09 - 1.34). Low performers derived a greater benefit from feedback (RR, 1.62; 95% CI, 1.18 - 2.23) compared with moderate performers (RR, 1.19; 95% CI, 1.11 - 1.29), whereas high performers did not derive a significant benefit (RR, 1.06; 95% CI, 0.99 - 1.13). Feedback was not associated with increases in withdrawal time (WMD +0.43 minutes; 95% CI, -0.50 to +1.36 minutes) or improvements in cecal intubation rate (RR, 1.00; 95% CI, 0.99 - 1.01). CONCLUSION Endoscopist feedback is associated with modest improvements in ADR. The implementation of routine endoscopist audit and feedback should be considered alongside other quality improvement interventions in institutions dedicated to the provision of high-quality screening-related colonoscopy. BACKGROUND AND AIMS Acute lower gastrointestinal bleeding (LGIB) is a common indication for hospitalization potentially requiring urgent intervention, which may not be readily available on weekends and off-hours. The aim of this study is to examine the association among weekend admission for LGIB and mortality, time to colonoscopy, length of stay, and hospital charges. METHODS The 2016 U.S. National Inpatient Sample (NIS) dataset was queried for admissions with a primary diagnosis of LGIB. Outcomes for weekend versus weekday admissions were compared using survey-adjusted Chi-square or bivariate correlation. Multivariable regression was then used to compare primary outcomes adjusting for the Elixhauser mortality score (a validated measure of comorbidities), colonoscopy, transfusion, shock, and hospital type. RESULTS An estimated 124,620 patients were admitted for LGIB in 2016. When comparing weekend with weekday admissions, there was no difference in unadjusted mortality (0.9% vs 1.0%, p=0.636). Colonoscopy within the first day (28.6% vs 23.0%, p less then 0.001) and transfusion (34.0% vs 31.5%, p less then 0.001) were more common with weekday admissions; no differences in colonoscopy rate (60.7% vs 60.9%, p=0.818), angiography rate (2.7% vs 2.7%, p=0.976), mean days to colonoscopy (2.0 vs 2.0, p=0.233), or length of stay (4.2 vs 4.1 days, p=0.068) were seen. There was no difference in multivariable adjusted mortality rates (OR, 1.11; 95% CI, 0.81-1.54; p=0.495) based on the above factors. CONCLUSIONS Early colonoscopy (within the first day) is more common for weekday admissions, but overall outcomes are not affected by weekend admission for LGIB as compared with weekday admissions. The controlled release of a drug considers the key feature of the delivery carrier that enhances therapeutic efficacy. This study was aimed at design, synthesis of nano valve and capping systems onto caged functionalized mesoporous silica nanoparticles (SBA15) with nanoflowers polylactic acid (PLA-NF). Levofloxacin (LVX) as a specific model drug was encapsulated onto series; SBA15, SBA15@NH2, and SBA15@NH2/PLA. The examined nanocarriers released in a controlled fashion by external stimuli. The delivery vehicle based on PLA-NF coated SBA15@NH2, potent conjugated with LVX with experienced a high extent of trapping content with fast releasing by pH regulating mechanism. In vial LVX released profile and in vitro antifungal forceful of the selected microbes were detected. However, SBA15@NH2/PLA exhibited pore size, surface area and pore volume 5.4 nm, 163 and 0.011 respectively, but the significantly clear zone was obtained with Staphylococcus aureus ATCC 6538 (G+ve), Escherichia coli ATCC 25922 (G-ve), Candida albicans ATCC 10231 (yeast) and Aspergillus niger NRRL A-326 (fungus). Viability test avouch that rising functionality enhanced cytocompatibility and non-toxicity profile. Based on the aforementioned promising data, this type of nanocarriers offers when functionalized with targeting cells, the accessibility to deliver antibiotics onto nanosystem for increased potency against microbes and reduce side effects. Calcitriol Cellulose derivatives have got growing interest due to their relative abundance and ability to sustain the release of medicaments. In this study, micro- and nano-fibrillated cellulose were prepared from rice straw and used as drug carriers. Both carriers in addition to another one which is nano silicon dioxide were characterized with various techniques. Methotrexate was chosen to be loaded on nano-fibrillated cellulose and nano silicon dioxide. Both methotrexate carriers were evaluated for their possible protective role against renal fibrosis induced by methotrexate in leukemia rat model. Results of this study exhibited that loading methotrexate on either nano-fibrillated cellulose or nano silicon dioxide seems to have an ameliorative role on renal function tests, inflammatory and fibrotic markers of renal tissues. Moreover, the sustained release of methotrexate for long time period maintained by nano-fibrillated cellulose carrier gives it more priority than nano silicon dioxide to be used as an effective novel drug carrier in further medical applications with minimal side effects on kidney tissue in leukemia model. Sodium alginate (SA) is a natural biopolymer that is used as biodegradable and non-toxic material in medical and pharmaceutical fields. Although crosslinked SA with calcium ions in the presence of monovalent salts are unstable. The aim of this work is to employe plant mucilage in combination of SA beads to improve the properties of SA beads. SA beads containing metformin drug (MET) were modified using basil seed mucilage (BSM) to achieve controlled release was investigated. The presence of BSM in the SA structure results in more stability, less swelling, and consequently lower release. The effect of pH 1.2 and pH 7.4 on its release and swelling of the beads was studied, and the results showed that the lowest swelling and release was from the acidic environment. Sodium Tripolyphosphate (TPP) as a cross-linker in the bead structure caused a lower release and swelling. The chemical structure of beads was confirmed by FTIR, SEM indicated the porous structure of SA bead and continuous structure of SA/BSM bead and DSC indicated that the presence of BSM in the bead structure decreased the chain motility. Also, cytotoxicity of BSM was investigated by MTT method, and the mucilage toxicity was not confirmed until 3 ml. V.