Future research is needed to elucidate factors attributed to the change in PPT among patients with chronic pain, as well as the time that the CS occurs.Patients who suffer from chronic pain have a significantly lower PPT compared with healthy controls. Future research is needed to elucidate factors attributed to the change in PPT among patients with chronic pain, as well as the time that the CS occurs.In this Invited Commentary, the author applies a historical lens to explore a fundamental paradox in U.S. medical education the fact that long after women gained parity with men in matriculation to medical school, women remain highly underrepresented in leadership positions in academic medicine. The reasons for this are many and complex, but at the core are the subtle but hurtful indignities ("microinequities") experienced by women physicians and an academic culture that expects single-minded dedication to work, regardless of the costs to faculty members' personal lives. Achieving parity for women in academic leadership will require changing the culture of medical schools and teaching hospitals to correct these 2 fundamental obstacles. In recent years, many medical schools and teaching hospitals have made efforts to improve opportunities and satisfaction for women trainees and physicians, enacting reforms to improve work-life balance for all faculty. It is plausible to imagine a future in which flexible time frames to achieve tenure and promotion are universally available to both women and men, with high scholarly standards firmly maintained. If this occurs, it will represent a profound legacy for women in academic medicine, for their generations of professional sacrifice and advocacy for a more equitable culture will have changed its culture.What is the contribution of the 'Green Revolution' to improvements in child health during the 20th century? We provide global scale estimates of this relationship by constructing a novel, spatially-precise indicator of modern crop variety (MV) diffusion and leveraging child-level data from over 600,000 children across 21,604 sampling locations in 37 developing countries between 1961-2000. Results indicate that the diffusion of MVs reduced infant mortality by 2.4-5.3 percentage points (from a baseline of 18%), with stronger effects for male infants and among poor households. The sizable contribution of agricultural technology to improved welfare should inform global food and development policy.This article examines the legislation and practice of compulsory treatment in China. Part I traces the Chinese history of criminal commitment law, explains the research methodology, and highlights some general empirical findings. Part II provides a comprehensive empirical analysis of compulsory treatment law in China, it covers both substantial issues such as criteria of compulsory treatment and procedural issues such as the commitment hearing, enforcement, and discharge of compulsory treatment. It also explores the compulsory treatment law from the human rights protection perspective. Our primary objective is to present the empirical findings to enable the legislative and other involved government agencies to make informed decisions about the future evolution of Chinese law in this area.A large body of literature has documented the health promotive effects of healthy committed relationships on the health and wellbeing of heterosexual people in different-sex relationships, including observational and longitudinal studies, couple-based intervention development and evaluation efforts, and articulation of theoretical frameworks. A much smaller but growing field of research has observed that same-sex relationships have similar effects on health outcomes but that these couples face unique stressors that may impact relationship functioning and health. Further, extant theoretical frameworks do not sufficiently address the multiple pathways by which psychosocial vulnerabilities and stressors impact same-sex relationship functioning, engagement in health-related risk behaviors, and the mental and physical health of sexual minorities in relationships. The purpose of this manuscript is to a) review the existing literature on relationship functioning and health among sexual minorities, including both observational and intervention studies; and b) present an integrated model of relationship functioning and health for same-sex couples that can be used as a basis for further studies on sexual minority dyads, as well as the development of novel couple-based interventions to optimize the health promoting effects of relationships.Paper-based sensors can be exploited to develop low-cost, disposable, and rapid assays for the detection of a large variety of analytes. We report a paper-based sensor system for a point-of-care (POC) nucleic acid amplification test that can quantitatively detect multiple genes from different pathogens. The POC system combines a paper sensor chip and a portable instrument, which is built on an Internet of Things (IoT) platform. The paper-based sensor provides the functions of reagent storage, sample transportation, and nucleic acid amplification. The IoT instrument uses an Arduino microcontroller to control temperature, collect fluorescence images, and store the data in cloud storage via a WiFi network. A compact fluorescence reader was designed to measure fluorescence images of the amplicons during a loop-mediated isothermal amplification reaction in real-time. The real-time detection capability enables the quantitative analysis of target genes. The results show that the paper-based sensor cam distinguish multiple genes of the genomic DNA extracted from Escherichia coli and Campylobacter jejuni, with the concentration as low as 2 × 103 copies/μL. The affordable instrument, in conjunction with the disposable paper sensor chip, would have a great potential for POC detections of pathogens.Inexperienced drivers have a higher crash risk than others, particularly at night when drivers of all ages are at increased risk, but there has been little if any research on day-night differences in drivers' perceptions of risk and difficulty. Also, previous research on determinants of risk and difficulty ratings has focused largely on effects of vehicle speed, and researchers have identified a need to look more broadly at how ratings are affected by the complexity of depicted road-traffic situations. This study addressed those issues, using an exploratory approach entailing both quantitative and qualitative analyses. selleck chemicals The 62 participants (28 females, 34 males) were grouped according to level of driving experience and age (16-30 years). Determinants of ratings were investigated using 6 day-night pairs of video clips at 6 different locations, plus 2 night-only clips at 2 other locations (14 clips in all). Depicted driving situations varied naturalistically in complexity as well as speed. They were presented in random orders twice to each participant, who used a slider to rate each clip continuously, once for risk and once for difficulty in balanced order.