Through nanocarriers, a wide variety of therapeutics can be administered and targeted to the cancerous site. Some examples of the utilities of nanocarriers are codelivery of drugs, gene delivery, and delivery of other biologics. Overall, the nanocarriers have promising potential in improving therapeutic efficacy of drugs used in NSCLC.Nanocarriers can improve pharmacokinetics of the drug payload by improving its delivery to the desired location and can reduce associated systemic toxicities. Through nanocarriers, a wide variety of therapeutics can be administered and targeted to the cancerous site. Some examples of the utilities of nanocarriers are codelivery of drugs, gene delivery, and delivery of other biologics. Overall, the nanocarriers have promising potential in improving therapeutic efficacy of drugs used in NSCLC.Nanostructured electrodes are among the most important candidates for high-capacity battery chemistry. However, the high surface area they possess causes serious issues. First, it would decrease the Coulombic efficiencies. Tiragolumab research buy Second, they have significant intakes of liquid electrolytes, which reduce the energy density and increase the battery cost. Third, solid-electrolyte interphase growth is accelerated, affecting the cycling stability. Therefore, the interphase chemistry regarding electrolyte contact is crucial, which was rarely studied. Here, we present a completely new strategy of limiting effective surface area by introducing an "electrolyte-phobic surface". Using this method, the electrolyte intake was limited. The initial Coulombic efficiencies were increased up to ∼88%, compared to ∼60% of the control. The electrolyte-phobic layer of Si particles is also compatible with the binder, stabilizing the electrode for long-term cycling. This study advances the understanding of interphase chemistry, and the introduction of the universal concept of electrolyte-phobicity benefits the next-generation battery designs.Graphitic carbon nitride (g-C3N4) and its doped analogues have been studied over the past decade in part due to their promising applications in heterogeneous photocatalysis; however, the effect of doping on the photoconductivity is poorly understood. Herein, we investigate Cu doped g-C3N4 (Cu-g-C3N4) and demonstrate via extended X-ray absorption fine structure that Cu+ incorporates as an individual ion. Time-resolved optical pump terahertz probe spectroscopy was utilized to measure the ultrafast photoconductivity in response to a 400 nm pump pulse and showed that the Cu+ dopant significantly enhances photoconductivity of the as-prepared powdered sample, which decays within 10 ps. Furthermore, a film preparation technique was applied that further enhanced the photoconductivity and induced a longer-lived photoconductive state with a lifetime on the order of 100 ps. This study provides valuable insight into the ultrafast photoconductivity dynamics of g-C3N4 materials, which is essential toward developing efficient g-C3N4 photocatalysts.The intermolecular reductive radical coupling of aldehydes with nonactivated alkenes, employing metal hydride atom transfer (MHAT) catalysis with a combination of FeII and FeIII salts, is described. This constitutes the first use of aldehydes as viable acceptor groups in MHAT reactions. The insights gained in this study led to the reexamination of the previously reported intramolecular version of the reaction, and the addition of FeII salts allowed the development of a more efficient second-generation approach.Deltahedral nine-atom tetrel element Zintl clusters are promising building blocks for the straightforward solution-based synthesis of intermetalloid clusters through the reaction with organometallic compounds. Herein we report on novel coordination sites of metal-N-heterocyclic carbene (NHC) complexes to [Ge9] clusters and unexpected cluster isomerization. We present the synthesis of a series of coinage metal-NHC complexes of silylated [Ge9] clusters [NHCiPrCu(η4-Ge9Si(TMS)33)] (1; TMS = trimethylsilyl) and [NHCRM(η4-Ge9Si(TMS)32)]- (2a, M = Cu, R = iPr; 3a, M = Cu, R = Mes; 4a, M = Cu, R = Dipp; 5a, M = Ag, R = Dipp; 6a, M = Au, R = Dipp), in which the coinage metals coordinate to open rectangular cluster faces and act as additional cluster vertex atoms. Besides representing promising intermediates on the way to larger intermetalloid clusters, the formation of compound 1 shows that Cu-NHC fragments also coordinate to the open-square Ge faces of the tris-silylated [Ge9] clusters, contrasting the typical interactions with triangular faces of tris-silylated [Ge9] clusters. In compounds 3a and 4a bearing bulky NHC moieties, an unusual silyl group substitution pattern is observed in contrast to 2a, which corresponds to the silyl group arrangement of other metal complexes of bis-silylated [Ge9] clusters. In this context, potential silyl group migration mechanisms are discussed.Macrocycles and cyclic peptides are increasingly attractive therapeutic modalities as they often have improved affinity, are able to bind to extended protein surfaces, and otherwise have favorable properties. Macrocyclization of a known binder may stabilize its bioactive conformation and improve its metabolic stability, cell permeability, and in certain cases oral bioavailability. Herein, we present implementation and application of an approach that automatically generates, evaluates, and proposes cyclizations utilizing a library of well-established chemical reactions and reagents. Using the three-dimensional (3D) conformation of the linear molecule in complex with a target protein as the starting point, this approach identifies attachment points, generates linkers, evaluates their geometric compatibility, and ranks the resulting molecules with respect to their predicted conformational stability and interactions with the target protein. As we show here with prospective and retrospective case studies, this procedure can be applied for the macrocyclization of small molecules and peptides and even PROteolysis TArgeting Chimeras (PROTACs) and proteins.Genome engineering of microorganisms has become a standard in microbial biotechnologies. Several efficient tools are available for the genetic manipulation of model bacteria such as Escherichia coli and Bacillus subtilis, or the yeast Saccharomyces cerevisiae. Difficulties arise when transferring these tools to nonmodel organisms. Synthetic biology strategies relying on genome transplantation (GT) aim at using yeast cells for engineering bacterial genomes cloned as artificial chromosomes. However, these strategies remain unsuccessful for many bacteria, including Mycoplasma pneumoniae (MPN), a human pathogen infecting the respiratory tract that has been extensively studied as a model for systems biology of simple unicellular organisms. Here, we have designed a novel strategy for genome engineering based on the recombinase-assisted genomic engineering (RAGE) technology for editing the MPN genome. Using this strategy, we have introduced a 15 kbp fragment at a specific locus of the MPN genome and replaced 38 kbp from its genome by engineered versions modified either in yeast or in E.