phase HAs were assessed by qRT-PCR analysis, and the effects of lncRNA CASC2 on HAs cell growth were evaluated by MTT, colony formation assays and Western blot analysis. lncRNA CASC2 specific binding with miR-18a-5p was confirmed by luciferase report assay. Consequently, we found that the expression of lncRNA CASC2 was reduced in proliferating phase HAs as compared with the involuting phase HAs or normal tissues, and possessed a negative correlation with VEGF expression in proliferating phase HAs. Restored expression of lncRNA CASC2 repressed cell viability and colony formation and downregulated VEGF expression, while silencing lncRNA CASC2 showed the opposite effects. Moreover, lncRNA CASC2 was confirmed to bind with miR-18a-5p, which could reverse lncRNA CASC2-induced anti-proliferative effects by targeting FBXL3 in HAs cells. Altogether, our findings demonstrated that lncRNA CASC2 suppressed the growth of HAs cells by regulating miR-18a-5p/FBXL3 axis. Copyright 2020 Biolife Sas. www.biolifesas.org.Warfarin is known to interact with many drugs and can lead to serious consequences. We report a case of 52 years old female patient from Himachal Pradesh. During hospital stay patient developed coagulopathy in form of INR above 10 and bradycardia with ventricular rate on ECG with digoxin level of 3.76 ng/ml. In this way digoxin toxicity was confirmed and it was considered as cause of coagulopathy after ruling out interactions of warfarin. © Journal of the Association of Physicians of India 2011.Cough Syncope, a form of Neurocardiogenic Syncope, occurs immediately after coughing due to to arterial baroreflex-mediated vasodilatation. Cough syncope has been classically described in patients with obstructive pulmonary diseases. Pulmonary Vascular Diseases, though rare, also present with cough syncope. Malignant Syncope is defined as recurrent syncope with minimal warning, and often associated with self-injury. Here we describe how we managed a case of a young male presenting with recurrent attacks of Malignant Cough syncope. © Journal of the Association of Physicians of India 2011.Cases have been reported about refeeding syndrome after bariatric surgery for obesity, in head and neck cancer patients, in patients with anorexia nervosa, hyperemesis gravidarum, in persons on hunger strike, malnourished alcoholic persons and persons doing religious fasting. Refeeding after prolonged fasting can cause severe morbidity and even mortality, if not done properly. Depletion of intracellular electrolytes, depletion of nutrients and vitamins, decreased BMR, decreased renal functions, decreased insulin, decreased GI functions all contribute to it, once you start refeeding. It takes sometime to regain the original functions by the organs and mismatch between supply and increased demand after refeeding can cause havoc. Here we report the case of a person, who did water only fasting for 51 days and developed refeeding syndrome and Wernike's encephalopathy four days after starting liquid diet. © Journal of the Association of Physicians of India 2011.Immune thrombocytopenia is a well-known complication of both HIV and Hepatitis C virus infections. Management becomes challenging when a patient with HCV-HIV co-infection presents with severe thrombocytopenia. Adverse drug reactions and drug interactions has to be considered while choosing treatment options for such patients. We report such a case which illustrates the difficulty in managing severe thrombocytopenia in HCV-HIV co-infected patients where evidence based clinical decision making helped in choosing the right therapy for the patient. © Journal of the Association of Physicians of India 2011.The fourth industrial revolution refers to a fusion of technologies which blend the physical, digital and biological worlds. It can mitigate miseries of the teeming masses. However, India faces the unique challenge. It is both the creator of enormous amount of data required for this revolution as well as largest potential market for those innovations in the coming future. Alantolactone This article traces the challenges and draws parallels with the past experiences. The first transformation is expected to hit healthcare sector much sooner than projected earlier. It outlines the call to action required of our thought leaders today. © Journal of the Association of Physicians of India 2011.The 2019 Novel Corona virus infection (COVID 19) is an ongoing public health emergency of international significance. There are significant knowledge gaps in the epidemiology, transmission dynamics, investigation tools and management. In this article, we review the available evidence about this disease. Every decade has witnessed the evolution of a new coronavirus epidemic since the last three decades. The varying transmission patterns, namely, nosocomial transmission and spread through mildly symptomatic cases is an area of concern. There is a spectrum of clinical features from mild to severe life threatening disease with major complications like severe pneumonia, ARDS, acute cardiac injury and septic shock. Presence of bilateral ground glass opacity and consolidation on imaging in appropriate clinical background should raise a suspicion about COVID 19. Poor prognostic factors include Multilobular infiltration on chest imaging, Lymphopenia, Bacterial co-infection, Smoking history, Chronic medical conditions like Hypertension and age >60 years (MuLBSTA score).