Despite intensive measures and supportive therapy, the patient developed worsening hypoxia, refractory shock, and multiorgan failure. After discussion of goals of care with her family, a decision was made to initiate hospice care. The patient died within 72 h of hospital admission. Infection with SARS-CoV-2 is a multisystemic disease that primarily affects the lungs, but also predisposes to rare thrombo-embolic phenomena such as intracardiac thrombosis.Infection with SARS-CoV-2 is a multisystemic disease that primarily affects the lungs, but also predisposes to rare thrombo-embolic phenomena such as intracardiac thrombosis.Aim  Very little is known regarding reproductive choices, pregnancy, and delivery of women with moderate to severe hemophilia. Abemaciclib manufacturer Our aim was to describe our experience with three hemophiliac women and their journey to achieve motherhood. Methods  Medical charts of women with moderate to severe hemophilia A treated at our center were evaluated. Data regarding choices of conception, pregnancy course, mode of delivery, and pregnancy outcomes were obtained. Results  Three women are presented. Whereas patient 1 chose to adopt her first child and later had twins through egg donations and a surrogate mother, patient 2 underwent spontaneous pregnancy and delivered via cesarean section. Patient 3 preferred in vitro fertilization and preimplantation genetic diagnosis to avoid hemophilia and hemophilia carriership in her offspring. Conclusion  The appropriate means to achieve parenthood for women with moderate to severe hemophilia should be individualized and requires support of a comprehensive multidisciplinary team.Aim  To determine to what extent active cancer influences the benefit-risk relationship among patients with atrial fibrillation receiving oral anticoagulants for stroke prevention. Methods  In this cohort study of all patients with atrial fibrillation in the Swedish Patient register during 2006 to 2017, 8,228 patients with active cancer and 323,394 without cancer were followed up to 1 year after initiation of oral anticoagulants. Cox regression models, adjusting for confounders and the competing risk of death, were used to assess risk of cerebrovascular and bleeding events. Results  Among patients treated with oral anticoagulants, the risk for cerebrovascular events did not differ between cancer patients and noncancer patients (subhazard ratio [sHR] 1.12, 95% confidence interval [CI] 0.98-1.29). Cancer patients had a higher risk for bleedings (sHR 1.69, CI 1.56-1.82), but not for fatal bleedings (sHR 1.17, CI 0.80-1.70). Use of nonvitamin K oral anticoagulants was associated with lower risk of both cerebrovascular events and bleedings compared with warfarin. Conclusion  Patients with atrial fibrillation and active cancer appear to have similar net cerebrovascular benefit of oral anticoagulant treatment to patients without cancer, despite an increased risk of nonfatal bleedings. Use of nonvitamin K oral anticoagulants was associated with lower risk of all studied outcomes. COVID-19 lockdown has brought a complete shutdown of physical interaction with school friends. There was a need to assess their social and sleep habits during lockdown. A survey form was developed with the help of mentors, teachers and school children and circulated by snowball sampling method. 183 responses from Indian school children of age group between 12 and 17years, from different states were received. It was found that there was a significant alteration of sleep habits in these school children during lockdown. Many school children reported that parents showed leniency in the phone habits of school children and their interaction with friends on social media remained higher during lockdown. Despite that, they were missing their friends and wanted to meet them in-person and they felt that not doing so, was causing a reduction in focus on academics and concentration and making them lose interest in general activities and even in hobbies. Sleep quality had reduced in Indian school going students during lockdown and decreased parental control on phones was observed. The deterioration in social life of the subjects needs to be addressed and taken care of by proper planning of social interaction with ensuring physical distancing and other precautions. Sleep habits should also be modified properly by spreading awareness by parents and school authorities. Such combined measures would lead to optimal performance of school going teenagers, which seems to have suffered in this lockdown.The deterioration in social life of the subjects needs to be addressed and taken care of by proper planning of social interaction with ensuring physical distancing and other precautions. Sleep habits should also be modified properly by spreading awareness by parents and school authorities. Such combined measures would lead to optimal performance of school going teenagers, which seems to have suffered in this lockdown.Abdominal ultrasonography and intestinal ultrasonography are widely used as first diagnostic tools for investigating patients with abdominal symptoms, mainly for excluding organic diseases. However, gastrointestinal ultrasound (GIUS), as a real-time diagnostic imaging method, can also provide information on motility, flow, perfusion, peristalsis, and organ filling and emptying, with high temporal and spatial resolution. Thanks to its noninvasiveness and high repeatability, GIUS can investigate functional gastrointestinal processes and functional gastrointestinal diseases (FGID) by studying their behavior over time and their response to therapy and providing insight into their pathophysiologic mechanisms. The European Federation of Societies for Ultrasound in Medicine and Biology (EFSUMB) has established a Task Force Group consisting of GIUS experts, which developed clinical recommendations and guidelines on the role of GIUS in several acute and chronic gastrointestinal diseases. This review is dedicated to the role of GIUS in assisting the diagnosis of FGID and particularly in investigating patients with symptoms of functional disorders, such as dysphagia, reflux disorders, dyspepsia, abdominal pain, bloating, and altered bowel habits. The available scientific evidence of GIUS in detecting, assessing, and investigating FGID are reported here, while highlighting sonographic findings and its usefulness in a clinical setting, defining the actual and potential role of GIUS in the management of patients, and providing information regarding future applications and research.