It is associated with a reduced incidence of postoperative nausea and vomiting and a higher patient satisfaction. It has no effect on urinary retention, intraoperative bradycardia, or hypotension. SA should be considered as a viable and efficient anesthetic technique in vertebral lumbar surgery.This work is concerned with the characteristics of very low frequency sound propagation (VLF, ≤100 Hz) in the shallow marine environment. Under these conditions, the classical hypothesis of considering the sea bottom as a fluid environment is no longer appropriate, and the sound propagation characteristics at the sea bottom should be also considered. Hence, based on the finite element method (FEM), and setting the sea bottom as an elastic medium, a proposed model which unifies the sea water and sea bottom is established, and the propagation characteristics in full waveguides of shallow water can be synchronously discussed. Using this model, the effects of the sea bottom topography and the various geoacoustic parameters on VLF sound propagation and its corresponding mechanisms are investigated through numerical examples and acoustic theory. The simulation results demonstrate the adaptability of the proposed model to complex shallow water waveguides and the accuracy of the calculated acoustic field. For the sea bottom topography, the greater the inclination angle of an up-sloping sea bottom, the stronger the leak of acoustic energy to the sea bottom, and the more rapid the attenuation of the acoustic energy in sea water. The effect of a down-sloping sea bottom on acoustic energy is the opposite. Moreover, the greater the pressure wave (P-wave) speed in the sea bottom, the more acoustic energy remains in the water rather than leaking into the bottom; the influence laws of the density and the shear wave (S-wave) speed in the sea bottom are opposite.The effect of TiO2 and the MgO/Al2O3 ratio on the viscosity, heat capacity, and enthalpy change of CaO-SiO2-Al2O3-MgO-TiO2 slag at constant heat input was studied. The variation of slag structure was analyzed by the calculation of activation energy and FTIR spectrum measurements. The results showed that the heat capacity and enthalpy change of the slag decreased with the increase of TiO2 content. Under constant heat supply, the fluctuations in slag temperature were relatively apparent, and the temperature of slag increased as the TiO2 content increased. The viscosity of slag decreased due to the increase in slag temperature. Increasing the MgO/Al2O3 ratio could decrease the temperature and viscosity of slag. The effect of increasing the MgO/Al2O3 ratio on the viscosity was more pronounced than the decreasing temperature caused by increasing the MgO/Al2O3 ratio. The apparent activation energy decreased with increasing TiO2 content and MgO/Al2O3 ratio. read more The Ti-O bonds formed with TiO2 addition, and the Ti-O bonds were weaker than Si-O bonds, which resulted in the decrease in heat capacity and viscosity of slag. The imputation of missingness is a key step in Electronic Health Records (EHR) mining, as it can significantly affect the conclusions derived from the downstream analysis in translational medicine. The missingness of laboratory values in EHR is not at random, yet imputation techniques tend to disregard this key distinction. Consequently, the development of an adaptive imputation strategy designed specifically for EHR is an important step in improving the data imbalance and enhancing the predictive power of modeling tools for healthcare applications. We analyzed the laboratory measures derived from Geisinger's EHR on patients in three distinct cohorts-patients tested for (Cdiff) infection, patients with a diagnosis of inflammatory bowel disease (IBD), and patients with a diagnosis of hip or knee osteoarthritis (OA). We extracted Logical Observation Identifiers Names and Codes (LOINC) from which we excluded those with 75% or more missingness. The comorbidities, primary or secondary diagnosis, as well as taset was recorded as -35.5 for the Cdiff, -8.3 for the IBD, and -11.3 for the OA dataset. An adaptive imputation strategy designed specifically for EHR that uses complementary information from the clinical profile of the patient can be used to improve the imputation of missing laboratory values, especially when laboratory codes with high levels of missingness are included in the analysis.An adaptive imputation strategy designed specifically for EHR that uses complementary information from the clinical profile of the patient can be used to improve the imputation of missing laboratory values, especially when laboratory codes with high levels of missingness are included in the analysis.Calmodulin (CaM) is an important intracellular protein that binds Ca2+ and functions as a critical second messenger involved in numerous biological activities through extensive interactions with proteins and peptides. CaM's ability to adapt to binding targets with different structures is related to the flexible central helix separating the N- and C-terminal lobes, which allows for conformational changes between extended and collapsed forms of the protein. CaM-binding targets are most often identified using prediction algorithms that utilize sequence and structural data to predict regions of peptides and proteins that can interact with CaM. In this review, we provide an overview of different CaM-binding proteins, the motifs through which they interact with CaM, and shared properties that make them good binding partners for CaM. Additionally, we discuss the historical and current methods for predicting CaM binding, and the similarities and differences between these methods and their relative success at prediction. As new CaM-binding proteins are identified and classified, we will gain a broader understanding of the biological processes regulated through changes in Ca2+ concentration through interactions with CaM.Exosomes are lipid bilayer particles released from cells into their surrounding environment. These vesicles are mediators of near and long-distance intercellular communication and affect various aspects of cell biology. In addition to their biological function, they play an increasingly important role both in diagnosis and as therapeutic agents. In this paper, we review recent literature related to the molecular composition of exosomes, paying special attention to their role in pathogenesis, along with their application as biomarkers and as therapeutic tools. In this context, we analyze the potential use of exosomes in biomedicine, as well as the limitations that preclude their wider application.