Objectives Mixed dopamine and serotonin receptor antagonists (DSRAs) are associated with significant weight gain and its complications. Our aim was to evaluate the effectiveness of metformin in reducing body mass index (BMI) and metabolic parameters in children treated with DSRAs. Methods We report a naturalistic study of 49 children and adolescents (mean age 14.9 ± 3.7 years), with BMI >85 percentile for age, treated with DSRAs during 2018-2020 in a child psychiatry clinic. Clinical data, anthropometric measurements, and laboratory tests were compared between those who were (study group, n = 31) and were not (control group, n = 18) treated with metformin. Results The mean study duration was 9.7 ± 5.9 months. The BMI standard deviation scores (BMI-SDS) of the study group declined significantly (from 2.08 ± 0.40 to 1.81 ± 0.54, p  less then  0.001), while the BMI-SDS of the control group did not change (from 2.03 ± 0.45 to 2.04 ± 0.47, p = 0.838). In the study group, the decline in the delta BMI-SDS/month was more robust among those with good than poor adherence to metformin (-0.047 ± 0.039 vs. -0.004 ± 0.017, p = 0.003). The decrease in BMI-SDS was greater for patients treated with risperidone and clothiapine than with other DSRAs. Fasting insulin and insulin resistance index (homeostasis model assessment of insulin resistance [HOMA-IR]) declined in the study group (from 25.4 ± 13.8 to 19.9 ± 10.7, p = 0.033 and from 5.4 ± 2.7 to 4.2 ± 2.1, p = 0.028, respectively). Conclusions Metformin treatment was associated with significant decreases in BMI, fasting insulin, and HOMA-IR. The effect of metformin seems to be dependent on adherence and type of DSRAs.DSOs have been at the forefront of adopting technology that demonstrates value-add to their businesses. Hence, DSOs have been quick to identify artificial intelligence (AI) as a transformative means to support their business and clinical processes to benefit patient care. Specifically, AI can unlock clinical insights to inform practice affiliation and post-affiliation onboarding. Next, it can help support a standard of care across practices for compliance. And finally, AI technology can improve practice performance through the use of visualization tools to support dentists with patient treatment discussions and professional development of associates. This study was intended to determine the prevalence of tongue restrictions in a pediatric population and develop a screening tool for tongue-tie symptoms. Patients were screened for tongue elevation and common symptoms using a novel Tongue Restriction Questionnaire (TRQ) that assesses symptoms throughout the lifespan. In total, 314 children (47.5% male) with a mean age of 5.8 years were screened; 25.5% of children were grade 1 (could elevate the tongue >80% to the incisive papilla), 51.3% were grade 2 (50%-80%), 20.4% were grade 3 (25%-50%), and 2.9% were grade 4 (less than 25% elevation) or most restricted. Inter-rater reliability between the dentist and the hygienist's independent grades was highly significant (ᴋ = .915, P less than .001). With regard to consideration of the child's symptoms in addition to the functional grade (tongue elevation), 26.1% of parents were interested in a referral for possible treatment; 24.5% chose to wait and consider treatment in the future if symptoms worsened; 49.4vent undertreatment and overtreatment.Iron(III)-phenolate/carboxylate complexes exhibiting photoredox chemistry and photoactivated reactive oxygen species (ROS) generation at their ligand-to-metal charge-transfer (LMCT) bands have emerged as potential strategic tools for photoactivated chemotherapy. Herein, the synthesis, in-depth characterization, photochemical assays, and remarkable red light-induced photocytotoxicities in adenocarcinomic human immortalized human keratinocytes (HaCaT) and alveolar basal epithelial (A549) cells of iron(III)-phenolate/carboxylate complex of molecular formula, [Fe(L1)(L2)] (1), where L1 is bis(3,5 di-tert-butyl-2-hydroxybenzyl)glycine and L2 is 5-(1,2-dithiolan-3-yl)-N-(1,10-phenanthroline-5-yl)pentanamide, and the gold nanocomposite functionalized with complex 1 (1-AuNPs) are reported. There was a significant red shift in the UV-visible absorption band on functionalization of complex 1 to the gold nanoparticles (λmax 573 nm, 1; λmax 660 nm, 1-AuNPs), rendering the nanocomposite an ideal candidate for photochemothunctionalized gold nanocomposite (1-AuNPs) as the emerging next-generation iron-based photochemotherapeutic agent for targeted cancer treatment modality.For intracellular molecular detection, the appropriate probes should include the abilities to enter target cells noninvasively, target specific sites, and then respond to the analytes reliably. Herein, a ratiometric fluorescent DNA nanostructure (RFDN) was designed for mitochondrial adenosine triphosphate (ATP) imaging in living cells. Rapamycin in vitro The DNA nanostructure was constructed by continuous hybridization of two hairpin DNA strands (HS1-Cy3 and HS2-Cy5) under the initiation of the trigger. HS1-Cy3 and HS2-Cy5 contained split aptamer fragments of ATP and are labeled with a fluorescent donor (Cy3) and acceptor (Cy5), respectively. The RFDN integrated multiple split aptamer fragments and increased the local concentration of sensing probes. The binding of ATP to aptamer fragments on the RFDN shortened the distance between Cy3 and Cy5, resulting in obvious ratiometric signals (fluorescence resonance energy transfer). The RFDN showed good biocompatibility and can be internalized into cells in a caveolin-dependent endocytosis pathway. The co-localization imaging results indicated that the DNA nanostructure could target the mitochondria via Cy3 and Cy5. Moreover, the confocal imaging results showed that the intracellular ATP changes stimulated by drugs in living cells could be indicated by the RFDN. In this way, the RFDN is expected to be a simple, flexible, and general platform for chemo/biosensing in living cells.Triplet harvesting under ambient conditions plays a crucial role in improving the luminescence efficiency of purely organic molecular systems. This requires elegant molecular designs that can harvest triplets either via room temperature phosphorescence (RTP) or by thermally activated delayed fluorescence (TADF). In this context, here we report a donor core-substituted pyromellitic diimide (acceptor) derivative as an efficient charge-transfer molecular design from the arylene diimide family as a triplet emitter. Solution-processed thin films of carbazole-substituted CzPhPmDI display both RTP- and TADF-mediated twin emission with a long lifetime and high efficiency under ambient conditions. The present study not only sheds light on the fundamental photophysical process involved in the triplet harvesting of donor-acceptor organic systems, but also opens new avenues in exploring an arylene diimide class of molecules as potential organic light-emitting materials.