The surgical treatment of CNS actinomycetoma presented poor prognosis and a disseminating recurrence. We believe that clinicians and surgeons must be informed about these "new" infectious pathologies that are so difficult to treat, especially with the arrival of migrant patients from endemic countries in conflict. The jugular foramen (JF) can be the site of several tumours. Paragangliomas, schwannomas and meningiomas are the most commonly reported. We describe a case of melanocytoma originating from the JF and presenting with an accessory nerve palsy. Illustrative case A 48-year-old woman presented with a 6-month history of cervical and left shoulder pain with wasting and weakness of the left trapezius. A Magnetic Resonance Imaging (MRI) showed a T1-hyperintense, T2-isointense, heterogeneously enhancing lesion involving the left JF and extending into the cerebello-medullary and cerebello-pontine cisterns. A retrosigmoid craniotomy was performed and a near total removal achieved. The accessory nerve was involved by tumour and could not be preserved. Given the diagnostic uncertainty between melanotic schwannoma, metastatic melanoma and meningeal melanocytoma, next generation sequencing and genome-wide DNA methylation arrays were performed, documenting a mutation in GNA11 (c.6226A>T, p. Gln209Leu) and a methylation profile consistent with melanocytoma. The patient underwent adjuvant fractionated radiotherapy of the tumour remnant. A follow-up MRI 4 years after surgery did not show any tumour recurrence. The differential diagnosis of skull base pigmented tumours can be challenging, particularly when they occur in unusual locations such as the JF. They can be misdiagnosed given their similar clinical, neuroradiological and pathological features if anatomy of the site of origin is not carefully considered and molecular tests are not performed, leading to erroneous treatment and follow up planning.The differential diagnosis of skull base pigmented tumours can be challenging, particularly when they occur in unusual locations such as the JF. They can be misdiagnosed given their similar clinical, neuroradiological and pathological features if anatomy of the site of origin is not carefully considered and molecular tests are not performed, leading to erroneous treatment and follow up planning.Environmental contamination by microplastics (MPs) is an emerging concern in recent years due to associated adverse impacts of MPs on potential human health problems. Endothelial dysfunction is a condition in which the endothelial layer fails to form normally, and is associated with impaired vascular function. Despite the fact that MPs are known to enter the circulation system through intestinal epithelium, little has been known whether MPs impact the normal function of endothelial cells and the formation of vasculature. In the current study, we investigated the effect of polystyrene microplastics (PS-MPs) on tube formation and cytotoxicity in human umbilical vein endothelial cells (HUVECs). Our study showed that the treatment of HUVECs with PS-MPs significantly decreased cell viability, with intracellular accumulation occurring in a dose- and size-dependent manner. Moreover, significant dose-dependent inhibition of angiogenic tube formation was observed in HUVECs treated with 0.5 μm PS-MPs; this effect was accompanied by suppression of angiogenic signaling pathways and inhibitory activity against wound healing and cell migration. Regarding the mechanism of decreased viability, we observed increased autophagic and necrotic cell death. These results indicate that 6-h exposure of endothelial cells to PS-MPs represses tube-forming capacity, while 48-h exposure leads to autophagy and necrosis-mediated cytotoxicity.Effectiveness of various emotion regulation (ER) strategies have received much attention in recent research. Among the most studied ER strategies are cognitive reappraisal and expressive suppression. However, the evidence of their effectiveness is controversial and depends on the measures used. The aim of the present study was to compare the effectiveness of cognitive reappraisal and expressive suppression strategies of ER via different measures such as self-report, facial expressions (zygomaticus major and corrugator supercilii electromyography), and physiological assessment (skin conductance response and heart rate deceleration). Participants were presented with intensely unpleasant or neutral pictures and performed ER tasks. mTOR inhibitor We expected that the implementation of ER strategies would reduce negative emotions, and cognitive reappraisal would produce greater reduction in negative emotions compared to expressive suppression. Self-report data showed that reappraisal had a greater effect on the reduction of negative emotions compared to suppression. There was no difference between reappraisal and suppression assessed with skin conductance response and electromyography. Curiously, heart rate deceleration increased while participants tried to suppress their emotional expressions, which could reflect efforts exerted in the attempt to suppress. The ER strategies reduced negative emotions during the presentation of unpleasant pictures partially in skin conductance response and heart rate deceleration. Overall, reappraisal is more effective in changing subjective experience, whereas the physiological reactions do not differ substantially between the two ER strategies explored. We therefore recommend that the assessment of ER strategies in the laboratory should accommodate more than one type of measures to come to more reliable conclusions.Worldwide, potato (Solanum tuberosum L.) is the third most important food crop after rice and wheat. Its production is however constrained by several virus diseases. The occurrence and distribution of the economically important viruses and associated insect vectors is however not known for Rwanda and Burundi, where potato is an important food security and income crop. We surveyed 194 potato fields for viruses and insect vectors. Aphids were commonly found infesting farmers' potato fields in contrast to whiteflies. Testing by Enzyme Linked Immunosorbent Assay (ELISA) for six potato viruses identified five viruses potato leafroll virus (PLRV), potato virus X, S, M and Y (PVX, PVS, PVM, PVY) in Rwanda and two viruses (PLRV and PVS) in Burundi. A subset of samples were analyzed using small RNA sequencing and assembly (sRSA) and additionally revealed presence of PVX and for the first time, tobacco rattle virus (TRV) in Burundi. PLRV and PVS were most common while PVY was rare and not found in Burundi, which is highly unusual.