They reached the most critical level in children with diabetes mellitus lasting longer than 5 years. Conclusions The course of chronic catarrhal gingivitis in children, both somatically healthy and those suffering from diabetes mellitus, is associated with increased parameters of lipid peroxide oxidation and decreased enzymatic activity of the antioxidant protection system of the oral fluid. The most considerable changes are found in patients suffering from diabetes mellitus lasting more than 5 years.Conclusions The course of chronic catarrhal gingivitis in children, both somatically healthy and those suffering from diabetes mellitus, is associated with increased parameters of lipid peroxide oxidation and decreased enzymatic activity of the antioxidant protection system of the oral fluid. The most considerable changes are found in patients suffering from diabetes mellitus lasting more than 5 years. The aim was to improve the course of purulent wounds in diabetes by using physical therapies. Materials and methods we investigated 122 patients with diabetes mellitus and wound processes. We divided all patients on the two groups. Our study groups were 50 patients who had therapy by ozone together with other general treatment and surgery treatment (daily dressings, ointments and solutions). Our control groups were 72 patients, who had treated only by general methods and surgery treatment (daily dressings, ointments and solutions).The patients of our explore group had received intravenous injection of saline ozone solution together with other general treatment and surgery treatment (daily dressings, ointments and solutions). Results it had studied of indicators of oxidative modification of proteins, lipid peroxidation in blood plasma, antioxidant protection during this period, there were no significant changes in these parameters between the control and experimental groups. As the result of the study wawith complicated forms of diabetes does not cause a negative impact on the dynamics of homeostasis and indicators of the level of intoxication of the body. Ozone therapy has a beneficial effect on the course and wound process in patients with diabetes with purulent processes. The aim Study of the relationship between cervical insufficiency and dysplastic stigma in miscarriages. Materials and methods 80 pregnant women were examined at 23-27 weeks of gestation.) Group I included 40 pregnant women with the threat of premature birth, with habitual miscarriage and correction of cervical insufficiency (CI) by using pessary in the anamnesis. Group II consisted of 20 pregnant women with the threat of premature birth and correction of CI by using pessary without the burden of habitual miscarriage, the control group of 20 almost healthy pregnant women. Results The studies revealed phenotypic signs of dysplastic stigmatization in 39 (97.5 + 2.5%) pregnant women of group I, in 18 (90.0 + 6.9%) group II and in 4 (20.0 + 9.2%) control, which indicates a high prevalence of connective tissue dysplasia in women with CI, which also has a laboratory reflection in the form of increased excretion per day of oxyproline and a decrease in total glycosaminoglycans in both groups at risk of preterm birth. Conclusions The most common gestational complication in women with connective tissue dysplasia is the risk of premature birth. Improving existing and finding new diagnostic and therapeutic measures for women with UDСTD will reduce the risk of preterm birth.Conclusions The most common gestational complication in women with connective tissue dysplasia is the risk of premature birth. Improving existing and finding new diagnostic and therapeutic measures for women with UDСTD will reduce the risk of preterm birth. The aim Is to study the level of knowledge, skills, abilities, and health indicators of students during the formation of their healthy lifestyle. Materials and methods The research was conducted at Zhytomyr Ivan Franko State University and Polissya National University in 2018-2020. Thus, 882 students (385 males and 497 females) of different specialties between the ages of 17 and 23 were examined. To assess the level of knowledge, skills, and abilities of students during the formation of a healthy lifestyle, a survey was conducted. The health level of students was assessed by the method of the qualitative express assessment of the physical health level, which made it possible to assess the dynamics of the quality of forming a healthy lifestyle. Results It was found that only 5.7 % of male and 6.4 % of female students had a high level of knowledge of all the health components; only 7.0 % of male and 8.3 % of female students had a high level of knowledge about the factors of health formation and skills in higher education institutions.Conclusions The research showed that most students (both males and females) did not follow a healthy lifestyle. It was reflected in the low health level of most students and the negative dynamics of the indices that characterize the level of health in the process of studying. All this requires taking into account the features of forming a healthy lifestyle of students in physical education classes at higher education institutions. The aim Was to investigate the status of endotoxicosis parameters in patients with chronic pancreatitis depending on the presence of a combination with type 2 diabetes mellitus, as well as their impact on the functional capacity of the pancreas. Materials and methods 87 outpatients with CP with concomitant type 2 diabetes and without it were examined. The main group consisted of 62 patients with CP in the phase of therapeutic exacerbation in combination with diabetes mellitus in a state of sub- or full compensation, the comparison group - 25 patients with isolated CP, the control group consisted of 30 healthy individuals. selleck products The content of malonic aldehyde in the blood was determined by reaction with thiobarbituric acid, the levels of medium-molecular peptides MMP1 and MMP2 - by the method of Gabrielyan, circulating immune complexes - by precipitation in 3.75% ethylene glycol with followed photometry. Results The presence of active endotoxicosis and lipid peroxidation in CP was established, which was significantly more significant in the comorbidity of CP with type 2 diabetes erythrocyte intoxication index was higher by 19.