Fungi living inside plants affect many aspects of plant health, but little is known about how plant genotype influences the fungal endophytic microbiome. However, a deeper understanding of interactions between plant genotype and biotic and abiotic environment in shaping the plant microbiome is of significance for modern agriculture, with implications for disease management, breeding and the development of biocontrol agents. For this purpose, we analysed the fungal wheat microbiome from seed to plant to seeds and studied how different potential sources of inoculum contributed to shaping of the microbiome. We conducted a large-scale pot experiment with related wheat cultivars over one growth-season in two environments (indoors and outdoors) to disentangle the effects of host genotype, abiotic environment (temperature, humidity, precipitation) and fungi present in the seed stock, air and soil on the succession of the endophytic fungal communities in roots, flag leaves and seeds at harvest. The communities were sn.The emerging contaminants gallium (Ga) and indium (In) are extensively used in advanced industries and are considered as toxic to humans. Limited information is available on the dynamics of Ga and In in soil-upland crop systems. Therefore, this study aimed to investigate the effects of Ga and In on the growth and uptake of Ga and In by wheat plants grown in Ga- and In-contaminated soils. The wheat seedlings were planted in soils of different properties spiked with various Ga and In concentrations (50, 100, 200, and 400 mg kg-1). The plant-available Ga, In, and Al in the soils were extracted by 0.02 M CaCl2, and their concentrations in plant tissues of wheat seedlings and plant biomass were determined after harvesting. The results indicated that the Al toxicity of wheat seedlings increased with Ga and In concentrations in acidic soils. Indium phytotoxicity was found in both neutral and acidic soils. Plant analysis results indicated that the concentration of Ga and In in roots was approximately one order of magnitude higher than that in the shoots of wheat seedlings, and the capability for Ga translocation from roots to shoots was higher than for In. The results of this study suggest that the dynamics of Ga and In in soil-upland crop systems is strongly dependent on the soil properties, such as pH and Al availability. In this study, we aimed to provide bibliometric and Altmetric overviews and visualization and to evaluate the correlation between traditional bibliometric and Altmetric analyses in the field of malnutrition. Articles published in the past decade were identified by searching for the term "malnutrition" on the Web of Science indexing database and research platform. The top 50 cited articles were analyzed in terms of title, study type, topic of study, first author, publication year, citation number, keywords, organizations, average citations per year, journal H index, impact factor, and Altmetric attention score. Also, the top 50 Altmetric articles published in the past decade about malnutrition were provided on the website Altmetric.com. Among the top 50 cited articles, the most common study type, topic of study, publication year, and keyword were, respectively, original scientific paper (n=26), definition-diagnosis of malnutrition (n=17), 2010 (n=13), and malnutrition (n=18). The article titled "Maternal and child undernutrition and overweight in low-income and middle-income countries" in Lancet had the highest citation number, and the article "Impacts of COVID-19 on childhood malnutrition and nutrition-related mortality" in Lancet had the highest Altmetric score. Evaluating academic publications with an Altmeric analysis in addition to a traditional bibliometric analysis is beneficial because Altmetric attention scores can give information about what the population wants to know about malnutrition and allows us to develop appropriate policies.Evaluating academic publications with an Altmeric analysis in addition to a traditional bibliometric analysis is beneficial because Altmetric attention scores can give information about what the population wants to know about malnutrition and allows us to develop appropriate policies. Peripheral sensory neuropathy (PSN) caused by oxaliplatin-based adjuvant chemotherapy adversely affects patients' quality of life. selleck chemicals llc This study evaluated the efficacy and safety of capecitabine plus oxaliplatin (CAPOX) with intermittent oxaliplatin use compared with the standard CAPOX in adjuvant therapy for colon cancer. Patients with curative resection for stage II/III colon cancer were randomly assigned to receive either CAPOX with continuous oxaliplatin (eight cycles of CAPOX) or CAPOX with intermittent oxaliplatin (two cycles of CAPOX, four cycles of capecitabineand two cycles of CAPOX). The primary end-point was the 1-year PSN rate, and the key secondary end-point was disease-free survival (DFS). Two hundred patients were enrolled in the intent-to-treat population. After 4 patients withdrew, 196 patients were included in the safety analysis. The overall treatment completion rate was 65% for continuous vs. 89% for intermittent treatment (p<0.001). The 1-year PSN rate was 60% (95% confidence interval [CI], 50%-70%) for continuous and 16% (95% CI, 10%-25%) for intermittent treatment (p<0.001). After a median follow-up of 52 months, 40 events (20%) were observed. The 3-year DFS was 81% (95% CI, 71%-87%) for continuous and 84% (95% CI, 75%-90%) for intermittent treatment (hazard ratio [HR], 0.87; 95% CI, 0.47-1.63). Among patients with high-risk disease (T4 or N2-3), the 3-year DFS was 57% for continuous vs. 74% for intermittent treatment (HR, 0.66). CAPOX with planned intermittent oxaliplatin may be feasible as an adjuvant therapy for colon cancer and substantially reduce the duration of long-lasting PSN. UMIN000012535.UMIN000012535.Mg2+ is an essential cation controlling many biochemical reactions. Recently, Daw et al. [1] have shown that l-lactate acts as a second messenger triggering a dynamic exchange of Mg2+ between the endoplasmic reticulum and mitochondria to shape energy metabolism. This discovery changes our view on the cellular role of Mg2+.